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Nrk
Gene Detail
 Symbol
Name
ID
Nrk
Nik related kinase
MGI:1351326
Synonyms Nesk
Feature Type protein coding gene
Genetic Map
Chromosome X
61.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:138914431-139010532 bp, + strand
From VEGA annotation of GRCm38

  96102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Nrk

Human
homologs
Human Homolog NRK, Nik related kinase
NCBI Gene ID 203447
neXtProt AC  NX_Q7Z2Y5
Human Synonyms  NESK
Human Chr (Location)  Xq22.3; chrX:105822543-105958610 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice nullizygous for a knock-out allele exhibit partial lethality during delivery associated with enlarged placental and spongiotrophoblast layer and enduce dystocia in birthing dams.
 
Phenotype Images(3)
Interactions
Nrk interacts with 444 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process activation of JNKK activity, negative regulation of cell proliferation, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (302)    Tissues (195)    Images (49)
Theiler Stages: 10, 11, 13, 15, 17, 18, 19, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 264
Northern blot 24
RT-PCR 14
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(22) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000018696 (Evidence)
Ensembl Gene ModelENSMUSG00000052854 (Evidence)
Entrez Gene27206 (Evidence)
DFCITC1581325, TC1598243, TC1618842
DoTSDT.111027488, DT.55236652, DT.87072308, DT.94157022
NIA Mouse Gene IndexU043795
EC2.7.11.1
Consensus CDS ProjectCCDS41143.1
International Mouse Knockout Project StatusNrk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018696 VEGA Gene Model | MGI Sequence Detail 96102 C57BL/6J ±  kb
transcript OTTMUST00000044980 VEGA | MGI Sequence Detail 8043 Not Applicable 
polypeptide OTTMUSP00000020210 VEGA | MGI Sequence Detail 1455 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(328 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron-like
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011430 Nik-related protein kinase
References (Earliest) J:58547 Kanai-Azuma M, et al., Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev. 1999 Dec;89(1-2):155-9
(Latest) J:175907 Denda K, et al., Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor. J Biol Chem. 2011 Aug 19;286(33):28802-10
All references(34)
Other
accession IDs
MGI:2142415, MGI:2147816, MGI:2147855, MGI:2147979, MGI:2148017

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory