About   Help   FAQ
Nrk Gene Detail
Summary
  • Symbol
    Nrk
  • Name
    Nik related kinase
  • Synonyms
    Nesk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351326
    NCBI Gene: 27206
  • Gene Overview
    MyGene.info: NRK
Location & Maps
more
  • Sequence Map
    ChrX:138914431-139010532 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96102 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NRK, Nik related kinase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NRK, Nik related kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NESK
  • Links
    NCBI Gene ID: 203447
    neXtProt AC: NX_Q7Z2Y5

  • Chr Location
    Xq22.3; chrX:105821856-105958612 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
    APF
Mice nullizygous for a knock-out allele exhibit partial lethality during delivery associated with enlarged placental and spongiotrophoblast layer and enduce dystocia in birthing dams.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018696 VEGA Gene Model | MGI Sequence Detail 96102 C57BL/6J ±  kb
transcript OTTMUST00000044980 VEGA | MGI Sequence Detail 8043 Not Applicable  
polypeptide OTTMUSP00000020210 VEGA | MGI Sequence Detail 1455 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    328 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 22
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142415, MGI:2147816, MGI:2147855, MGI:2147979, MGI:2148017
References
more
  • Summaries
    All 30
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:58547 Kanai-Azuma M, et al., Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev. 1999 Dec;89(1-2):155-9
  • Latest
    J:175907 Denda K, et al., Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor. J Biol Chem. 2011 Aug 19;286(33):28802-10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory