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Atp1a4
Gene Detail
Symbol

Name
ID
Atp1a4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
MGI:1351335
Feature Type
protein coding gene
Genetic Map
Chromosome 1
79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:172223513-172258414 bp, - strand
From VEGA annotation of GRCm38

  34902 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a4

Human
homologs
Human Homolog ATP1A4, ATPase, Na+/K+ transporting, alpha 4 polypeptide
NCBI Gene ID 480
neXtProt AC  NX_Q13733
Human Synonyms  ATP1A1, ATP1AL2
Human Chr (Location)  1q23.2; chr1:160151562-160186977 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for a knock-out allele exhibit infertility associated with asthenozoospermia and teratozoospermia.
 
Interactions
Atp1a4 interacts with 45 markers (Mir26a-1, Mir29a, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process ATP catabolic process, fertilization, ...
Component cell, integral component of membrane, ...
Function ATP binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (108)    Tissues (104)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 14
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(11) cDNA(8) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000021836 (Evidence)
Ensembl Gene ModelENSMUSG00000007107 (Evidence)
Entrez Gene27222 (Evidence)
UniGene482392
NIA Mouse Gene IndexU114925
EC3.6.3.9
Consensus CDS ProjectCCDS48446.1
International Mouse Knockout Project StatusAtp1a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021836 VEGA Gene Model | MGI Sequence Detail 34902 C57BL/6J ±  kb
transcript OTTMUST00000051822 VEGA | MGI Sequence Detail 3470 Not Applicable 
polypeptide OTTMUSP00000024456 VEGA | MGI Sequence Detail 1032 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(411 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR006068 Cation-transporting P-type ATPase, C-terminal
InterPro IPR004014 Cation-transporting P-type ATPase, N-terminal
InterPro IPR023214 HAD-like domain
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
InterPro IPR023298 P-type ATPase, transmembrane domain
InterPro IPR005775 Sodium/potassium-transporting P-type ATPase, subfamily IIC
Protein Ontology PR:000004438 sodium/potassium-transporting ATPase subunit alpha-4
References
(Earliest) J:58404 Underhill DA, et al., The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Biochemistry. 1999 Nov 9;38(45):14746-51
(Latest) J:203477 McDermott JP, et al., Green fluorescence protein driven by the Na,K-ATPase alpha4 isoform promoter is expressed only in male germ cells of mouse testis. J Assist Reprod Genet. 2012 Dec;29(12):1313-25
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory