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Cartpt
Gene Detail
Symbol

Name
ID
Cartpt
CART prepropeptide
MGI:1351330
Synonyms
Cart
Feature Type
protein coding gene
Genetic Map
Chromosome 13
52.90 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:99898484-99900683 bp, - strand
From Ensembl annotation of GRCm38

  2200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3169  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Cartpt

Human
homologs
Human Homolog CARTPT, CART prepropeptide
NCBI Gene ID 9607
neXtProt AC  NX_Q16568
Human Synonyms  CART
Human Chr (Location)  5q13.2; chr5:71719163-71721048 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CARTPT
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Homozygous null mice exhibit increases in food consumption, body weight, and fat mass when fed a high-fat diet, but not on a regular diet. Mice homozygous for another disruption in this gene have increased body weight at older ages, impaired insulin secretion and glucose intolerance.
 
Interactions
Cartpt interacts with 73 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process activation of MAPKK activity, adult feeding behavior, ...
Component extracellular region, extracellular space, ...
Function neuropeptide hormone activity
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (145)    Tissues (37)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021647 (Evidence)
Entrez Gene27220 (Evidence)
UniGene75498
DFCITC1640938, TC1587601
DoTSDT.482097, DT.94168677
NIA Mouse Gene IndexU035100
Consensus CDS ProjectCCDS36763.1
International Mouse Knockout Project StatusCartpt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021647 Ensembl Gene Model | MGI Sequence Detail 2200 C57BL/6J ±  kb
transcript ENSMUST00000022150 Ensembl | MGI Sequence Detail 874 Not Applicable 
polypeptide ENSMUSP00000022150 Ensembl | MGI Sequence Detail 129 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(36 from dbSNP Build 137)    SNPs within 2kb including multiple locations(40)
Protein-related
information
ResourceIDDescription
InterPro IPR009106 CART satiety factor
Protein Ontology PR:000005046 cocaine- and amphetamine-regulated transcript protein
References
(Earliest) J:47476 Kristensen P, et al., Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998 May 7;393(6680):72-6
(Latest) J:201201 Anthwal N, et al., Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Dis Model Mech. 2013 Sep-Oct;6(5):1133-45
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory