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Tlx2 Gene Detail
Summary
  • Symbol
    Tlx2
  • Name
    T cell leukemia, homeobox 2
  • Synonyms
    Enx, Hox11l1, Hox11L.1, NCX, Ncx1, Tlx1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350935
    NCBI Gene: 21909
  • Gene Overview
    MyGene.info: TLX2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83068325-83070225 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM, cytoband C3-D1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350935
protein coding gene Chr6:83068324-83070293 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030914
protein coding gene Chr6:84071842-84073811 (-)
A/J MGP_AJ_G0030883
protein coding gene Chr6:80859252-80861221 (-)
AKR/J MGP_AKRJ_G0030811
protein coding gene Chr6:83188147-83190116 (-)
BALB/cJ MGP_BALBcJ_G0030893
protein coding gene Chr6:80871924-80873893 (-)
C3H/HeJ MGP_C3HHeJ_G0030817
protein coding gene Chr6:101191934-101193903 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031353
protein coding gene Chr6:86351365-86353334 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028539
protein coding gene Chr6:79217507-79219455 (-)
CAST/EiJ MGP_CASTEiJ_G0030002
protein coding gene Chr6:83188567-83190529 (-)
CBA/J MGP_CBAJ_G0030580
protein coding gene Chr6:89763657-89765626 (-)
DBA/2J MGP_DBA2J_G0030733
protein coding gene Chr6:80179021-80180990 (-)
FVB/NJ MGP_FVBNJ_G0030686
protein coding gene Chr6:79385826-79387795 (-)
LP/J MGP_LPJ_G0030812
protein coding gene Chr6:84065916-84067885 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030722
protein coding gene Chr6:94068988-94070957 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031377
protein coding gene Chr6:83002119-83004075 (-)
PWK/PhJ MGP_PWKPhJ_G0029717
protein coding gene Chr6:79071527-79073482 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029545
protein coding gene Chr6:81847478-81849440 (-)
WSB/EiJ MGP_WSBEiJ_G0030083
protein coding gene Chr6:83440478-83442447 (-)



Homology
more
  • Human Ortholog
    TLX2, T cell leukemia homeobox 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TLX2, T cell leukemia homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HOX11L1, NCX
  • Links
    NCBI Gene ID: 3196
    neXtProt AC: NX_O43763
    UniProt: O43763

  • Chr Location
    2p13.1; chr2:74514469-74517148 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tlx2 mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for two targeted null mutations exhibit megacolon with hyperinnervated enteric ganglia which undergo neuronal degeneration. Homozygotes for a third null mutation die in utero with defects in formation of the primitive streak and mesoderm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21909 NCBI Gene Model | MGI Sequence Detail 1901 C57BL/6J ±  kb
    transcript NM_009392 RefSeq | MGI Sequence Detail 1434 C57BL/6  
    polypeptide Q61663 UniProt | EBI | MGI Sequence Detail 284 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 5
      cDNA 13
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15138, MGD-MRK-26032, MGD-MRK-26033, MGD-MRK-27029, MGI:104666, MGI:98770
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory