Pla2g7
Gene Detail

Symbol Name ID

Pla2g7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) MGI:1351327

Synonyms

PAF acetylhydrolase

Feature Type

protein coding gene

Genetic Map

Chromosome 17

19.74 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:43568098-43612201 bp, + strand From VEGA annotation of GRCm38   44104 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: PAF acetylhydrolase
Gene Tree: Pla2g7

Human homologs

Human Homolog		PLA2G7, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
NCBI Gene ID		7941
neXtProt AC		NX_Q13093
Human Synonyms		LDL-PLA2, LP-PLA2, PAFAD, PAFAH
Human Chr (Location)		6p21.2-p12; chr6:46672053-46703430 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human PLA2G7

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	inflammatory response, lipid catabolic process, ...
Component	extracellular region, low-density lipoprotein particle
Function	1-alkyl-2-acetylglycerophosphocholine esterase activity, calcium-independent phospholipase A2 activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (269)    Tissues (142)    Images (39)
Theiler Stages: 11, 13, 19, 22, 23, 28

Assay Type	Results
RNA in situ	240
RT-PCR	29

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026307 (Evidence)
Ensembl Gene Model	ENSMUSG00000023913 (Evidence)
Entrez Gene	27226 (Evidence)
DFCI	TC1575197, TC1595303, TC1663272
DoTS	DT.101399886, DT.489494, DT.94181217
NIA Mouse Gene Index	U018006
EC	3.1.1.47
Consensus CDS Project	CCDS28796.1
International Mouse Knockout Project Status	Pla2g7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026307	VEGA Gene Model | MGI Sequence Detail	44104	C57BL/6J
transcript	OTTMUST00000065070	VEGA | MGI Sequence Detail	2097	Not Applicable
polypeptide	OTTMUSP00000032378	VEGA | MGI Sequence Detail	440	Not Applicable

All sequences(48) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(331 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016715	PAF acetylhydrolase
InterPro	IPR005065	Platelet-activating factor acetylhydrolase
Protein Ontology	PR:000012812	platelet-activating factor acetylhydrolase

References

(Earliest) J:29539 Tjoelker LW, et al., Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad. J Biol Chem. 1995 Oct 27;270(43):25481-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)

Other accession IDs

MGI:2147157