Atp1a4
Gene Detail

Symbol Name ID

Atp1a4 ATPase, Na+/K+ transporting, alpha 4 polypeptide MGI:1351335

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:172223513-172258414 bp, - strand From VEGA annotation of GRCm38   34902 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Na(+)/K(+)-transporting ATPase alpha chain
Gene Tree: Atp1a4

Human homologs

Human Homolog		ATP1A4, ATPase, Na+/K+ transporting, alpha 4 polypeptide
NCBI Gene ID		480
neXtProt AC		NX_Q13733
Human Synonyms		ATP1A1, ATP1AL2
Human Chr (Location)		1q23.2; chr1:160121352-160156767 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Male mice homozygous for a knock-out allele exhibit infertility associated with asthenozoospermia and teratozoospermia.

 

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	ATP biosynthetic process, ATP catabolic process, ...
Component	integral to membrane, membrane, ...
Function	ATP binding, cation-transporting ATPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (116)    Tissues (109)    Images (1)
Theiler Stages: 2, 3, 4, 5, 13, 15, 17, 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	22

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(22) Genomic(11) cDNA(8) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000021836 (Evidence)
Ensembl Gene Model	ENSMUSG00000007107 (Evidence)
Entrez Gene	27222 (Evidence)
UniGene	482392
NIA Mouse Gene Index	U114925
EC	3.6.3.9
Consensus CDS Project	CCDS48446.1
International Mouse Knockout Project Status	Atp1a4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021836	VEGA Gene Model | MGI Sequence Detail	34902	C57BL/6J
transcript	OTTMUST00000051822	VEGA | MGI Sequence Detail	3470	Not Applicable
polypeptide	OTTMUSP00000024456	VEGA | MGI Sequence Detail	1032	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Protein-related information

Resource	ID	Description
InterPro	IPR023306	ATPase, cation-transporting, domain N
InterPro	IPR008250	ATPase, P-type, ATPase-associated domain
InterPro	IPR006069	ATPase, P-type cation exchange, alpha subunit
InterPro	IPR005775	ATPase, P-type cation exchange, alpha subunit, eukaryotic
InterPro	IPR006068	ATPase, P-type cation-transporter, C-terminal
InterPro	IPR004014	ATPase, P-type cation-transporter, N-terminal
InterPro	IPR023299	ATPase, P-type, cytoplasmic domain N
InterPro	IPR023300	ATPase, P-type, cytoplasmic transduction domain A
InterPro	IPR001757	ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter
InterPro	IPR018303	ATPase, P-type phosphorylation site
InterPro	IPR023298	ATPase, P-type, transmembrane domain
InterPro	IPR023214	HAD-like domain
InterPro	IPR005834	Haloacid dehalogenase-like hydrolase
Protein Ontology	PR:000004438	sodium/potassium-transporting ATPase subunit alpha-4

References

(Earliest) J:58404 Underhill DA, et al., The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Biochemistry. 1999 Nov 9;38(45):14746-51
(Latest) J:179935 Seo-Mayer PW, et al., Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia. Am J Physiol Renal Physiol. 2011 Dec;301(6):F1346-57
All references(33)