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Atic
Gene Detail
Symbol

Name
ID
Atic
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
MGI:1351352
Synonyms
2610509C24Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
36.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:71557150-71579631 bp, + strand
From VEGA annotation of GRCm38

  22482 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2983  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATIC
Protein SuperFamily: bifunctional purine biosynthesis protein, PurH type
Gene Tree: Atic

Human
homologs
ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 471
neXtProt AC: NX_P31939

Human Synonyms: AICAR, AICARFT, HEL-S-70p, IMPCHASE, PURH

Human Chr (Location): 2q35; chr2:215311956-215349773 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ATIC

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Atic interacts with 123 markers (Mir7-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process 'de novo' IMP biosynthetic process, dihydrofolate metabolic process, ...
Component extracellular exosome, membrane, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (163)    Tissues (129)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 159
RT-PCR 4
cDNA source data(118)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase atic    NEW 
Molecular
reagents
All nucleic(124) cDNA(122) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000033605 (Evidence)
Ensembl Gene Model ENSMUSG00000026192 (Evidence)
Entrez Gene 108147 (Evidence)
UniGene 38010
DFCI TC1575062, TC1658819
DoTS DT.101199951, DT.40169337, DT.494050, DT.91555706
EC 2.1.2.3, 3.5.4.10
Consensus CDS Project CCDS15030.1
International Mouse Phenotyping Consortium Status Atic
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033605 VEGA Gene Model | MGI Sequence Detail 22482 C57BL/6J ±  kb
transcript OTTMUST00000084659 VEGA | MGI Sequence Detail 2845 Not Applicable 
polypeptide OTTMUSP00000045654 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002695 AICARFT/IMPCHase bienzyme
InterPro IPR024051 AICAR transformylase domain
InterPro IPR024050 AICAR transformylase, insert domain
InterPro IPR016193 Cytidine deaminase-like
InterPro IPR011607 Methylglyoxal synthase-like domain
Protein Ontology PR:000004423 bifunctional purine biosynthesis protein PURH
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)
Other
accession IDs
MGI:1914741, MGI:2138111, MGI:2138576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory