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Grm7
Gene Detail
 Symbol
Name
ID
Grm7
glutamate receptor, metabotropic 7
MGI:1351344
Synonyms 6330570A01Rik, E130018M02Rik, Gpr1g, mGlu7a receptor, mGluR7
Feature Type protein coding gene
Genetic Map
Chromosome 6
51.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:110645581-111567230 bp, + strand
From VEGA annotation of GRCm38

  921650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm7

Human
homologs
Human Homolog GRM7, glutamate receptor, metabotropic 7
NCBI Gene ID 2917
neXtProt AC  NX_Q14831
Human Synonyms  GLUR7, GPRC1G, MGLU7, MGLUR7
Human Chr (Location)  3p26.1-p25.1; chr3:6861115-7741531 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol.
 
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, adult behavior, ...
Component asymmetric synapse, axon, ...
Function adenylate cyclase inhibiting G-protein coupled glutamate receptor activity, adenylate cyclase inhibitor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (148)    Tissues (91)    Images (57)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 86
RT-PCR 38
cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000037574 (Evidence)
Ensembl Gene ModelENSMUSG00000056755 (Evidence)
Entrez Gene108073 (Evidence)
UniGene240881
DFCITC1584873, TC1592612, TC1596410, TC1624716
DoTSDT.101323849, DT.55205961, DT.91348524, DT.91367740
NIA Mouse Gene IndexU007254, U065515
Consensus CDS ProjectCCDS39587.1
International Mouse Knockout Project StatusGrm7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037574 VEGA Gene Model | MGI Sequence Detail 921650 C57BL/6J ±  kb
transcript OTTMUST00000096871 VEGA | MGI Sequence Detail 3127 Not Applicable 
polypeptide OTTMUSP00000054180 VEGA | MGI Sequence Detail 922 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(17) UniProt(10)
Polymorphisms SNPs within 2kb(8208 from dbSNP Build 137)    SNPs within 2kb including multiple locations(8210)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001883 GPCR, family 3, metabotropic glutamate receptor 7
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008269 metabotropic glutamate receptor 7
References (Earliest) J:39076 Kaupmann K, et al., Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors [see comments]. Nature. 1997 Mar 20;386(6622):239-46
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(56)
Other
accession IDs
MGD-MRK-10270, MGI:2141737, MGI:2442018, MGI:95831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory