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Cartpt
Gene Detail
Symbol

Name
ID
Cartpt
CART prepropeptide
MGI:1351330
Synonyms
Cart
Feature Type
protein coding gene
Genetic Map
Chromosome 13
52.90 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:99898484-99900683 bp, - strand
From Ensembl annotation of GRCm38

  2200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3169  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: CARTPT
Gene Tree: Cartpt

Human
homologs
CARTPT, CART prepropeptide
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9607
neXtProt AC: NX_Q16568

Human Synonyms: CART

Human Chr (Location): 5q13.2; chr5:71719163-71721048 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CARTPT

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Homozygous null mice exhibit increases in food consumption, body weight, and fat mass when fed a high-fat diet, but not on a regular diet. Mice homozygous for another disruption in this gene have increased body weight at older ages, impaired insulin secretion and glucose intolerance.
 
Interactions
Cartpt interacts with 73 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process activation of MAPKK activity, adult feeding behavior, ...
Component extracellular region, extracellular space, ...
Function neuropeptide hormone activity
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (145)    Tissues (37)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
cDNA source data(11)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cartpt    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021647 (Evidence)
Entrez Gene 27220 (Evidence)
UniGene 75498
DFCI TC1640938, TC1587601
DoTS DT.94168677, DT.482097
NIA Mouse Gene Index U035100
Consensus CDS Project CCDS36763.1
International Mouse Phenotyping Consortium Status Cartpt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021647 Ensembl Gene Model | MGI Sequence Detail 2200 C57BL/6J ±  kb
transcript ENSMUST00000022150 Ensembl | MGI Sequence Detail 874 Not Applicable 
polypeptide ENSMUSP00000022150 Ensembl | MGI Sequence Detail 129 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)    SNPs within 2kb including multiple locations(40)
Protein-related
information
ResourceIDDescription
InterPro IPR009106 CART satiety factor
Protein Ontology PR:000005046 cocaine- and amphetamine-regulated transcript protein
References
(Earliest) J:47476 Kristensen P, et al., Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998 May 7;393(6680):72-6
(Latest) J:220735 Wu F, et al., Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory