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Cartpt Gene Detail
Summary
  • Symbol
    Cartpt
  • Name
    CART prepropeptide
  • Synonyms
    Cart
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351330
    NCBI Gene: 27220
Location & Maps
more
  • Sequence Map
    Chr13:99898484-99900683 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2200 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 52.90 cM, cytoband D1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CARTPT, CART prepropeptide
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CARTPT, CART prepropeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CART
  • Links
    NCBI Gene ID: 9607
    neXtProt AC: NX_Q16568

  • Chr Location
    5q13.2; chr5:71719163-71721048 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CARTPT associations

Human Disease Mouse Models
       Obesity   OMIM: 601665
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Targeted
    3
  • Incidental Mutations
    APF
Homozygous null mice exhibit increases in food consumption, body weight, and fat mass when fed a high-fat diet, but not on a regular diet. Mice homozygous for another disruption in this gene have increased body weight at older ages, impaired insulin secretion and glucose intolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021647 Ensembl Gene Model | MGI Sequence Detail 2200 C57BL/6J ±  kb
transcript ENSMUST00000022150 Ensembl | MGI Sequence Detail 874 Not Applicable  
polypeptide ENSMUSP00000022150 Ensembl | MGI Sequence Detail 129 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    33 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 17
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:47476 Kristensen P, et al., Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 1998 May 7;393(6680):72-6
  • Latest
    J:235958 Rousso DL, et al., Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep. 2016 May 31;15(9):1930-44

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory