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Cars Gene Detail
Summary
  • Symbol
    Cars
  • Name
    cysteinyl-tRNA synthetase
  • Synonyms
    CA3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351477
    NCBI Gene: 27267
Location & Maps
more
  • Sequence Map
    Chr7:143557230-143600090 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42861 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CARS, cysteinyl-tRNA synthetase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CARS, cysteinyl-tRNA synthetase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CARS1, CYSRS, MGC:11246
  • Links
    NCBI Gene ID: 833
    neXtProt AC: NX_P49589

  • Chr Location
    11p15.5; chr11:3000922-3057451 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1328
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CARS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    41
  • Gene trapped
    38
  • Targeted
    3
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024014 VEGA Gene Model | MGI Sequence Detail 42861 C57BL/6J ±  kb
transcript OTTMUST00000058707 VEGA | MGI Sequence Detail 3222 Not Applicable  
polypeptide OTTMUSP00000028486 VEGA | MGI Sequence Detail 831 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    383 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000005045 cysteine--tRNA ligase, cytoplasmic
  • EC
  • InterPro Domains
    IPR009080 Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
    IPR015803 Cysteine-tRNA ligase
    IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
    IPR032678 tRNA synthetases class I, catalytic domain
Molecular
Reagents
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  • All nucleic 88
    Genomic 1
    cDNA 86
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:49497 Sowden J, et al., Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. Gene. 1998 Jul 3;214(1-2):157-65
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory