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Sec23b
Gene Detail
Symbol

Name
ID
Sec23b
SEC23B (S. cerevisiae)
MGI:1350925
Feature Type
protein coding gene
Genetic Map
Chromosome 2
71.02 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:144556229-144590749 bp, + strand
From VEGA annotation of GRCm38

  34521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74571  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: SEC23 protein
Gene Tree: Sec23b

Human
homologs
Human Homolog SEC23B, Sec23 homolog B (S. cerevisiae)
NCBI Gene ID 10483
neXtProt AC  NX_Q15437
Human Synonyms  CDAII, CDA-II, CDAN2, HEMPAS
Human Chr (Location)  20p11.23; chr20:18507544-18561415 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SEC23B
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(19) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display complete neonatal lethality, fail to suckle, and show degeneration of the secretory tissues in the pancreas, salivary gland, and gastric glands.
 
Phenotype Images(8)
Interactions
Sec23b interacts with 110 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process ER to Golgi vesicle-mediated transport, intracellular protein transport, ...
Component COPII vesicle coat, endomembrane system, ...
Function protein binding, zinc ion binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003918 (Evidence)
Ensembl Gene ModelENSMUSG00000027429 (Evidence)
Entrez Gene27054 (Evidence)
DFCITC1612425, TC1680389, TC1611212, TC1572102, TC1677360, TC1753654
DoTSDT.101377884, DT.494192, DT.101377887, DT.55243752, DT.91307865, DT.94134950, DT.91342071, DT.94352469
NIA Mouse Gene IndexU002574
Consensus CDS ProjectCCDS16822.1
International Mouse Knockout Project StatusSec23b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003918 VEGA Gene Model | MGI Sequence Detail 34521 C57BL/6J ±  kb
transcript OTTMUST00000008693 VEGA | MGI Sequence Detail 2779 Not Applicable 
polypeptide OTTMUSP00000004231 VEGA | MGI Sequence Detail 767 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(10) UniProt(21)
Polymorphisms
SNPs within 2kb(628 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007123 Gelsolin domain
InterPro IPR012990 Sec23/Sec24 beta-sandwich
InterPro IPR006900 Sec23/Sec24, helical domain
InterPro IPR006896 Sec23/Sec24, trunk domain
InterPro IPR002035 von Willebrand factor, type A
InterPro IPR006895 Zinc finger, Sec23/Sec24-type
Protein Ontology PR:000014587 protein transport protein Sec23B
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:213188 Khoriaty R, et al., Absence of a Red Blood Cell Phenotype in Mice with Hematopoietic Deficiency of SEC23B. Mol Cell Biol. 2014 Oct 1;34(19):3721-34
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory