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Pla2g7 Gene Detail
Summary
  • Symbol
    Pla2g7
  • Name
    phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
  • Synonyms
    PAF acetylhydrolase, PAF-AH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351327
    NCBI Gene: 27226
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43568098-43612201 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 19.74 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    375 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351327
protein coding gene Chr17:43568081-43612202 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023776
protein coding gene Chr17:44461638-44511119 (+)
A/J MGP_AJ_G0023734
protein coding gene Chr17:43462259-43507701 (+)
AKR/J MGP_AKRJ_G0023705
protein coding gene Chr17:43704505-43748512 (+)
BALB/cJ MGP_BALBcJ_G0023738
protein coding gene Chr17:43354704-43399748 (+)
C3H/HeJ MGP_C3HHeJ_G0023502
protein coding gene Chr17:44395366-44445709 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024181
protein coding gene Chr17:46450082-46495660 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021631
protein coding gene Chr17:40289551-40333678 (+)
CAST/EiJ MGP_CASTEiJ_G0022983
protein coding gene Chr17:44430045-44481794 (+)
CBA/J MGP_CBAJ_G0023478
protein coding gene Chr17:48086062-48132366 (+)
DBA/2J MGP_DBA2J_G0023604
protein coding gene Chr17:42265293-42309280 (+)
FVB/NJ MGP_FVBNJ_G0023571
protein coding gene Chr17:41827155-41873249 (+)
LP/J MGP_LPJ_G0023685
protein coding gene Chr17:45128650-45176455 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023600
protein coding gene Chr17:47729073-47777793 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024226
protein coding gene Chr17:44054156-44099442 (+)
PWK/PhJ MGP_PWKPhJ_G0022728
protein coding gene Chr17:41516646-41563454 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022543
protein coding gene Chr17:40918758-40966724 (+)
WSB/EiJ MGP_WSBEiJ_G0023048
protein coding gene Chr17:44571865-44619869 (+)



Homology
more
  • Human Ortholog
    PLA2G7, phospholipase A2 group VII
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLA2G7, phospholipase A2 group VII
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LDL-PLA2, LP-PLA2, PAFAD, PAFAH
  • Links
    NCBI Gene ID: 7941
    neXtProt AC: NX_Q13093
    UniProt: Q13093

  • Chr Location
    6p12.3; chr6:46700954-46735836 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PLA2G7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced early mortality in response to bacterial exposure, formula feeding and asphyxia, but survivors show a significantly higher incidence of necrotizing enterocolitis relative to wild-type controls.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023913 Ensembl Gene Model | MGI Sequence Detail 44104 C57BL/6J ±  kb
transcript ENSMUST00000024706 Ensembl | MGI Sequence Detail 2097 Not Applicable  
polypeptide ENSMUSP00000024706 Ensembl | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 13
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2147157
References
more
  • Summaries
    All 53
    Developmental Gene Expression 11
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:29539 Tjoelker LW, et al., Plasma platelet-activating factor acetylhydrolase is a secreted phospholipase A2 with a catalytic triad. J Biol Chem. 1995 Oct 27;270(43):25481-7
  • Latest
    J:248185 Pan X, et al., Myc cooperates with beta-catenin to drive gene expression in nephron progenitor cells. Development. 2017 Nov 15;144(22):4173-4182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory