Aoah
Gene Detail

Symbol Name ID

Aoah acyloxyacyl hydrolase MGI:1350928

Synonyms

4930433E13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 13

7.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:20794119-21024252 bp, + strand From NCBI annotation of GRCm38   230134 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: acyloxyacyl hydrolase
Gene Tree: Aoah

Human homologs

Human Homolog		AOAH, acyloxyacyl hydrolase (neutrophil)
NCBI Gene ID		313
neXtProt AC		NX_P28039
Human Chr (Location)		7p14-p12; chr7:36552549-36764154 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(25) : Targeted(2) Gene trapped(23)
 

Homozygous null mice have a reduced ability to deacylate bacterial lipopolysaccharides.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	lipid metabolic process, lipopolysaccharide metabolic process, ...
Component	extracellular region
Function	acyloxyacyl hydrolase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 24

Assay Type	Results
RNA in situ	1

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(21)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000021322 (Evidence)
Entrez Gene	27052 (Evidence)
UniGene	314046
DFCI	TC1583135, TC1595937
DoTS	DT.101340905, DT.101399752, DT.55168601, DT.91308816, DT.94129408
NIA Mouse Gene Index	U014590, U375713
EC	3.1.1.77
Consensus CDS Project	CCDS26266.1
International Mouse Knockout Project Status	Aoah

Sequences

Length	Strain/Species
genomic	27052	NCBI Gene Model | MGI Sequence Detail	230134	C57BL/6J
transcript	NM_012054	RefSeq | MGI Sequence Detail	2915	C57BL/6
polypeptide	O35298	UniProt | EBI | MGI Sequence Detail	574	Not Applicable

All sequences(36) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(1367 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013830	Esterase, SGNH hydrolase-type
InterPro	IPR013831	Esterase, SGNH hydrolase-type, subgroup
InterPro	IPR001087	Lipase, GDSL
InterPro	IPR008139	Saposin B
InterPro	IPR011001	Saposin-like
InterPro	IPR008138	Saposin-like type B, 2
Protein Ontology	PR:000004085	acyloxyacyl hydrolase

Graphical View of Protein Domain Structure

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:179236 Lu M, et al., The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo. J Immunol. 2011 Sep 15;187(6):3314-20
All references(37)

Other accession IDs

MGI:1921929