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Plek2 Gene Detail
Summary
  • Symbol
    Plek2
  • Name
    pleckstrin 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351466
    NCBI Gene: 27260
  • Gene Overview
    MyGene.info: PLEK2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:78888691-78906964 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351466
protein coding gene Chr12:78888691-78907182 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019875
protein coding gene Chr12:79164840-79184957 (-)
A/J MGP_AJ_G0019833
protein coding gene Chr12:76315739-76333804 (-)
AKR/J MGP_AKRJ_G0019808
protein coding gene Chr12:78385907-78403814 (-)
BALB/cJ MGP_BALBcJ_G0019812
protein coding gene Chr12:76568637-76586660 (-)
C3H/HeJ MGP_C3HHeJ_G0019618
protein coding gene Chr12:78856504-78875800 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020264
protein coding gene Chr12:81506839-81526253 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017882
protein coding gene Chr12:73337912-73357177 (-)
CAST/EiJ MGP_CASTEiJ_G0019168
protein coding gene Chr12:73685042-73709006 (-)
CBA/J MGP_CBAJ_G0019588
protein coding gene Chr12:84671809-84694029 (-)
DBA/2J MGP_DBA2J_G0019704
protein coding gene Chr12:75942995-75961277 (-)
FVB/NJ MGP_FVBNJ_G0019690
protein coding gene Chr12:74753731-74772118 (-)
LP/J MGP_LPJ_G0019776
protein coding gene Chr12:79090436-79110719 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019729
protein coding gene Chr12:87729605-87747836 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020300
protein coding gene Chr12:77901643-77922359 (-)
PWK/PhJ MGP_PWKPhJ_G0018934
protein coding gene Chr12:70281589-70302493 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018728
protein coding gene Chr12:72402604-72423166 (-)
WSB/EiJ MGP_WSBEiJ_G0019221
protein coding gene Chr12:78498475-78519747 (-)



Homology
more
  • Human Ortholog
    PLEK2, pleckstrin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLEK2, pleckstrin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 26499
    neXtProt AC: NX_Q9NYT0
    UniProt: Q9NYT0

  • Chr Location
    14q23.3-q24.1; chr14:67386979-67412200 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021118 Ensembl Gene Model | MGI Sequence Detail 18274 C57BL/6J ±  kb
transcript ENSMUST00000021544 Ensembl | MGI Sequence Detail 1583 Not Applicable  
polypeptide ENSMUSP00000021544 Ensembl | MGI Sequence Detail 353 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 2
References
more
  • Summaries
    All 30
    Gene Ontology 8
    Phenotypes 5
  • Earliest
    J:58788 Inazu T, et al., Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family. Biochem Biophys Res Commun. 1999 Nov;265(1):87-93
  • Latest
    J:257910 Zhao B, et al., Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms. J Clin Invest. 2018 Jan 2;128(1):125-140

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory