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Nrk
Gene Detail
Symbol

Name
ID
Nrk
Nik related kinase
MGI:1351326
Synonyms
Nesk
Feature Type
protein coding gene
Genetic Map
Chromosome X
61.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:138914431-139010532 bp, + strand
From VEGA annotation of GRCm38

  96102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: NRK
Gene Tree: Nrk

Human
homologs
NRK, Nik related kinase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 203447
neXtProt AC: NX_Q7Z2Y5

Human Synonyms: NESK

Human Chr (Location): Xq22.3; chrX:105821856-105958612 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice nullizygous for a knock-out allele exhibit partial lethality during delivery associated with enlarged placental and spongiotrophoblast layer and enduce dystocia in birthing dams.
 
Phenotype Images(3)
Interactions
Nrk interacts with 443 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process actin cytoskeleton reorganization, activation of JNKK activity, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (302)    Tissues (195)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 264
Northern blot 24
RT-PCR 14
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(22) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000018696 (Evidence)
Ensembl Gene Model ENSMUSG00000052854 (Evidence)
Entrez Gene 27206 (Evidence)
DFCI TC1581325, TC1618842, TC1598243
DoTS DT.94157022, DT.55236652, DT.87072308, DT.111027488
NIA Mouse Gene Index U043795
EC 2.7.11.1
Consensus CDS Project CCDS41143.1
International Mouse Phenotyping Consortium Status Nrk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018696 VEGA Gene Model | MGI Sequence Detail 96102 C57BL/6J ±  kb
transcript OTTMUST00000044980 VEGA | MGI Sequence Detail 8043 Not Applicable 
polypeptide OTTMUSP00000020210 VEGA | MGI Sequence Detail 1455 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(328 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron-like
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011430 Nik-related protein kinase
References
(Earliest) J:58547 Kanai-Azuma M, et al., Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev. 1999 Dec;89(1-2):155-9
(Latest) J:175907 Denda K, et al., Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor. J Biol Chem. 2011 Aug 19;286(33):28802-10
All references(33)
Other
accession IDs
MGI:2142415, MGI:2147816, MGI:2147855, MGI:2147979, MGI:2148017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory