Sec23b
Gene Detail

Symbol Name ID

Sec23b SEC23B (S. cerevisiae) MGI:1350925

Feature Type

protein coding gene

Genetic Map

Chromosome 2

71.02 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:144556229-144590749 bp, + strand From VEGA annotation of GRCm38   34521 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74571  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: SEC23 protein
Gene Tree: Sec23b

Human homologs

Human Homolog		SEC23B, Sec23 homolog B (S. cerevisiae)
NCBI Gene ID		10483
neXtProt AC		NX_Q15437
Human Synonyms		CDAII, CDA-II, CDAN2, HEMPAS
Human Chr (Location)		20p11.23; chr20:18488188-18542059 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SEC23B

Alleles and phenotypes

All alleles(22) : Targeted(3) Gene trapped(19)
 

Mice homozygous for a null mutation display complete neonatal lethality, fail to suckle, and show degeneration of the secretory tissues in the pancreas, salivary gland, and gastric glands.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	ER to Golgi vesicle-mediated transport, intracellular protein transport, ...
Component	COPII vesicle coat, endoplasmic reticulum, ...
Function	zinc ion binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(180)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(180) cDNA(180)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000003918 (Evidence)
Ensembl Gene Model	ENSMUSG00000027429 (Evidence)
Entrez Gene	27054 (Evidence)
UniGene	248492
DFCI	TC1572102, TC1611212, TC1612425, TC1677360, TC1680389, TC1753654
DoTS	DT.101377884, DT.101377887, DT.494192, DT.55243752, DT.91307865, DT.91342071, DT.94134950, DT.94352469
NIA Mouse Gene Index	U002574
Consensus CDS Project	CCDS16822.1
International Mouse Knockout Project Status	Sec23b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003918	VEGA Gene Model | MGI Sequence Detail	34521	C57BL/6J
transcript	OTTMUST00000008693	VEGA | MGI Sequence Detail	2779	Not Applicable
polypeptide	OTTMUSP00000004231	VEGA | MGI Sequence Detail	767	Not Applicable

All sequences(99) RefSeq(9) UniProt(11)

Polymorphisms

SNPs(251 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007123	Gelsolin domain
InterPro	IPR012990	Sec23/Sec24 beta-sandwich
InterPro	IPR006900	Sec23/Sec24, helical domain
InterPro	IPR006896	Sec23/Sec24, trunk domain
InterPro	IPR002035	von Willebrand factor, type A
InterPro	IPR006895	Zinc finger, Sec23/Sec24-type
Protein Ontology	PR:000014587	protein transport protein Sec23B

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:186391 Tao J, et al., SEC23B is required for the maintenance of murine professional secretory tissues. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):E2001-9
All references(34)