Grm1
Gene Detail

Symbol Name ID

Grm1 glutamate receptor, metabotropic 1 MGI:1351338

Synonyms

4930455H15Rik, Gprc1a, Grm1, mGluR1, nmf373, rcw

Feature Type

protein coding gene

Genetic Map

Chromosome 10

3.44 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:10686059-11082356 bp, - strand From VEGA annotation of GRCm38   396298 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Grm1 ± 2 cM)

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm1

Human ortholog

GRM1 glutamate receptor, metabotropic 1 NCBI Gene ID 2911
Human Synonyms: GPRC1A, GRM1A, mGlu1, MGLUR1, MGLUR1A, SCAR13
Human Chr6:146348782-146758731 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human GRM1 (1)

Alleles and phenotypes

All alleles(13) : Targeted(4) Gene trapped(1) Transgenic(1) Spontaneous(5) Chemically induced(2)
 

Mice homozygous for null mutations show impairements in motor coordination, spatial learning, hippocampal mossy fiber long-term potentiation, and cerebellar long-term depression. Homozygotes for a spontaneous mutation are small and exhibit ataxia, kyphoscoliosis, albuminuria and glomerular damage.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	activation of MAPK activity, activation of MAPKK activity, ...
Component	axon, dendrite, ...
Function	estrogen receptor binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (332)    Tissues (194)    Images (52)
Theiler Stages: 19, 20, 22, 23, 28

Assay Type	Results
RNA in situ	227
In situ reporter (knock in)	67
RT-PCR	38

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(11) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000016273 (Evidence)
Ensembl Gene Model	ENSMUSG00000019828 (Evidence)
Entrez Gene	14816 (Evidence)
DFCI	TC1586218, TC1596295, TC1658222
DoTS	DT.101221786, DT.101715646, DT.55160665, DT.55240088
NIA Mouse Gene Index	U031538, U144988
Consensus CDS Project	CCDS23696.1, CCDS48499.1
International Mouse Knockout Project Status	Grm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016273	VEGA Gene Model | MGI Sequence Detail	396298	C57BL/6J
transcript	OTTMUST00000039039	VEGA | MGI Sequence Detail	6930	Not Applicable
polypeptide	OTTMUSP00000017441	VEGA | MGI Sequence Detail	1199	Not Applicable

All sequences(45) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(1946 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017979	GPCR, family 3, conserved site
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR000162	GPCR, family 3, metabotropic glutamate receptor
InterPro	IPR001256	GPCR, family 3, metabotropic glutamate receptor 1
InterPro	IPR011500	GPCR, family 3, nine cysteines domain
InterPro	IPR019588	Metabotropic glutamate receptor, Homer-binding domain
Protein Ontology	PR:000008263	metabotropic glutamate receptor 1

References

(Earliest) J:11894 Colon-Teicher L, et al., Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 1993 May 11;21(9):2223-8
(Latest) J:192293 Kato AS, et al., Glutamate receptor delta2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cgamma, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons. J Neurosci. 2012 Oct 31;32(44):15296-308
All references(114)

Other accession IDs

MGD-MRK-10264, MGI:1922125, MGI:2652657, MGI:3584411, MGI:3588965, MGI:95825