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Cars Gene Detail
Summary
  • Symbol
    Cars
  • Name
    cysteinyl-tRNA synthetase
  • Synonyms
    CA3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351477
    NCBI Gene: 27267
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:143557230-143600090 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 88.25 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    383 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351477
protein coding gene Chr7:143557230-143600090 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033276
protein coding gene Chr7:148860991-148905258 (-)
A/J MGP_AJ_G0033259
protein coding gene Chr7:144539462-144582515 (-)
AKR/J MGP_AKRJ_G0033190
protein coding gene Chr7:148597352-148640617 (-)
BALB/cJ MGP_BALBcJ_G0033259
protein coding gene Chr7:144325642-144369050 (-)
C3H/HeJ MGP_C3HHeJ_G0032975
protein coding gene Chr7:148354579-148400471 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033769
protein coding gene Chr7:154229668-154274308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030742
protein coding gene Chr7:145759614-145801278 (-)
CAST/EiJ MGP_CASTEiJ_G0032297
protein coding gene Chr7:140673618-140721269 (-)
CBA/J MGP_CBAJ_G0032946
protein coding gene Chr7:159490495-159542005 (-)
DBA/2J MGP_DBA2J_G0033100
protein coding gene Chr7:142513572-142556538 (-)
FVB/NJ MGP_FVBNJ_G0033048
protein coding gene Chr7:142448338-142497414 (-)
LP/J MGP_LPJ_G0033192
protein coding gene Chr7:150377488-150420361 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033082
protein coding gene Chr7:160081033-160126482 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033789
protein coding gene Chr7:147569655-147615364 (-)
PWK/PhJ MGP_PWKPhJ_G0032006
protein coding gene Chr7:135827779-135871190 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031852
protein coding gene Chr7:134383205-134426046 (-)
WSB/EiJ MGP_WSBEiJ_G0032409
protein coding gene Chr7:148565158-148612370 (-)



Homology
more
  • Human Ortholog
    CARS, cysteinyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CARS, cysteinyl-tRNA synthetase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CARS1, CYSRS, MGC:11246
  • Links
    NCBI Gene ID: 833
    neXtProt AC: NX_P49589
    UniProt: P49589

  • Chr Location
    11p15.4; chr11:3000922-3057451 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1328
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CARS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27267 NCBI Gene Model | MGI Sequence Detail 42861 C57BL/6J ±  kb
transcript NM_013742 RefSeq | MGI Sequence Detail 3236 C57BL/6  
polypeptide Q9ER72 UniProt | EBI | MGI Sequence Detail 831 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005045 cysteine--tRNA ligase, cytoplasmic
  • EC
  • InterPro Domains
    IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
    IPR015803 Cysteine-tRNA ligase
    IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR032678 tRNA synthetases class I, catalytic domain
Molecular
Reagents
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  • All nucleic 89
    Genomic 1
    cDNA 87
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:49497 Sowden J, et al., Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. Gene. 1998 Jul 3;214(1-2):157-65
  • Latest
    J:240003 Laguesse S, et al., A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Dev Cell. 2015 Dec 07;35(5):553-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory