About   Help   FAQ
Tlx2
Gene Detail
Symbol

Name
ID
Tlx2
T cell leukemia, homeobox 2
MGI:1350935
Synonyms
Enx, Hox11l1, Hox11L.1, NCX, Ncx1, Tlx1l1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM, cytoband C3-D1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr6:83068324-83070225 bp, - strand
From VEGA annotation of GRCm38

  1902 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TLX2
Gene Tree: Tlx2

Human
homologs
TLX2, T-cell leukemia homeobox 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3196
neXtProt AC: NX_O43763

Human Synonyms: HOX11L1, NCX

Human Chr (Location): 2p13.1; chr2:74514469-74517148 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Genomic Mutations involving Tlx2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for two targeted null mutations exhibit megacolon with hyperinnervated enteric ganglia which undergo neuronal degeneration. Homozygotes for a third null mutation die in utero with defects in formation of the primitive streak and mesoderm.
 
Human Diseases Modeled in Mice Using Tlx2 (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Tlx2 interacts with 72 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process enteric nervous system development, mesoderm formation, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (237)    Tissues (164)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 237
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN tlx2    NEW 
Molecular
reagents
All nucleic(18) Genomic(5) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037556 (Evidence)
Ensembl Gene Model ENSMUSG00000068327 (Evidence)
Entrez Gene 21909 (Evidence)
UniGene 37
DFCI TC1595835, TC1691599
DoTS DT.40158379, DT.91338288
NIA Mouse Gene Index U027518
Consensus CDS Project CCDS20269.1
International Mouse Phenotyping Consortium Status Tlx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037556 VEGA Gene Model | MGI Sequence Detail 1902 C57BL/6J ±  kb
transcript OTTMUST00000096813 VEGA | MGI Sequence Detail 1086 Not Applicable 
polypeptide OTTMUSP00000054132 VEGA | MGI Sequence Detail 284 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(11 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000016384 T-cell leukemia homeobox protein 2
References
(Earliest) J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(49)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-15138, MGD-MRK-26032, MGD-MRK-26033, MGD-MRK-27029, MGI:104666, MGI:98770

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory