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Pla2g7
Gene Detail
 Symbol
Name
ID
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
MGI:1351327
Synonyms PAF acetylhydrolase
Feature Type protein coding gene
Genetic Map
Chromosome 17
19.74 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:43568098-43612201 bp, + strand
From VEGA annotation of GRCm38

  44104 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: PAF acetylhydrolase
Gene Tree: Pla2g7

Human
homologs
Human Homolog PLA2G7, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
NCBI Gene ID 7941
neXtProt AC  NX_Q13093
Human Synonyms  LDL-PLA2, LP-PLA2, PAFAD, PAFAH
Human Chr (Location)  6p21.2-p12; chr6:46704316-46735693 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PLA2G7
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pla2g7 interacts with 61 markers (Mir24-1, Mir24-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process inflammatory response, lipid catabolic process, ...
Component cytoplasm, extracellular region, ...
Function 1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium-independent phospholipase A2 activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (269)    Tissues (142)    Images (39)
Theiler Stages: 11, 13, 19, 22, 23, 28
Assay TypeResults
RNA in situ 240
RT-PCR 29
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026307 (Evidence)
Ensembl Gene ModelENSMUSG00000023913 (Evidence)
Entrez Gene27226 (Evidence)
DFCITC1575197, TC1595303, TC1663272
DoTSDT.101399886, DT.489494, DT.94181217
NIA Mouse Gene IndexU018006
EC3.1.1.47
Consensus CDS ProjectCCDS28796.1
International Mouse Knockout Project StatusPla2g7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026307 VEGA Gene Model | MGI Sequence Detail 44104 C57BL/6J ±  kb
transcript OTTMUST00000065070 VEGA | MGI Sequence Detail 2097 Not Applicable 
polypeptide OTTMUSP00000032378 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(383 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016715 PAF acetylhydrolase
InterPro IPR005065 Platelet-activating factor acetylhydrolase
Protein Ontology PR:000012812 platelet-activating factor acetylhydrolase
References (Earliest) J:29539 Tjoelker LW, et al., Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad. J Biol Chem. 1995 Oct 27;270(43):25481-7
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(44)
Other
accession IDs
MGI:2147157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory