Rcn2 MGI Mouse Gene Detail - MGI:1349765

Symbol

Rcn2
Name

reticulocalbin 2
Synonyms

taipoxin-associated calcium binding protein 49, TCBP-49

Feature Type

protein coding gene
IDs

MGI:1349765
NCBI Gene: 26611
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr9:55949129-55966367 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 30.13 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

442 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349765	protein coding gene	Chr9:55949129-55969166 (+)
129S1/SvImJ	ENSMUSG00200032113	protein coding gene	Chr9:53064372-53084759 (+)
A/J	ENSMUSG00195037820	protein coding gene	Chr9:52763004-52783394 (+)
AKR/J	ENSMUSG00220025253	protein coding gene	Chr9:52900174-52920562 (+)
BALB/cJ	ENSMUSG00180016899	protein coding gene	Chr9:52888250-52908291 (+)
C3H/HeJ	ENSMUSG00175020513	protein coding gene	Chr9:52889922-52910308 (+)
C57BL/6NJ	ENSMUSG00215029402	protein coding gene	Chr9:52881628-52901667 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032249	protein coding gene	Chr9:52739389-52759519 (+)
CAST/EiJ	ENSTCUG00005018532	protein coding gene	Chr9:52780341-52800551 (+)
CBA/J	ENSMUSG00210031526	protein coding gene	Chr9:52988904-53009309 (+)
DBA/2J	ENSMUSG00185037285	protein coding gene	Chr9:53020351-53040742 (+)
FVB/NJ	ENSMUSG00205036499	protein coding gene	Chr9:53332656-53353046 (+)
JF1/MsJ	ENSUMUG00000046067	protein coding gene	Chr9:53033724-53053924 (+)
LP/J	ENSMUSG00230032949	protein coding gene	Chr9:53264318-53284704 (+)
NOD/ShiLtJ	ENSMUSG00190030141	protein coding gene	Chr9:53088118-53108504 (+)
NZO/HlLtJ	ENSMUSG00225028033	protein coding gene	Chr9:53295771-53316160 (+)
PWK/PhJ	ENSLUMG00010037203	protein coding gene	Chr9:53000847-53021046 (+)
SPRET/EiJ	ENSMSPG00010022404	protein coding gene	Chr9:54035243-54052603 (+)
WSB/EiJ	ENSIUOG00005036890	protein coding gene	Chr9:52497847-52518236 (+)

Human Ortholog

RCN2, reticulocalbin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCN2, reticulocalbin 2
Synonyms

E6BP, ERC-55, ERC55, TCBP49
Links

HGNC:9935

NCBI Gene ID: 5955

UniProt: Q14257
Chr Location

15q24.3; chr15:76931738-76954393 (+) GRCh38

MGI Vertebrate Homology

Rcn2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RCN2
Gene Tree

Rcn2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

4
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit lowered basal blood pressure and attenuated angiotensin II-induced hypertension.

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All GO Annotations

9
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

740
Tissues

21
cDNA Data

105
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rcn2

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All Sequences

50
RefSeq

4
UniProt

4
CCDS

CCDS23206.1

Ensembl

ENSMUSG00000032320 (Evidence)
NCBI Gene

26611

			Length	Strain/Species	Flank
genomic	26611	NCBI Gene Model \| MGI Sequence Detail	17239	C57BL/6J	± kb
transcript	NM_011992	RefSeq \| MGI Sequence Detail	2042	C57BL/6
polypeptide	Q8BP92	UniProt \| EBI \| MGI Sequence Detail	320	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013839 reticulocalbin-2

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair
GlyGen

Q8BP92 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 105

cDNA 105

Antibodies 1

Microarray probesets 3

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MGI:2142924

Summaries

All 46

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 9
Earliest

J:51718 Dodds D, et al., Novel reticular calcium binding protein is purified on taipoxin columns. J Neurochem. 1995 May;64(5):2339-44
Latest

J:371207 Xie LQ, et al., Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity. Cell Res. 2025 Mar;35(3):165-185

TSS for Rcn2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85227	Chr9:55949146-55949164 (+)	26 bp
Tssr85228	Chr9:55949295-55949317 (+)	177 bp
Tssr85229	Chr9:55960185-55960188 (+)	11,058 bp
Tssr85230	Chr9:55964781-55964821 (+)	15,672 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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