Etv3 MGI Mouse Gene Detail - MGI:1350926

Symbol

Etv3
Name

ets variant 3
Synonyms

ETS-domain transcriptional repressor, METS, Pe1

Feature Type

protein coding gene
IDs

MGI:1350926
NCBI Gene: 27049
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr3:87432884-87447465 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.19 cM
Mapping Data

1 experiment

SNPs within 2kb

77 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1350926	protein coding gene	Chr3:87432714-87447465 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027364	protein coding gene	Chr3:87626760-87641481 (+)
A/J	MGP_AJ_G0027328	protein coding gene	Chr3:84666725-84681452 (+)
AKR/J	MGP_AKRJ_G0027294	protein coding gene	Chr3:86703566-86718248 (+)
BALB/cJ	MGP_BALBcJ_G0027337	protein coding gene	Chr3:84744148-84758848 (+)
C3H/HeJ	MGP_C3HHeJ_G0027080	protein coding gene	Chr3:87003751-87018471 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027783	protein coding gene	Chr3:90856850-90871599 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025136	protein coding gene	Chr3:80284727-80299305 (+)
CAST/EiJ	MGP_CASTEiJ_G0026527	protein coding gene	Chr3:87218498-87233212 (+)
CBA/J	MGP_CBAJ_G0027055	protein coding gene	Chr3:93927039-93941759 (+)
DBA/2J	MGP_DBA2J_G0027191	protein coding gene	Chr3:84150056-84164741 (+)
FVB/NJ	MGP_FVBNJ_G0027160	protein coding gene	Chr3:82429041-82443761 (+)
LP/J	MGP_LPJ_G0027299	protein coding gene	Chr3:88579370-88594092 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027179	protein coding gene	Chr3:100192785-100208291 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027841	protein coding gene	Chr3:86479452-86494170 (+)
PWK/PhJ	MGP_PWKPhJ_G0026260	protein coding gene	Chr3:83948073-83962786 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026077	protein coding gene	Chr3:85667177-85684112 (+)
WSB/EiJ	MGP_WSBEiJ_G0026606	protein coding gene	Chr3:86844347-86859069 (+)

Human Ortholog

ETV3, ETS variant transcription factor 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ETV3, ETS variant transcription factor 3
Synonyms

METS, PE1, PE-1
Links

HGNC:3492

NCBI Gene ID: 2117

neXtProt AC: NX_P41162

UniProt: P41162
Chr Location

1q23.1; chr1:157121191-157138591 (-) GRCh38.p7

Alliance of Genome Resources

Etv3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ETV3
Gene Tree

Etv3

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References

1 with disease annotations

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Etv3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

16 strains or lines available

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All GO Annotations

21
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

92
cDNA Data

17
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase etv3

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Etv3 interacts with 390 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

61
RefSeq

10
UniProt

4
CCDS

CCDS17453.1

Ensembl

ENSMUSG00000003382 (Evidence)
NCBI Gene

27049

Representative Sequences				Length	Strain/Species	Flank
	genomic	27049	NCBI Gene Model \| MGI Sequence Detail	14582	C57BL/6J	± kb

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UniProt

4 Sequences
Protein Ontology

PR:000007225 ETS translocation variant 3

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR032929 ETS translocation variant 3

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 20

cDNA 17

Primer pair 1

Other 2

Microarray probesets 6

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MGI:2139692

Summaries

All 46

Developmental Gene Expression 9

Diseases 1

Gene Ontology 5

Phenotypes 10
Earliest

J:17414 Klemsz M, et al., PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. Genomics. 1994 Mar 15;20(2):291-4
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Etv3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29811	Chr3:87432879-87432950 (+)	31 bp
Tssr29812	Chr3:87432953-87432974 (+)	80 bp
Tssr29813	Chr3:87433712-87433739 (+)	842 bp
Tssr29814	Chr3:87433816-87433839 (+)	944 bp
Tssr29815	Chr3:87434535-87434546 (+)	1,657 bp
Tssr29816	Chr3:87434606-87434613 (+)	1,726 bp
Tssr29817	Chr3:87434625-87434634 (+)	1,746 bp
Tssr29818	Chr3:87434677-87434745 (+)	1,827 bp
Tssr29819	Chr3:87442957-87442970 (+)	10,080 bp
Tssr29820	Chr3:87443025-87443037 (+)	10,147 bp
Tssr29821	Chr3:87443064-87443079 (+)	10,188 bp
Tssr29822	Chr3:87443182-87443199 (+)	10,307 bp
Tssr29823	Chr3:87443363-87443380 (+)	10,488 bp
Tssr29824	Chr3:87443503-87443517 (+)	10,626 bp
Tssr29825	Chr3:87446640-87446651 (+)	13,762 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/17/2022 MGI 6.19