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Slamf1 Gene Detail
Summary
  • Symbol
    Slamf1
  • Name
    signaling lymphocytic activation molecule family member 1
  • Synonyms
    CD150, CDw150, ESTM51, IPO-3, Slam
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351314
    NCBI Gene: 27218
  • Gene Overview
    MyGene.info: SLAMF1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171767132-171801184 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351314
protein coding gene Chr1:171767127-171801184 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016770
protein coding gene Chr1:177605753-177639549 (+)
A/J MGP_AJ_G0016749
protein coding gene Chr1:170342642-170379127 (+)
AKR/J MGP_AKRJ_G0016715
protein coding gene Chr1:175485358-175520389 (+)
BALB/cJ MGP_BALBcJ_G0016710
protein coding gene Chr1:170886715-170927486 (+)
C3H/HeJ MGP_C3HHeJ_G0016534
protein coding gene Chr1:176050696-176098292 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017172
protein coding gene Chr1:183485106-183525398 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014879
protein coding gene Chr1:162058879-162094178 (+)
CAST/EiJ MGP_CASTEiJ_G0016115
protein coding gene Chr1:175413692-175450833 (+)
CBA/J MGP_CBAJ_G0016508
protein coding gene Chr1:190046928-190083186 (+)
DBA/2J MGP_DBA2J_G0016615
protein coding gene Chr1:169277971-169316515 (+)
FVB/NJ MGP_FVBNJ_G0016612
protein coding gene Chr1:167532619-167566261 (+)
LP/J MGP_LPJ_G0016686
protein coding gene Chr1:178685325-178722082 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016639
protein coding gene Chr1:197310877-197345854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017208
protein coding gene Chr1:175344764-175384039 (+)
PWK/PhJ MGP_PWKPhJ_G0015900
protein coding gene Chr1:168656249-168690756 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016176
protein coding gene Chr1:175516076-175552201 (+)



Homology
more
  • Human Ortholog
    SLAMF1, signaling lymphocytic activation molecule family member 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SLAMF1, signaling lymphocytic activation molecule family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD150, CDw150, SLAM
  • Links
    NCBI Gene ID: 6504
    neXtProt AC: NX_Q13291
    UniProt: Q13291

  • Chr Location
    1q23.3; chr1:160608103-160647537 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display impaired T cell and macrophage cytokine production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27218 NCBI Gene Model | MGI Sequence Detail 34053 C57BL/6J ±  kb
transcript NM_013730 RefSeq | MGI Sequence Detail 2688 C57BL/6  
polypeptide Q9QUM4 UniProt | EBI | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 4
    cDNA 25
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1334421
References
more
  • Summaries
    All 79
    Developmental Gene Expression 4
    Gene Ontology 17
    Phenotypes 27
  • Earliest
    J:227465 Aversa G, et al., Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production. J Immunol. 1997 May 1;158(9):4036-44
  • Latest
    J:260485 Yurchenko M, et al., SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018 Apr 2;217(4):1411-1429

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory