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Chaf1a Gene Detail
Summary
  • Symbol
    Chaf1a
  • Name
    chromatin assembly factor 1, subunit A (p150)
  • Synonyms
    CAF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351331
    NCBI Gene: 27221
  • Gene Overview
    MyGene.info: CHAF1A
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56040416-56068026 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.13 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351331
protein coding gene Chr17:56040416-56068026 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023909
protein coding gene Chr17:57670615-57705666 (+)
A/J MGP_AJ_G0023869
protein coding gene Chr17:56113969-56144537 (+)
AKR/J MGP_AKRJ_G0023838
protein coding gene Chr17:56797876-56827997 (+)
BALB/cJ MGP_BALBcJ_G0023870
protein coding gene Chr17:55948890-55979686 (+)
C3H/HeJ MGP_C3HHeJ_G0023633
protein coding gene Chr17:57505411-57533307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024314
protein coding gene Chr17:59952976-59995808 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021761
protein coding gene Chr17:52630603-52658026 (+)
CAST/EiJ MGP_CASTEiJ_G0023116
protein coding gene Chr17:57816687-57851390 (+)
CBA/J MGP_CBAJ_G0023610
protein coding gene Chr17:62258529-62287849 (+)
DBA/2J MGP_DBA2J_G0023738
protein coding gene Chr17:54846822-54874191 (+)
FVB/NJ MGP_FVBNJ_G0023704
protein coding gene Chr17:54365790-54394050 (+)
LP/J MGP_LPJ_G0023818
protein coding gene Chr17:58388547-58417079 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023731
protein coding gene Chr17:61815412-61844841 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024359
protein coding gene Chr17:57172190-57201551 (+)
PWK/PhJ MGP_PWKPhJ_G0022861
protein coding gene Chr17:54189475-54217289 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022673
protein coding gene Chr17:53939898-53973316 (+)
WSB/EiJ MGP_WSBEiJ_G0023180
protein coding gene Chr17:57785733-57819254 (+)



Homology
more
  • Human Ortholog
    CHAF1A, chromatin assembly factor 1 subunit A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHAF1A, chromatin assembly factor 1 subunit A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAF1, CAF-1, CAF1B, CAF1P150, P150
  • Links
    NCBI Gene ID: 10036
    neXtProt AC: NX_Q13111
    UniProt: Q13111

  • Chr Location
    19p13.3; chr19:4402596-4448322 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation in this gene display lethality before implantation, embryonic growth arrest, and abnormal heterochromatin morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27221 NCBI Gene Model | MGI Sequence Detail 27611 C57BL/6J ±  kb
transcript NM_013733 RefSeq | MGI Sequence Detail 3308 C57BL/6  
polypeptide Q9QWF0 UniProt | EBI | MGI Sequence Detail 911 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005402 chromatin assembly factor 1 subunit A
  • PDB
  • InterPro Domains
    IPR022043 Chromatin assembly factor 1 subunit A
    IPR029105 Chromatin assembly factor 1 subunit A, C-terminal
    IPR029091 Chromatin assembly factor 1 subunit A, N-terminal
Molecular
Reagents
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  • All nucleic 9
    cDNA 9

    Microarray probesets 3
Other
Accession IDs
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MGI:2146952, MGI:2146957
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:58148 Murzina N, et al., Heterochromatin dynamics in mouse cells: interaction between chromatin assembly factor 1 and HP1 proteins. Mol Cell. 1999 Oct;4(4):529-40
  • Latest
    J:228290 Cheloufi S, et al., The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 2015 Dec 10;528(7581):218-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory