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Grm1 Gene Detail
Summary
  • Symbol
    Grm1
  • Name
    glutamate receptor, metabotropic 1
  • Synonyms
    4930455H15Rik, Gprc1a, Grm1, mGluR1, nmf373, rcw
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351338
    NCBI Gene: 14816
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:10686059-11082356 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      396298 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 3.44 cM, cytoband A2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GRM1, glutamate metabotropic receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRM1, glutamate metabotropic receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13
  • Links
    NCBI Gene ID: 2911
    neXtProt AC: NX_Q13255
    UniProt: Q13255

  • Chr Location
    6q24.3; chr6:146027634-146437598 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Grm1 mouse models; 2 with human GRM1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 2 models
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 15 alleles in 15 genetic backgrounds
    4 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations show impairements in motor coordination, spatial learning, hippocampal mossy fiber long-term potentiation, and cerebellar long-term depression. Homozygotes for a spontaneous mutation are small and exhibit ataxia, kyphoscoliosis, albuminuria and glomerular damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016273 VEGA Gene Model | MGI Sequence Detail 396298 C57BL/6J ±  kb
    transcript OTTMUST00000039039 VEGA | MGI Sequence Detail 6930 Not Applicable  
    polypeptide OTTMUSP00000017441 VEGA | MGI Sequence Detail 1199 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2462 from dbSNP Build 142
    Protein
    Information
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    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008263 metabotropic glutamate receptor 1
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR019588 Metabotropic glutamate receptor, Homer-binding domain
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10264, MGI:1922125, MGI:2652657, MGI:3584411, MGI:3588965, MGI:95825
    References
    more
    • Summaries
      All 167
      Developmental Gene Expression 23
      Diseases 3
      Gene Ontology 16
      Phenotypes 71
    • Earliest
      J:11894 Colon-Teicher L, et al., Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 1993 May 11;21(9):2223-8
    • Latest
      J:263687 Wang CX, et al., METTL3-mediated m6A modification is required for cerebellar development. PLoS Biol. 2018 Jun;16(6):e2004880

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory