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Sec23b Gene Detail
Summary
  • Symbol
    Sec23b
  • Name
    SEC23 homolog B, COPII coat complex component
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350925
    NCBI Gene: 27054
  • Gene Overview
    MyGene.info: SEC23B
Location & Maps
more
  • Sequence Map
    Chr2:144556229-144590749 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34521 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 71.02 cM, cytoband H1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SEC23B, Sec23 homolog B, coat complex II component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC23B, Sec23 homolog B, coat complex II component
    Orthology source: HomoloGene
  • Synonyms
    CDAII, CDA-II, CDAN2, CWS7, HEMPAS
  • Links
    NCBI Gene ID: 10483
    neXtProt AC: NX_Q15437

  • Chr Location
    20p11.23; chr20:18507544-18561415 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human SEC23B associations

Human Disease Mouse Models
       Anemia, Congenital Dyserythropoietic, Type II; CDAN2   OMIM: 224100
Cowden Syndrome 7; CWS7   OMIM: 616858
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 6 genetic backgrounds
    8 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    26
  • Chemically induced (other)
    1
  • Gene trapped
    19
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Sec23b
  • Incidental Mutations
Mice homozygous for a null mutation display complete neonatal lethality, fail to suckle, and show degeneration of the secretory tissues in the pancreas, salivary gland, and gastric glands.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003918 VEGA Gene Model | MGI Sequence Detail 34521 C57BL/6J ±  kb
transcript OTTMUST00000008693 VEGA | MGI Sequence Detail 2779 Not Applicable  
polypeptide OTTMUSP00000004231 VEGA | MGI Sequence Detail 767 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    623 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:213188 Khoriaty R, et al., Absence of a Red Blood Cell Phenotype in Mice with Hematopoietic Deficiency of SEC23B. Mol Cell Biol. 2014 Oct 1;34(19):3721-34

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory