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Syn3 Gene Detail
Summary
  • Symbol
    Syn3
  • Name
    synapsin III
  • Synonyms
    Synapsin IIIa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351334
    NCBI Gene: 27204
Location & Maps
more
  • Sequence Map
    Chr10:86055125-86498896 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      443772 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SYN3, synapsin III
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SYN3, synapsin III
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 8224
    neXtProt AC: NX_O14994

  • Chr Location
    22q12.3; chr22:32508022-33058391 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68320
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: SYN3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Syn3 mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    5
  • Genomic Mutations
    1 involving Syn3
  • Incidental Mutations
Mice homozygous for a knock-out allele display altered neurotransmitter release, reduced synaptic depression, and a specific delay in early axon outgrowth in cultured hippocampal neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028681 VEGA Gene Model | MGI Sequence Detail 443772 C57BL/6J ±  kb
transcript OTTMUST00000071040 VEGA | MGI Sequence Detail 2360 Not Applicable  
polypeptide OTTMUSP00000036313 VEGA | MGI Sequence Detail 579 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2751 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 2
References
more
  • Summaries
    All 48
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 27
  • Earliest
    J:59378 Kao HT, et al., A third member of the synapsin gene family. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4667-72
  • Latest
    J:220585 Ketzef M, et al., Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex. Cereb Cortex. 2014 Apr;24(4):996-1008

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory