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Nrk Gene Detail
Summary
  • Symbol
    Nrk
  • Name
    Nik related kinase
  • Synonyms
    Nesk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351326
    NCBI Gene: 27206
  • Gene Overview
    MyGene.info: NRK
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:138914430-139010532 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 61.15 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351326
protein coding gene ChrX:138914318-139010532 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036117
protein coding gene ChrX:136381922-136486165 (+)
A/J MGP_AJ_G0036096
protein coding gene ChrX:135774040-135871791 (+)
AKR/J MGP_AKRJ_G0036020
protein coding gene ChrX:140139605-140241287 (+)
BALB/cJ MGP_BALBcJ_G0036085
protein coding gene ChrX:134134220-134231108 (+)
C3H/HeJ MGP_C3HHeJ_G0035794
protein coding gene ChrX:136419454-136518676 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036610
protein coding gene ChrX:140420125-140518930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033435
protein coding gene ChrX:127572328-127672086 (+)
CAST/EiJ MGP_CASTEiJ_G0035085
protein coding gene ChrX:117202840-117321463 (+)
CBA/J MGP_CBAJ_G0035771
protein coding gene ChrX:144666983-144769254 (+)
DBA/2J MGP_DBA2J_G0035928
protein coding gene ChrX:134984532-135083789 (+)
FVB/NJ MGP_FVBNJ_G0035862
protein coding gene ChrX:134216639-134311731 (+)
LP/J MGP_LPJ_G0036020
protein coding gene ChrX:137340069-137445658 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035899
protein coding gene ChrX:152154369-152292294 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036646
protein coding gene ChrX:135725649-135822262 (+)
PWK/PhJ MGP_PWKPhJ_G0034778
protein coding gene ChrX:114176306-114274109 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034605
protein coding gene ChrX:117769523-117866685 (+)
WSB/EiJ MGP_WSBEiJ_G0035220
protein coding gene ChrX:134023938-134123922 (+)



Homology
more
  • Human Ortholog
    NRK, Nik related kinase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NRK, Nik related kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NESK
  • Links
    NCBI Gene ID: 203447
    neXtProt AC: NX_Q7Z2Y5
    UniProt: Q7Z2Y5

  • Chr Location
    Xq22.3; chrX:105821944-105958610 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    3 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice nullizygous for a knock-out allele exhibit partial lethality during delivery associated with enlarged placental and spongiotrophoblast layer and enduce dystocia in birthing dams.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052854 Ensembl Gene Model | MGI Sequence Detail 96103 C57BL/6J ±  kb
    transcript ENSMUST00000064937 Ensembl | MGI Sequence Detail 6604 Not Applicable  
    polypeptide ENSMUSP00000063397 Ensembl | MGI Sequence Detail 1455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 23
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142415, MGI:2147816, MGI:2147855, MGI:2147979, MGI:2148017
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:58547 Kanai-Azuma M, et al., Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev. 1999 Dec;89(1-2):155-9
    • Latest
      J:245779 Morioka Y, et al., Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation. PLoS One. 2017;12(2):e0171503

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory