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Grm7 Gene Detail
Summary
  • Symbol
    Grm7
  • Name
    glutamate receptor, metabotropic 7
  • Synonyms
    6330570A01Rik, E130018M02Rik, Gpr1g, mGlu7a receptor, mGluR7, SMN2, Tg(SMN2)89Ahmb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351344
    NCBI Gene: 108073
Location & Maps
more
  • Sequence Map
    Chr6:110645581-111567230 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      921650 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 51.19 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GRM7, glutamate metabotropic receptor 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRM7, glutamate metabotropic receptor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87
  • Links
    NCBI Gene ID: 2917
    neXtProt AC: NX_Q14831

  • Chr Location
    3p26.1-p25.1; chr3:6861097-7741531 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    29 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 3 genetic backgrounds
    86 phenotypes from multigenic genotypes
    105 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Grm7
  • Incidental Mutations
Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037574 VEGA Gene Model | MGI Sequence Detail 921650 C57BL/6J ±  kb
transcript OTTMUST00000096871 VEGA | MGI Sequence Detail 3127 Not Applicable  
polypeptide OTTMUSP00000054180 VEGA | MGI Sequence Detail 922 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    8120 from dbSNP Build 142
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000008269 metabotropic glutamate receptor 7
  • InterPro Domains
    IPR000337 GPCR, family 3
    IPR017979 GPCR, family 3, conserved site
    IPR017978 GPCR family 3, C-terminal
    IPR000162 GPCR, family 3, metabotropic glutamate receptor
    IPR001883 GPCR, family 3, metabotropic glutamate receptor 7
    IPR011500 GPCR, family 3, nine cysteines domain
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10270, MGI:2141737, MGI:2442018, MGI:2676918, MGI:95831
References
more
  • Summaries
    All 141
    Developmental Gene Expression 4
    Diseases 29
    Gene Ontology 14
    Phenotypes 105
  • Earliest
    J:39076 Kaupmann K, et al., Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors [see comments]. Nature. 1997 Mar 20;386(6622):239-46
  • Latest
    J:231598 Zhou C, et al., Defects in Motoneuron-Astrocyte Interactions in Spinal Muscular Atrophy. J Neurosci. 2016 Feb 24;36(8):2543-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory