Cars
Gene Detail

Symbol Name ID

Cars cysteinyl-tRNA synthetase MGI:1351477

Synonyms

CA3

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr7:143557230-143600090 bp, - strand From VEGA annotation of GRCm38   42861 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1328  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cars

Human homologs

Human Homolog		CARS, cysteinyl-tRNA synthetase
NCBI Gene ID		833
neXtProt AC		NX_P49589
Human Synonyms		CARS1, CYSRS, MGC:11246
Human Chr (Location)		11p15.5; chr11:3022152-3078681 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(41) : Targeted(3) Gene trapped(38)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cysteinyl-tRNA aminoacylation, translation, ...
Component	cytoplasm, cytosol
Function	aminoacyl-tRNA ligase activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (21)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(89) Genomic(1) cDNA(87) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024014 (Evidence)
Ensembl Gene Model	ENSMUSG00000010755 (Evidence)
Entrez Gene	27267 (Evidence)
UniGene	125659
DFCI	TC1574402
DoTS	DT.101737440, DT.494158
NIA Mouse Gene Index	U029512
EC	6.1.1.16
Consensus CDS Project	CCDS40198.1, CCDS57597.1
International Mouse Knockout Project Status	Cars

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024014	VEGA Gene Model | MGI Sequence Detail	42861	C57BL/6J
transcript	OTTMUST00000058707	VEGA | MGI Sequence Detail	3222	Not Applicable
polypeptide	OTTMUSP00000028486	VEGA | MGI Sequence Detail	831	Not Applicable

All sequences(59) RefSeq(4) UniProt(4)

Polymorphisms

PCR(1) : SNPs(164 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009080	Aminoacyl-tRNA synthetase, class 1a, anticodon-binding
InterPro	IPR015803	Cysteine-tRNA ligase
InterPro	IPR024909	Cysteinyl-tRNA synthetase/mycothiol ligase
InterPro	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology	PR:000005045	cysteinyl-tRNA synthetase, cytoplasmic

References

(Earliest) J:49497 Sowden J, et al., Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene. Gene. 1998 Jul 3;214(1-2):157-65
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)