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Ncoa4 Gene Detail
Summary
  • Symbol
    Ncoa4
  • Name
    nuclear receptor coactivator 4
  • Synonyms
    1110034E15Rik, 4432406M01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350932
    NCBI Gene: 27057
  • Gene Overview
    MyGene.info: NCOA4
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:32159887-32179855 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.40 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350932
protein coding gene Chr14:32159865-32179855 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021139
protein coding gene Chr14:25392831-25413029 (+)
A/J MGP_AJ_G0021087
protein coding gene Chr14:24422969-24442960 (+)
AKR/J MGP_AKRJ_G0021064
protein coding gene Chr14:25569574-25589561 (+)
BALB/cJ MGP_BALBcJ_G0021091
protein coding gene Chr14:24598823-24620760 (+)
C3H/HeJ MGP_C3HHeJ_G0020874
protein coding gene Chr14:25446065-25466050 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021523
protein coding gene Chr14:26402974-26429397 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019086
protein coding gene Chr14:24488002-24508296 (+)
CAST/EiJ MGP_CASTEiJ_G0020399
protein coding gene Chr14:25237030-25257003 (+)
CBA/J MGP_CBAJ_G0020841
protein coding gene Chr14:27393099-27413162 (+)
DBA/2J MGP_DBA2J_G0020963
protein coding gene Chr14:24455978-24475998 (+)
FVB/NJ MGP_FVBNJ_G0020947
protein coding gene Chr14:24415665-24438127 (+)
LP/J MGP_LPJ_G0021032
protein coding gene Chr14:25715350-25736154 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020973
protein coding gene Chr14:26631430-26651538 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021556
protein coding gene Chr14:25343975-25363967 (+)
PWK/PhJ MGP_PWKPhJ_G0020147
protein coding gene Chr14:23926488-23947232 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019971
protein coding gene Chr14:24950538-24970437 (+)
WSB/EiJ MGP_WSBEiJ_G0020454
protein coding gene Chr14:25405941-25425981 (+)



Homology
more
  • Human Ortholog
    NCOA4, nuclear receptor coactivator 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCOA4, nuclear receptor coactivator 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ARA70, ELE1, PTC3, RFG
  • Links
    NCBI Gene ID: 8031
    neXtProt AC: NX_Q13772
    UniProt: Q13772

  • Chr Location
    10q11.22; chr10:46005088-46030714 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38052
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NCOA4
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mouse embryonic fibroblasts isolated from homozygous null mice exhibit abnormal DNA replication, decreased fibroblast proliferation, and early cellular replicative senescence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 27057 NCBI Gene Model | MGI Sequence Detail 19969 C57BL/6J ±  kb
transcript NM_001033988 RefSeq | MGI Sequence Detail 4043 C57BL/6  
polypeptide NP_062718 RefSeq | MGI Sequence Detail 625 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    17 Sequences
  • InterPro Domains
    IPR022174 Nuclear coactivator
    IPR039947 Nuclear receptor coactivator 4
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1913942, MGI:1915907, MGI:2145605
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:51366 Powell DJ Jr, et al., The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Res. 1998 Dec 1;58(23):5523-8
  • Latest
    J:253625 Gao X, et al., Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10107-10112

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/27/2018
MGI 6.13
The Jackson Laboratory