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Atp1a4 Gene Detail
Summary
  • Symbol
    Atp1a4
  • Name
    ATPase, Na+/K+ transporting, alpha 4 polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351335
    NCBI Gene: 27222
  • Gene Overview
    MyGene.info: ATP1A4
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172223513-172258414 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    398 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351335
protein coding gene Chr1:172223508-172258424 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016782
protein coding gene Chr1:178081748-178120282 (-)
A/J MGP_AJ_G0016761
protein coding gene Chr1:170791961-170829037 (-)
AKR/J MGP_AKRJ_G0016727
protein coding gene Chr1:175954404-175991662 (-)
BALB/cJ MGP_BALBcJ_G0016722
protein coding gene Chr1:171338908-171374924 (-)
C3H/HeJ MGP_C3HHeJ_G0016546
protein coding gene Chr1:176527897-176564116 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017184
protein coding gene Chr1:183993474-184028294 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014890
protein coding gene Chr1:162496497-162531683 (-)
CAST/EiJ MGP_CASTEiJ_G0016126
protein coding gene Chr1:175889779-175930353 (-)
CBA/J MGP_CBAJ_G0016520
protein coding gene Chr1:190544349-190580114 (-)
DBA/2J MGP_DBA2J_G0016627
protein coding gene Chr1:169728954-169765140 (-)
FVB/NJ MGP_FVBNJ_G0016624
protein coding gene Chr1:167985084-168020882 (-)
LP/J MGP_LPJ_G0016698
protein coding gene Chr1:179175332-179212740 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016651
protein coding gene Chr1:197791515-197828032 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017220
protein coding gene Chr1:175824247-175859906 (-)
PWK/PhJ MGP_PWKPhJ_G0015912
protein coding gene Chr1:169104676-169141100 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015694
protein coding gene Chr1:174774010-174809754 (-)
WSB/EiJ MGP_WSBEiJ_G0016188
protein coding gene Chr1:175979561-176016452 (-)



Homology
more
  • Human Ortholog
    ATP1A4, ATPase Na+/K+ transporting subunit alpha 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ATP1A4, ATPase Na+/K+ transporting subunit alpha 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATP1A1, ATP1AL2
  • Links
    NCBI Gene ID: 480
    neXtProt AC: NX_Q13733
    UniProt: Q13733

  • Chr Location
    1q23.2; chr1:160151562-160186977 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele exhibit infertility associated with asthenozoospermia and teratozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007107 Ensembl Gene Model | MGI Sequence Detail 34902 C57BL/6J ±  kb
    transcript ENSMUST00000111243 Ensembl | MGI Sequence Detail 3470 Not Applicable  
    polypeptide ENSMUSP00000106874 Ensembl | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 11
      cDNA 9
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:58404 Underhill DA, et al., The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Biochemistry. 1999 Nov 9;38(45):14746-51
    • Latest
      J:251823 Takagishi M, et al., Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus. Cell Rep. 2017 Jul 25;20(4):960-972

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory