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Ddx24 Gene Detail
Summary
  • Symbol
    Ddx24
  • Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 24
  • Synonyms
    1700055J08Rik, 2510027P10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351337
    NCBI Gene: 27225
  • Gene Overview
    MyGene.info: DDX24
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:103407982-103425830 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17849 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 52.92 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DDX24, DEAD-box helicase 24
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDX24, DEAD-box helicase 24
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 57062
    neXtProt AC: NX_Q9GZR7
    UniProt: Q9GZR7

  • Chr Location
    14q32.12; chr14:94050922-94081212 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10702
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DDX24
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is embryonic lethal: embryos die between implantation and placentation. Heterozygous KO animals are viable and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041645 Ensembl Gene Model | MGI Sequence Detail 17849 C57BL/6J ±  kb
transcript ENSMUST00000110001 Ensembl | MGI Sequence Detail 3063 Not Applicable  
polypeptide ENSMUSP00000105628 Ensembl | MGI Sequence Detail 903 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    183 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 232
    cDNA 232

    Microarray probesets 5
Other
Accession IDs
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MGI:1919702, MGI:1925876, MGI:2144875
References
more
  • Summaries
    All 32
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:63823 Zhao Y, et al., Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-Box proteins, and mapping DDX24 to human chromosome 14q32. Genomics. 2000 Aug 1;67(3):351-5
  • Latest
    J:246298 Ma Z, et al., DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling. PLoS Pathog. 2013 Oct;9(10):e1003721

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/17/2018
MGI 6.11
The Jackson Laboratory