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Dpysl4
Gene Detail
Symbol

Name
ID
Dpysl4
dihydropyrimidinase-like 4
MGI:1349764
Synonyms
Crmp3, CRMP-3, DPY4, Drp-4, Ulip4, unc-33-like phosphoprotein 4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
83.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:139086001-139102704 bp, + strand
From VEGA annotation of GRCm38

  16704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Dpysl4

Human
homologs
Human Homolog DPYSL4, dihydropyrimidinase-like 4
NCBI Gene ID 10570
neXtProt AC  NX_O14531
Human Synonyms  CRMP3, DRP-4, ULIP4
Human Chr (Location)  10q26; chr10:132185060-132205776 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit abnormal neurite outgrowth and lamination in the hippocampus, altered dendrite arborization and spine morphology in hippocampal pyramidal cells, and impaired LTP induction in the CA1 region.
 
Interactions
Dpysl4 interacts with 187 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process pyrimidine nucleobase catabolic process
Component cytoplasm
Function hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (155)    Tissues (153)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 155
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027347 (Evidence)
Ensembl Gene ModelENSMUSG00000025478 (Evidence)
Entrez Gene26757 (Evidence)
UniGene250414
DFCITC1606644, TC1580164
DoTSDT.101268288, DT.522663, DT.101704007, DT.101331710
NIA Mouse Gene IndexU008901
Consensus CDS ProjectCCDS21951.1
International Mouse Knockout Project StatusDpysl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027347 VEGA Gene Model | MGI Sequence Detail 16704 C57BL/6J ±  kb
transcript OTTMUST00000067633 VEGA | MGI Sequence Detail 2727 Not Applicable 
polypeptide OTTMUSP00000034053 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(10) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase 1
InterPro IPR011778 Hydantoinase/dihydropyrimidinase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000006682 dihydropyrimidinase-related protein 4
References
(Earliest) J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
(Latest) J:210402 Quach TT, et al., Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation. J Cell Sci. 2013 Sep 15;126(Pt 18):4262-73
All references(41)
Other
accession IDs
MGI:2141872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory