About   Help   FAQ
Gene Detail
glutamate receptor, metabotropic 1
Synonyms 4930455H15Rik, Gprc1a, Grm1, mGluR1, nmf373, rcw
Feature Type protein coding gene
Genetic Map
Chromosome 10
3.44 cM, cytoband A2
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr10:10686059-11082356 bp, - strand
From VEGA annotation of GRCm38

  396298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm1

Human Homolog GRM1, glutamate receptor, metabotropic 1
NCBI Gene ID 2911
neXtProt AC  NX_Q13255
Human Synonyms  GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13
Human Chr (Location)  6q24; chr6:146027782-146437646 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRM1
alleles, and
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(1) Spontaneous(5) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for null mutations show impairements in motor coordination, spatial learning, hippocampal mossy fiber long-term potentiation, and cerebellar long-term depression. Homozygotes for a spontaneous mutation are small and exhibit ataxia, kyphoscoliosis, albuminuria and glomerular damage.
Grm1 interacts with 388 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (48 annotations)
Process activation of MAPK activity, activation of MAPKK activity, ...
Component axon, cytosol, ...
Function estrogen receptor binding, glutamate receptor activity, ...
External Resources: FuncBase
Literature Summary: (17 records)
Data Summary: Results (332)    Tissues (194)    Images (52)
Theiler Stages: 19, 20, 22, 23, 28
Assay TypeResults
RNA in situ 227
In situ reporter (knock in) 67
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(14) cDNA(11) Primer pair(3)
Microarray probesets(2)
Other database
VEGA Gene ModelOTTMUSG00000016273 (Evidence)
Ensembl Gene ModelENSMUSG00000019828 (Evidence)
Entrez Gene14816 (Evidence)
DFCITC1586218, TC1596295, TC1658222
DoTSDT.101221786, DT.101715646, DT.55160665, DT.55240088
NIA Mouse Gene IndexU031538, U144988
Consensus CDS ProjectCCDS23696.1, CCDS48499.1
International Mouse Knockout Project StatusGrm1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016273 VEGA Gene Model | MGI Sequence Detail 396298 C57BL/6J ±  kb
transcript OTTMUST00000039039 VEGA | MGI Sequence Detail 6930 Not Applicable 
polypeptide OTTMUSP00000017441 VEGA | MGI Sequence Detail 1199 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(18) UniProt(3)
Polymorphisms SNPs within 2kb(2533 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2537)
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
InterPro IPR011500 GPCR, family 3, nine cysteines domain
InterPro IPR019588 Metabotropic glutamate receptor, Homer-binding domain
Protein Ontology PR:000008263 metabotropic glutamate receptor 1
References (Earliest) J:11894 Colon-Teicher L, et al., Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 1993 May 11;21(9):2223-8
(Latest) J:211480 Milanese M, et al., Knocking down metabotropic glutamate receptor 1 improves survival and disease progression in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2014 Apr;64:48-59
All references(123)
accession IDs
MGD-MRK-10264, MGI:1922125, MGI:2652657, MGI:3584411, MGI:3588965, MGI:95825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.19
The Jackson Laboratory