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Grm7
Gene Detail
Symbol

Name
ID
Grm7
glutamate receptor, metabotropic 7
MGI:1351344
Synonyms
6330570A01Rik, E130018M02Rik, Gpr1g, mGlu7a receptor, mGluR7
Feature Type
protein coding gene
Genetic Map
Chromosome 6
51.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:110645581-111567230 bp, + strand
From VEGA annotation of GRCm38

  921650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRM7
Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm7

Human
homologs
GRM7, glutamate receptor, metabotropic 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2917
neXtProt AC: NX_Q14831

Human Synonyms: GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87

Human Chr (Location): 3p26.1-p25.1; chr3:6861097-7741531 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Spontaneous(1) Targeted(4)
Genomic Mutations involving Grm7 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol.
 
Interactions
Grm7 interacts with 431 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (3 records)
Data Summary: Results (148)    Tissues (91)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 86
RT-PCR 38
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grm7    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037574 (Evidence)
Ensembl Gene Model ENSMUSG00000056755 (Evidence)
Entrez Gene 108073 (Evidence)
UniGene 240881
DFCI TC1624716, TC1592612, TC1596410, TC1584873
DoTS DT.91367740, DT.55205961, DT.91348524, DT.101323849
NIA Mouse Gene Index U007254, U065515
Consensus CDS Project CCDS39587.1
International Mouse Phenotyping Consortium Status Grm7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037574 VEGA Gene Model | MGI Sequence Detail 921650 C57BL/6J ±  kb
transcript OTTMUST00000096871 VEGA | MGI Sequence Detail 3127 Not Applicable 
polypeptide OTTMUSP00000054180 VEGA | MGI Sequence Detail 922 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(20) UniProt(9)
Polymorphisms
SNPs within 2kb(8208 from dbSNP Build 137)    SNPs within 2kb including multiple locations(8210)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001883 GPCR, family 3, metabotropic glutamate receptor 7
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008269 metabotropic glutamate receptor 7
References
(Earliest) J:39076 Kaupmann K, et al., Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors [see comments]. Nature. 1997 Mar 20;386(6622):239-46
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(54)
Other
accession IDs
MGD-MRK-10270, MGI:2141737, MGI:2442018, MGI:95831

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory