Nufip1 MGI Mouse Gene Detail - MGI:1351474 - nuclear FMR1 interacting protein 1

Symbol

Nufip1
Name

nuclear FMR1 interacting protein 1

Feature Type

protein coding gene
IDs

MGI:1351474
NCBI Gene: 27275
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr14:76348331-76374819 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 40.35 cM, cytoband D2
Mapping Data

2 experiments

SNPs within 2kb

216 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1351474	protein coding gene	Chr14:76348307-76374819 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021579	protein coding gene	Chr14:71016670-71043525 (+)
A/J	MGP_AJ_G0021537	protein coding gene	Chr14:69378467-69404955 (+)
AKR/J	MGP_AKRJ_G0021514	protein coding gene	Chr14:71449496-71476550 (+)
BALB/cJ	MGP_BALBcJ_G0021544	protein coding gene	Chr14:69170503-69196991 (+)
C3H/HeJ	MGP_C3HHeJ_G0021321	protein coding gene	Chr14:71170353-71197501 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021984	protein coding gene	Chr14:74112886-74139374 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019522	protein coding gene	Chr14:66989677-67018244 (+)
CAST/EiJ	MGP_CASTEiJ_G0020838	protein coding gene	Chr14:67864541-67892340 (+)
CBA/J	MGP_CBAJ_G0021289	protein coding gene	Chr14:76493563-76521391 (+)
DBA/2J	MGP_DBA2J_G0021412	protein coding gene	Chr14:68782217-68808690 (+)
FVB/NJ	MGP_FVBNJ_G0021390	protein coding gene	Chr14:68123720-68150203 (+)
LP/J	MGP_LPJ_G0021482	protein coding gene	Chr14:72158907-72185445 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021417	protein coding gene	Chr14:75194942-75221408 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022007	protein coding gene	Chr14:70731127-70757545 (+)
PWK/PhJ	MGP_PWKPhJ_G0020581	protein coding gene	Chr14:65527706-65554500 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020418	protein coding gene	Chr14:66687108-66714782 (+)
WSB/EiJ	MGP_WSBEiJ_G0020891	protein coding gene	Chr14:71066615-71093100 (+)

Human Ortholog

NUFIP1, nuclear FMR1 interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUFIP1, nuclear FMR1 interacting protein 1
Synonyms

bA540M5.1, NUFIP, Rsa1
Links

HGNC:8057

NCBI Gene ID: 26747

neXtProt AC: NX_Q9UHK0

UniProt: Q9UHK0
Chr Location

13q14.12; chr13:44939249-44989471 (-) GRCh38

MGI Vertebrate Homology

Nufip1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUFIP1
Gene Tree

Nufip1

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

3
Targeted

2
Genomic Mutations

1 involving Nufip1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a conditional allele activated in fibroblasts exhibit reduced proliferation of implanted tumor cells.

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All GO Annotations

35
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

9
cDNA Data

60
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nufip1

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All Sequences

40
RefSeq

8
UniProt

1
CCDS

CCDS27284.1

Ensembl

ENSMUSG00000022009 (Evidence)
NCBI Gene

27275

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022009	Ensembl Gene Model \| MGI Sequence Detail	26489	C57BL/6J	± kb
transcript	ENSMUST00000022586	Ensembl \| MGI Sequence Detail	3974	Not Applicable
polypeptide	ENSMUSP00000022586	Ensembl \| MGI Sequence Detail	484	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011501 FMR1-interacting protein NUFIP1

(term hierarchy)
InterPro Domains

IPR019496 FMR1-interacting protein 1, conserved domain

IPR013087 Zinc finger C2H2-type

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All nucleic 61

cDNA 60

Primer pair 1

Microarray probesets 4

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 11
Earliest

J:58813 Bardoni B, et al., A novel RNA-binding nuclear protein that interacts with the fragile X mental retardation (FMR1) protein. Hum Mol Genet. 1999 Dec;8(13):2557-66
Latest

J:330821 Yuan M, et al., Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth. Nat Cancer. 2022 Aug;3(8):945-960

TSS for Nufip1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126702	Chr14:76348325-76348368 (+)	16 bp
Tssr126703	Chr14:76352253-76352300 (+)	3,946 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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