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Cartpt Gene Detail
Summary
  • Symbol
    Cartpt
  • Name
    CART prepropeptide
  • Synonyms
    Cart
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351330
    NCBI Gene: 27220
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100034991-100037191 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 52.90 cM, cytoband D1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351330
 protein coding gene Chr13:100034991-100037599 (-)
129S1/SvImJ ENSMUSG00200007630
 protein coding gene Chr13:94606644-94609257 (-)
A/J ENSMUSG00195027585
 protein coding gene Chr13:95073102-95075711 (-)
AKR/J ENSMUSG00220025400
 protein coding gene Chr13:93560684-93563292 (-)
BALB/cJ ENSMUSG00180036792
 protein coding gene Chr13:95607554-95610161 (-)
C3H/HeJ ENSMUSG00175014542
 protein coding gene Chr13:95774394-95777001 (-)
C57BL/6NJ ENSMUSG00215015141
 protein coding gene Chr13:95686680-95689283 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018832
 protein coding gene Chr13:93523963-93526128 (-)
CAST/EiJ ENSTCUG00005010891
 protein coding gene Chr13:94883909-94886513 (-)
CBA/J ENSMUSG00210011413
 protein coding gene Chr13:95112123-95114745 (-)
DBA/2J ENSMUSG00185018349
 protein coding gene Chr13:98773123-98775742 (-)
FVB/NJ ENSMUSG00205025726
 protein coding gene Chr13:94555141-94557747 (-)
JF1/MsJ ENSUMUG00000021056
 protein coding gene Chr13:98444745-98447337 (-)
LP/J ENSMUSG00230034584
 protein coding gene Chr13:108791840-108794452 (-)
NOD/ShiLtJ ENSMUSG00190039274
 protein coding gene Chr13:95437600-95440206 (-)
NZO/HlLtJ ENSMUSG00225032677
 protein coding gene Chr13:101287456-101290064 (-)
PWK/PhJ ENSLUMG00010022982
 protein coding gene Chr13:94538544-94541167 (-)
SPRET/EiJ ENSMSPG00010008366
 protein coding gene Chr13:95886628-95889260 (-)
WSB/EiJ ENSIUOG00005031571
 protein coding gene Chr13:94439373-94441990 (-)



Homology
more
  • Human Ortholog
    CARTPT, CART prepropeptide
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARTPT, CART prepropeptide
  • Synonyms
    CART
  • Links
    NCBI Gene ID: 9607
    UniProt: Q16568

  • Chr Location
    5q13.2; chr5:71719275-71721048 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CARTPT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit increases in food consumption, body weight, and fat mass when fed a high-fat diet, but not on a regular diet. Mice homozygous for another disruption in this gene have increased body weight at older ages, impaired insulin secretion and glucose intolerance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    142
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    62
  • cDNA Data
    13
  • Literature Summary
    41
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27220 NCBI Gene Model | MGI Sequence Detail 2201 C57BL/6J ±  kb
    transcript NM_013732 RefSeq | MGI Sequence Detail 875 Not Specified  
    polypeptide P56388 UniProt | EBI | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 14
      Primer pair 1
      Other 3
      Antibodies 5

      Microarray probesets 3
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 41
      Gene Ontology 13
      Phenotypes 49
    • Earliest
      J:47476 Kristensen P, et al., Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998 May 7;393(6680):72-6
    • Latest
      J:389408 Kumar S, et al., A distinct vagus-beta cell neural circuit senses glucose and modulates insulin secretion. Mol Metab. 2026 Apr 21;108:102371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory