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Atp1a4 Gene Detail
Summary
  • Symbol
    Atp1a4
  • Name
    ATPase, Na+/K+ transporting, alpha 4 polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351335
    NCBI Gene: 27222
  • Gene Overview
    MyGene.info: ATP1A4
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:172223513-172258414 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34902 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ATP1A4, ATPase Na+/K+ transporting subunit alpha 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ATP1A4, ATPase Na+/K+ transporting subunit alpha 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATP1A1, ATP1AL2
  • Links
    NCBI Gene ID: 480
    neXtProt AC: NX_Q13733
    UniProt: Q13733

  • Chr Location
    1q23.2; chr1:160151562-160186977 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele exhibit infertility associated with asthenozoospermia and teratozoospermia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021836 VEGA Gene Model | MGI Sequence Detail 34902 C57BL/6J ±  kb
    transcript OTTMUST00000051822 VEGA | MGI Sequence Detail 3470 Not Applicable  
    polypeptide OTTMUSP00000024456 VEGA | MGI Sequence Detail 1032 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      398 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 11
      cDNA 8
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:58404 Underhill DA, et al., The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1. Biochemistry. 1999 Nov 9;38(45):14746-51
    • Latest
      J:251823 Takagishi M, et al., Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus. Cell Rep. 2017 Jul 25;20(4):960-972

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory