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Syn3
Gene Detail
 Symbol
Name
ID
Syn3
synapsin III
MGI:1351334
Synonyms Synapsin IIIa
Feature Type protein coding gene
Genetic Map
Chromosome 10
41.95 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:86055125-86498896 bp, - strand
From VEGA annotation of GRCm38

  443772 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Syn3

Human
homologs
Human Homolog SYN3, synapsin III
NCBI Gene ID 8224
neXtProt AC  NX_O14994
Human Chr (Location)  22q12.3; chr22:32512552-33058391 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(5) Gene trapped(3)
 
Mice homozygous for a knock-out allele display altered neurotransmitter release, reduced synaptic depression, and a specific delay in early axon outgrowth in cultured hippocampal neurons.
 
Human Diseases Modeled Using Mouse Syn3 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process neurotransmitter secretion
Component cell junction, cytoplasmic vesicle, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000028681 (Evidence)
Ensembl Gene ModelENSMUSG00000059602 (Evidence)
Entrez Gene27204 (Evidence)
Consensus CDS ProjectCCDS24096.1, CCDS48659.1
International Mouse Knockout Project StatusSyn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028681 VEGA Gene Model | MGI Sequence Detail 443772 C57BL/6J ±  kb
transcript OTTMUST00000071040 VEGA | MGI Sequence Detail 2360 Not Applicable 
polypeptide OTTMUSP00000036313 VEGA | MGI Sequence Detail 579 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(2751 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR016185 Pre-ATP-grasp domain
InterPro IPR001359 Synapsin
InterPro IPR020898 Synapsin, ATP-binding domain
InterPro IPR019735 Synapsin, conserved site
InterPro IPR019736 Synapsin, phosphorylation site
InterPro IPR020897 Synapsin, pre-ATP-grasp domain
Protein Ontology PR:000015872 synapsin-3
References (Earliest) J:59378 Kao HT, et al., A third member of the synapsin gene family. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4667-72
(Latest) J:206996 Farisello P, et al., Synaptic and extrasynaptic origin of the excitation/inhibition imbalance in the hippocampus of synapsin I/II/III knockout mice. Cereb Cortex. 2013 Mar;23(3):581-93
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory