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Nit1 Gene Detail
Summary
  • Symbol
    Nit1
  • Name
    nitrilase 1
  • Synonyms
    ESTM30
  • Feature Type
    protein coding gene
  • IDs
    MGI:1350916
    NCBI Gene: 27045
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171342235-171345645 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1350916
protein coding gene Chr1:171338008-171345646 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016756
protein coding gene Chr1:177132216-177139929 (-)
A/J MGP_AJ_G0016736
protein coding gene Chr1:169913754-169921899 (-)
AKR/J MGP_AKRJ_G0016702
protein coding gene Chr1:175009366-175016927 (-)
BALB/cJ MGP_BALBcJ_G0016697
protein coding gene Chr1:170406520-170414352 (-)
C3H/HeJ MGP_C3HHeJ_G0016520
protein coding gene Chr1:175251625-175259192 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017158
protein coding gene Chr1:183023645-183031251 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014866
protein coding gene Chr1:161601156-161608730 (-)
CAST/EiJ MGP_CASTEiJ_G0016101
protein coding gene Chr1:174883739-174892512 (-)
CBA/J MGP_CBAJ_G0016495
protein coding gene Chr1:189531293-189538936 (-)
DBA/2J MGP_DBA2J_G0016602
protein coding gene Chr1:168756323-168763872 (-)
FVB/NJ MGP_FVBNJ_G0016598
protein coding gene Chr1:167104912-167113181 (-)
LP/J MGP_LPJ_G0016673
protein coding gene Chr1:178246019-178253602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016625
protein coding gene Chr1:196810637-196818281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017195
protein coding gene Chr1:174875438-174884442 (-)
PWK/PhJ MGP_PWKPhJ_G0015887
protein coding gene Chr1:167978569-167986222 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015671
protein coding gene Chr1:173662302-173669910 (-)
WSB/EiJ MGP_WSBEiJ_G0016163
protein coding gene Chr1:174994664-175002300 (-)



Homology
more
  • Human Ortholog
    NIT1, nitrilase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NIT1, nitrilase 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4817
    neXtProt AC: NX_Q86X76
    UniProt: Q86X76

  • Chr Location
    1q23.3; chr1:161118072-161125446 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice that are either heterozygous or homozygous for a knock-out allele exhibit increased incidence of N-nitrosomethylbenzylamine (NMBA)-induced tumors in the forestomach (papillomas and dysplasias).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27045 NCBI Gene Model | MGI Sequence Detail 3411 C57BL/6J ±  kb
    transcript NM_001242580 RefSeq | MGI Sequence Detail 1374 C57BL/6  
    polypeptide Q8VDK1 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 9
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1334466, MGI:2138182
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:58686 Pekarsky Y, et al., Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8744-9
    • Latest
      J:242138 Peracchi A, et al., Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc Natl Acad Sci U S A. 2017 Apr 18;114(16):E3233-E3242

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory