Grm7
Gene Detail

Symbol Name ID

Grm7 glutamate receptor, metabotropic 7 MGI:1351344

Synonyms

6330570A01Rik, E130018M02Rik, Gpr1g, mGlu7a receptor, mGluR7

Feature Type

protein coding gene

Genetic Map

Chromosome 6

51.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:110645581-111567230 bp, + strand From VEGA annotation of GRCm38   921650 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Grm7 ± 2 cM)

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm7

Human ortholog

GRM7 glutamate receptor, metabotropic 7 NCBI Gene ID 2917
Human Synonyms: GLUR7, GPRC1G, MGLU7, MGLUR7
Human Chr3:6902802-7783218 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol.

 

Gene Ontology (GO) classifications

All GO classifications: (66 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, adult behavior, ...
Component	asymmetric synapse, axon, ...
Function	adenylate cyclase inhibiting G-protein coupled glutamate receptor activity, adenylate cyclase inhibitor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (148)    Tissues (91)    Images (57)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	24
In situ reporter (knock in)	86
RT-PCR	38

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037574 (Evidence)
Ensembl Gene Model	ENSMUSG00000056755 (Evidence)
Entrez Gene	108073 (Evidence)
UniGene	240881
DFCI	TC1584873, TC1592612, TC1596410, TC1624716
DoTS	DT.101323849, DT.55205961, DT.91348524, DT.91367740
NIA Mouse Gene Index	U007254, U065515
Consensus CDS Project	CCDS39587.1
International Mouse Knockout Project Status	Grm7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037574	VEGA Gene Model | MGI Sequence Detail	921650	C57BL/6J
transcript	OTTMUST00000096871	VEGA | MGI Sequence Detail	3127	Not Applicable
polypeptide	OTTMUSP00000054180	VEGA | MGI Sequence Detail	922	Not Applicable

All sequences(53) RefSeq(2) UniProt(10)

Polymorphisms

SNPs(5091 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017979	GPCR, family 3, conserved site
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR000162	GPCR, family 3, metabotropic glutamate receptor
InterPro	IPR001883	GPCR, family 3, metabotropic glutamate receptor 7
InterPro	IPR011500	GPCR, family 3, nine cysteines domain
Protein Ontology	PR:000008269	metabotropic glutamate receptor 7

References

(Earliest) J:39076 Kaupmann K, et al., Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors [see comments]. Nature. 1997 Mar 20;386(6622):239-46
(Latest) J:192687 Summa M, et al., Presynaptic mGlu7 receptors control GABA release in mouse hippocampus. Neuropharmacology. 2013 Mar;66:215-24
All references(54)

Other accession IDs

MGD-MRK-10270, MGI:2141737, MGI:2442018, MGI:95831