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Sec23b Gene Detail
Summary
  • Symbol
    Sec23b
  • Name
    SEC23 homolog B, COPII coat complex component
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350925
    NCBI Gene: 27054
  • Gene Overview
    MyGene.info: SEC23B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:144556229-144590749 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 71.02 cM, cytoband H1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350925
protein coding gene Chr2:144556229-144590753 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026589
protein coding gene Chr2:148664377-148700015 (+)
A/J MGP_AJ_G0026553
protein coding gene Chr2:142644090-142679095 (+)
AKR/J MGP_AKRJ_G0026527
protein coding gene Chr2:146736146-146772301 (+)
BALB/cJ MGP_BALBcJ_G0026565
protein coding gene Chr2:143080912-143115968 (+)
C3H/HeJ MGP_C3HHeJ_G0026308
protein coding gene Chr2:147280071-147318660 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027010
protein coding gene Chr2:153110282-153146251 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024387
protein coding gene Chr2:136817533-136851904 (+)
CAST/EiJ MGP_CASTEiJ_G0025769
protein coding gene Chr2:147619629-147654952 (+)
CBA/J MGP_CBAJ_G0026288
protein coding gene Chr2:158699124-158737793 (+)
DBA/2J MGP_DBA2J_G0026422
protein coding gene Chr2:141923781-141958276 (+)
FVB/NJ MGP_FVBNJ_G0026386
protein coding gene Chr2:140504196-140538338 (+)
LP/J MGP_LPJ_G0026526
protein coding gene Chr2:148810079-148846820 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026406
protein coding gene Chr2:162889553-162930477 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027065
protein coding gene Chr2:146727564-146763150 (+)
PWK/PhJ MGP_PWKPhJ_G0025505
protein coding gene Chr2:141586623-141621450 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025306
protein coding gene Chr2:145775553-145810025 (+)
WSB/EiJ MGP_WSBEiJ_G0025842
protein coding gene Chr2:147740633-147776282 (+)



Homology
more
  • Human Ortholog
    SEC23B, Sec23 homolog B, coat complex II component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC23B, Sec23 homolog B, coat complex II component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDAII, CDA-II, CDAN2, CWS7, HEMPAS, hSec23B
  • Links
    NCBI Gene ID: 10483
    neXtProt AC: NX_Q15437
    UniProt: Q15437

  • Chr Location
    20p11.23; chr20:18507544-18561415 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SEC23B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 4 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    8 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display complete neonatal lethality, fail to suckle, and show degeneration of the secretory tissues in the pancreas, salivary gland, and gastric glands.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027429 Ensembl Gene Model | MGI Sequence Detail 34521 C57BL/6J ±  kb
transcript ENSMUST00000028916 Ensembl | MGI Sequence Detail 2779 Not Applicable  
polypeptide ENSMUSP00000028916 Ensembl | MGI Sequence Detail 767 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:236027 Khoriaty R, et al., Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice. Sci Rep. 2016 Jun 14;6:27802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory