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Plekhb1 Gene Detail
Summary
  • Symbol
    Plekhb1
  • Name
    pleckstrin homology domain containing, family B (evectins) member 1
  • Synonyms
    evt-1, PHR1, Phret1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351469
    NCBI Gene: 27276
Location & Maps
more
  • Sequence Map
    Chr7:100642892-100662414 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19523 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PLEKHB1, pleckstrin homology domain containing B1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PLEKHB1, pleckstrin homology domain containing B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KPL1, PHR1, PHRET1
  • Links
    NCBI Gene ID: 58473
    neXtProt AC: NX_Q9UF11

  • Chr Location
    11q13.4; chr11:73646178-73662819 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Plekhb1
  • Incidental Mutations
Homozygous null mice are viable with no abnormalities detected in growth, behavior including balance, inner ear histology, or serum and urine electrolyte concentrations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025179 VEGA Gene Model | MGI Sequence Detail 19523 C57BL/6J ±  kb
transcript OTTMUST00000061972 VEGA | MGI Sequence Detail 2079 Not Applicable  
polypeptide OTTMUSP00000030495 VEGA | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    234 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 114
    cDNA 113
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2141901
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:58784 Xu S, et al., PHR1 encodes an abundant, pleckstrin homology domain-containing integral membrane protein in the photoreceptor outer segments. J Biol Chem. 1999 Dec 10;274(50):35676-85
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory