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Grm7 Gene Detail
Summary
  • Symbol
    Grm7
  • Name
    glutamate receptor, metabotropic 7
  • Synonyms
    6330570A01Rik, E130018M02Rik, Gpr1g, mGlu7a receptor, mGluR7, SMN2, Tg(SMN2)89Ahmb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351344
    NCBI Gene: 108073
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:110645581-111567230 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 51.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351344
protein coding gene Chr6:110645458-111567230 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031104
protein coding gene Chr6:113009955-113969550 (+)
A/J MGP_AJ_G0031073
protein coding gene Chr6:108718917-109638803 (+)
AKR/J MGP_AKRJ_G0031004
protein coding gene Chr6:111643019-112586236 (+)
BALB/cJ MGP_BALBcJ_G0031084
protein coding gene Chr6:108659432-109591041 (+)
C3H/HeJ MGP_C3HHeJ_G0030624
protein coding gene Chr6:71730715-72671734 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031543
protein coding gene Chr6:115988675-116987743 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028707
protein coding gene Chr6:105817032-106684752 (+)
CAST/EiJ MGP_CASTEiJ_G0030191
protein coding gene Chr6:112036905-112996874 (+)
CBA/J MGP_CBAJ_G0030770
protein coding gene Chr6:120476276-121550443 (+)
DBA/2J MGP_DBA2J_G0030923
protein coding gene Chr6:107812316-108750017 (+)
FVB/NJ MGP_FVBNJ_G0030877
protein coding gene Chr6:106831611-107730213 (+)
LP/J MGP_LPJ_G0031003
protein coding gene Chr6:113092655-114059795 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030911
protein coding gene Chr6:124850785-125922065 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031570
protein coding gene Chr6:111627195-112579969 (+)
PWK/PhJ MGP_PWKPhJ_G0029907
protein coding gene Chr6:106744259-107662132 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029735
protein coding gene Chr6:110383436-111362799 (+)
WSB/EiJ MGP_WSBEiJ_G0030275
protein coding gene Chr6:112124701-112969014 (+)



Homology
more
  • Human Ortholog
    GRM7, glutamate metabotropic receptor 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRM7, glutamate metabotropic receptor 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87
  • Links
    NCBI Gene ID: 2917
    neXtProt AC: NX_Q14831
    UniProt: Q14831

  • Chr Location
    3p26.1; chr3:6861097-7743032 (+)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 3 genetic backgrounds
    87 phenotypes from multigenic genotypes
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056755 Ensembl Gene Model | MGI Sequence Detail 921650 C57BL/6J ±  kb
transcript ENSMUST00000071076 Ensembl | MGI Sequence Detail 3127 Not Applicable  
polypeptide ENSMUSP00000064404 Ensembl | MGI Sequence Detail 922 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR000162 GPCR, family 3, metabotropic glutamate receptor
    IPR001883 GPCR, family 3, metabotropic glutamate receptor 7
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR038550 GPCR, family 3, nine cysteines domain superfamily
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10270, MGI:2141737, MGI:2442018, MGI:2676918, MGI:95831
References
more
  • Summaries
    All 171
    Developmental Gene Expression 6
    Diseases 9
    Gene Ontology 15
    Phenotypes 128
  • Earliest
    J:39076 Kaupmann K, et al., Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors [see comments]. Nature. 1997 Mar 20;386(6622):239-46
  • Latest
    J:265815 Iyer CC, et al., Mild SMN missense alleles are only functional in the presence of SMN2 in mammals. Hum Mol Genet. 2018 Oct 1;27(19):3404-3416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory