Atic
Gene Detail

Symbol Name ID

Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase MGI:1351352

Synonyms

2610509C24Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

36.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:71557150-71579631 bp, + strand From VEGA annotation of GRCm38   22482 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Atic ± 2 cM)

Protein SuperFamily: bifunctional purine biosynthesis protein, PurH type
Gene Tree: Atic

Human ortholog

ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase NCBI Gene ID 471
Human Synonyms: AICAR, AICARFT, IMPCHASE, PURH
Human Chr2:216176679-216214496 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ATIC (1)

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	'de novo' IMP biosynthetic process, dihydrofolate metabolic process, ...
Component	mitochondrion
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (163)    Tissues (129)    Images (34)
Theiler Stages: 19, 22, 23, 24, 28

Assay Type	Results
RNA in situ	159
RT-PCR	4

cDNA source data(118)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(124) cDNA(122) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000033605 (Evidence)
Ensembl Gene Model	ENSMUSG00000026192 (Evidence)
Entrez Gene	108147 (Evidence)
UniGene	38010
DFCI	TC1575062, TC1658819
DoTS	DT.101199951, DT.40169337, DT.494050, DT.91555706
EC	2.1.2.3, 3.5.4.10
Consensus CDS Project	CCDS15030.1
International Mouse Knockout Project Status	Atic

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033605	VEGA Gene Model | MGI Sequence Detail	22482	C57BL/6J
transcript	OTTMUST00000084659	VEGA | MGI Sequence Detail	2845	Not Applicable
polypeptide	OTTMUSP00000045654	VEGA | MGI Sequence Detail	592	Not Applicable

All sequences(44) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(230 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002695	AICARFT/IMPCHase bienzyme
InterPro	IPR024051	AICAR transformylase domain
InterPro	IPR024050	AICAR transformylase, insert domain
InterPro	IPR016193	Cytidine deaminase-like
InterPro	IPR011607	Methylglyoxal synthase-like domain
Protein Ontology	PR:000004423	bifunctional purine biosynthesis protein PURH

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)

Other accession IDs

MGI:1914741, MGI:2138111, MGI:2138576