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Aoah
Gene Detail
 Symbol
Name
ID
Aoah
acyloxyacyl hydrolase
MGI:1350928
Synonyms 4930433E13Rik
Feature Type protein coding gene
Genetic Map
Chromosome 13
7.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:20794119-21024252 bp, + strand
From NCBI annotation of GRCm38

  230134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1238  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: acyloxyacyl hydrolase
Gene Tree: Aoah

Human
homologs
Human Homolog AOAH, acyloxyacyl hydrolase (neutrophil)
NCBI Gene ID 313
neXtProt AC  NX_P28039
Human Chr (Location)  7p14-p12; chr7:36512941-36724549 (-)  GRCh38
Alleles
and
phenotypes
All alleles(25) : Gene trapped(23) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have a reduced ability to deacylate bacterial lipopolysaccharides.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process lipid metabolic process, lipopolysaccharide metabolic process, ...
Component extracellular region
Function acyloxyacyl hydrolase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 24
Assay TypeResults
RNA in situ 1
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(21)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000021322 (Evidence)
Entrez Gene27052 (Evidence)
UniGene314046
DFCITC1583135, TC1595937
DoTSDT.101340905, DT.101399752, DT.55168601, DT.91308816, DT.94129408
NIA Mouse Gene IndexU014590, U375713
EC3.1.1.77
Consensus CDS ProjectCCDS26266.1
International Mouse Knockout Project StatusAoah
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 27052 NCBI Gene Model | MGI Sequence Detail 230134 C57BL/6J ±  kb
transcript NM_012054 RefSeq | MGI Sequence Detail 2923 C57BL/6 
polypeptide O35298 UniProt | EBI | MGI Sequence Detail 574 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(12) UniProt(7)
Polymorphisms SNPs within 2kb(2314 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2334)
Protein-related
information
ResourceIDDescription
InterPro IPR001087 Lipase, GDSL
InterPro IPR008139 Saposin B
InterPro IPR011001 Saposin-like
InterPro IPR008138 Saposin-like type B, 2
InterPro IPR013831 SGNH hydrolase-type esterase domain
Protein Ontology PR:000004085 acyloxyacyl hydrolase
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:206287 Janelsins BM, et al., Altered inactivation of commensal LPS due to acyloxyacyl hydrolase deficiency in colonic dendritic cells impairs mucosal Th17 immunity. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):373-8
All references(38)
Other
accession IDs
MGI:1921929

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory