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Grm1
Gene Detail
Symbol

Name
ID
Grm1
glutamate receptor, metabotropic 1
MGI:1351338
Synonyms
4930455H15Rik, Gprc1a, Grm1, mGluR1, nmf373, rcw
Feature Type
protein coding gene
Genetic Map
Chromosome 10
3.44 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:10686059-11082356 bp, - strand
From VEGA annotation of GRCm38

  396298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:649  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRM1
Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm1

Human
homologs
GRM1, glutamate receptor, metabotropic 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2911
neXtProt AC: NX_Q13255

Human Synonyms: GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13

Human Chr (Location): 6q24; chr6:145964769-146437598 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GRM1

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(1) Spontaneous(5) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for null mutations show impairements in motor coordination, spatial learning, hippocampal mossy fiber long-term potentiation, and cerebellar long-term depression. Homozygotes for a spontaneous mutation are small and exhibit ataxia, kyphoscoliosis, albuminuria and glomerular damage.
 
Interactions
Grm1 interacts with 387 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process activation of MAPK activity, activation of MAPKK activity, ...
Component axon, cytosol, ...
Function estrogen receptor binding, glutamate receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (332)    Tissues (194)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 227
In situ reporter (knock in) 67
RT-PCR 38
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase grm1 ; ZFIN grm1a    NEW 
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000016273 (Evidence)
Ensembl Gene Model ENSMUSG00000019828 (Evidence)
Entrez Gene 14816 (Evidence)
DFCI TC1586218, TC1658222, TC1596295
DoTS DT.101715646, DT.101221786, DT.55160665, DT.55240088
NIA Mouse Gene Index U144988, U031538
Consensus CDS Project CCDS23696.1, CCDS48499.1
International Mouse Phenotyping Consortium Status Grm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016273 VEGA Gene Model | MGI Sequence Detail 396298 C57BL/6J ±  kb
transcript OTTMUST00000039039 VEGA | MGI Sequence Detail 6930 Not Applicable 
polypeptide OTTMUSP00000017441 VEGA | MGI Sequence Detail 1199 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(14) UniProt(3)
Polymorphisms
SNPs within 2kb(2533 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2537)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
InterPro IPR011500 GPCR, family 3, nine cysteines domain
InterPro IPR019588 Metabotropic glutamate receptor, Homer-binding domain
Protein Ontology PR:000008263 metabotropic glutamate receptor 1
References
(Earliest) J:11894 Colon-Teicher L, et al., Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 1993 May 11;21(9):2223-8
(Latest) J:219609 Maltecca F, et al., Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model. J Clin Invest. 2015 Jan;125(1):263-74
All references(123)
Other
accession IDs
MGD-MRK-10264, MGI:1922125, MGI:2652657, MGI:3584411, MGI:3588965, MGI:95825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory