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Tlx2
Gene Detail
 Symbol
Name
ID
Tlx2
T cell leukemia, homeobox 2
MGI:1350935
Synonyms Enx, Hox11l1, Hox11L.1, NCX, Ncx1, Tlx1l1
Feature Type protein coding gene
Genetic Map
Chromosome 6
35.94 cM, cytoband C3-D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:83068324-83070225 bp, - strand
From VEGA annotation of GRCm38

  1902 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Tlx2

Human
homologs
Human Homolog TLX2, T-cell leukemia homeobox 2
NCBI Gene ID 3196
neXtProt AC  NX_O43763
Human Synonyms  HOX11L1, NCX
Human Chr (Location)  2p13.1; chr2:74514469-74517148 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for two targeted null mutations exhibit megacolon with hyperinnervated enteric ganglia which undergo neuronal degeneration. Homozygotes for a third null mutation die in utero with defects in formation of the primitive streak and mesoderm.
 
Human Diseases Modeled Using Mouse Tlx2 (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Tlx2 interacts with 72 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process enteric nervous system development, mesoderm formation, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (237)    Tissues (164)    Images (43)
Theiler Stages: 8, 10, 11, 12, 14, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 237
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(5) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037556 (Evidence)
Ensembl Gene ModelENSMUSG00000068327 (Evidence)
Entrez Gene21909 (Evidence)
UniGene37
DFCITC1595835, TC1691599
DoTSDT.40158379, DT.91338288
NIA Mouse Gene IndexU027518
Consensus CDS ProjectCCDS20269.1
International Mouse Knockout Project StatusTlx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037556 VEGA Gene Model | MGI Sequence Detail 1902 C57BL/6J ±  kb
transcript OTTMUST00000096813 VEGA | MGI Sequence Detail 1086 Not Applicable 
polypeptide OTTMUSP00000054132 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000016384 T-cell leukemia homeobox protein 2
References (Earliest) J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(50)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15138, MGD-MRK-26032, MGD-MRK-26033, MGD-MRK-27029, MGI:104666, MGI:98770

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory