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Pla2g7
Gene Detail
Symbol

Name
ID
Pla2g7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
MGI:1351327
Synonyms
PAF acetylhydrolase
Feature Type
protein coding gene
Genetic Map
Chromosome 17
19.74 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:43568098-43612201 bp, + strand
From VEGA annotation of GRCm38

  44104 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3725  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLA2G7
Protein SuperFamily: PAF acetylhydrolase
Gene Tree: Pla2g7

Human
homologs
PLA2G7, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7941
neXtProt AC: NX_Q13093

Human Synonyms: LDL-PLA2, LP-PLA2, PAFAD, PAFAH

Human Chr (Location): 6p21.2-p12; chr6:46704316-46735701 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human PLA2G7

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Pla2g7 interacts with 61 markers (Mir24-1, Mir24-2, Mir34b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (269)    Tissues (142)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 240
RT-PCR 29
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pla2g7 ; ZFIN pla2g7    NEW 
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026307 (Evidence)
Ensembl Gene Model ENSMUSG00000023913 (Evidence)
Entrez Gene 27226 (Evidence)
DFCI TC1575197, TC1595303, TC1663272
DoTS DT.101399886, DT.489494, DT.94181217
NIA Mouse Gene Index U018006
EC 3.1.1.47
Consensus CDS Project CCDS28796.1
International Mouse Phenotyping Consortium Status Pla2g7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026307 VEGA Gene Model | MGI Sequence Detail 44104 C57BL/6J ±  kb
transcript OTTMUST00000065070 VEGA | MGI Sequence Detail 2097 Not Applicable 
polypeptide OTTMUSP00000032378 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(8) UniProt(6)
Polymorphisms
SNPs within 2kb(383 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016715 PAF acetylhydrolase
InterPro IPR005065 Platelet-activating factor acetylhydrolase
Protein Ontology PR:000012812 platelet-activating factor acetylhydrolase
References
(Earliest) J:29539 Tjoelker LW, et al., Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad. J Biol Chem. 1995 Oct 27;270(43):25481-7
(Latest) J:218423 Agrawal V, et al., Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod. 2014 Nov;91(5):119
All references(44)
Other
accession IDs
MGI:2147157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory