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Tlx2 Gene Detail
Summary
  • Symbol
    Tlx2
  • Name
    T cell leukemia, homeobox 2
  • Synonyms
    Enx, Hox11l1, Hox11L.1, NCX, Ncx1, Tlx1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350935
    NCBI Gene: 21909
  • Gene Overview
    MyGene.info: TLX2
Location & Maps
more
  • Sequence Map
    Chr6:83068324-83070293 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1970 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TLX2, T-cell leukemia homeobox 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TLX2, T-cell leukemia homeobox 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HOX11L1, NCX
  • Links
    NCBI Gene ID: 3196
    neXtProt AC: NX_O43763

  • Chr Location
    2p13.1; chr2:74514469-74517148 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Tlx2 mouse models

Human Disease Mouse Models
       Neuronal Intestinal Dysplasia, Type B   OMIM: 601223 View 2 models
Visceral Neuropathy, Familial, Autosomal Recessive   OMIM: 243180 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Tlx2
  • Incidental Mutations
Homozygotes for two targeted null mutations exhibit megacolon with hyperinnervated enteric ganglia which undergo neuronal degeneration. Homozygotes for a third null mutation die in utero with defects in formation of the primitive streak and mesoderm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037556 VEGA Gene Model | MGI Sequence Detail 1970 C57BL/6J ±  kb
transcript OTTMUST00000096813 VEGA | MGI Sequence Detail 1236 Not Applicable  
polypeptide OTTMUSP00000054132 VEGA | MGI Sequence Detail 284 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    11 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 5
    cDNA 12
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-15138, MGD-MRK-26032, MGD-MRK-26033, MGD-MRK-27029, MGI:104666, MGI:98770
References
more
  • Summaries
    All 46
    Developmental Gene Expression 11
    Diseases 2
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:12674 Kennedy MA, et al., HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8900-4
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory