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Grm1 Gene Detail
Summary
  • Symbol
    Grm1
  • Name
    glutamate receptor, metabotropic 1
  • Synonyms
    4930455H15Rik, Gprc1a, Grm1, mGluR1, nmf373, rcw
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351338
    NCBI Gene: 14816
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:10686059-11082356 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 3.44 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2462 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351338
protein coding gene Chr10:10686059-11082380 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017011
protein coding gene Chr10:8048758-8452053 (-)
A/J MGP_AJ_G0016989
protein coding gene Chr10:7664077-8063331 (-)
AKR/J MGP_AKRJ_G0016953
protein coding gene Chr10:7854241-8262948 (-)
BALB/cJ MGP_BALBcJ_G0016947
protein coding gene Chr10:7653208-8077808 (-)
C3H/HeJ MGP_C3HHeJ_G0016772
protein coding gene Chr10:8017958-8422530 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017409
protein coding gene Chr10:8221470-8652121 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015114
protein coding gene Chr10:7084424-7468042 (-)
CAST/EiJ MGP_CASTEiJ_G0016354
protein coding gene Chr10:7886598-8289687 (-)
CBA/J MGP_CBAJ_G0016744
protein coding gene Chr10:8509539-8955487 (-)
DBA/2J MGP_DBA2J_G0016852
protein coding gene Chr10:7594391-7982108 (-)
FVB/NJ MGP_FVBNJ_G0016847
protein coding gene Chr10:7506259-7885555 (-)
LP/J MGP_LPJ_G0016927
protein coding gene Chr10:7838139-8247079 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016877
protein coding gene Chr10:8428458-8863737 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017447
protein coding gene Chr10:7800115-8197861 (-)
PWK/PhJ MGP_PWKPhJ_G0016139
protein coding gene Chr10:7511320-7901855 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015922
protein coding gene Chr10:7833058-8245697 (-)
WSB/EiJ MGP_WSBEiJ_G0016416
protein coding gene Chr10:7798911-8219059 (-)



Homology
more
  • Human Ortholog
    GRM1, glutamate metabotropic receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRM1, glutamate metabotropic receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13
  • Links
    NCBI Gene ID: 2911
    neXtProt AC: NX_Q13255
    UniProt: Q13255

  • Chr Location
    6q24.3; chr6:146027634-146437598 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    3 with Grm1 mouse models; 2 with human GRM1 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 2 models
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 15 alleles in 15 genetic backgrounds
    4 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations show impairements in motor coordination, spatial learning, hippocampal mossy fiber long-term potentiation, and cerebellar long-term depression. Homozygotes for a spontaneous mutation are small and exhibit ataxia, kyphoscoliosis, albuminuria and glomerular damage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019828 Ensembl Gene Model | MGI Sequence Detail 396298 C57BL/6J ±  kb
    transcript ENSMUST00000044306 Ensembl | MGI Sequence Detail 6930 Not Applicable  
    polypeptide ENSMUSP00000037255 Ensembl | MGI Sequence Detail 1199 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008263 metabotropic glutamate receptor 1
    • InterPro Domains
      IPR000337 GPCR, family 3
      IPR017979 GPCR, family 3, conserved site
      IPR017978 GPCR family 3, C-terminal
      IPR000162 GPCR, family 3, metabotropic glutamate receptor
      IPR001256 GPCR, family 3, metabotropic glutamate receptor 1
      IPR011500 GPCR, family 3, nine cysteines domain
      IPR038550 GPCR, family 3, nine cysteines domain superfamily
      IPR019588 Metabotropic glutamate receptor, Homer-binding domain
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 13
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10264, MGI:1922125, MGI:2652657, MGI:3584411, MGI:3588965, MGI:95825
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 24
      Diseases 3
      Gene Ontology 17
      Phenotypes 71
    • Earliest
      J:11894 Colon-Teicher L, et al., Genomic sequences capable of committing mouse and rat fibroblasts to adipogenesis. Nucleic Acids Res. 1993 May 11;21(9):2223-8
    • Latest
      J:264379 Cardenas A, et al., Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell. 2018 Jul 26;174(3):590-606.e21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory