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Dpysl4
Gene Detail
Symbol

Name
ID
Dpysl4
dihydropyrimidinase-like 4
MGI:1349764
Synonyms
Crmp3, CRMP-3, DPY4, Drp-4, Ulip4, unc-33-like phosphoprotein 4
Feature Type
protein coding gene
Genetic Map
Chromosome 7
83.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:139086001-139102704 bp, + strand
From VEGA annotation of GRCm38

  16704 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4691  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: DPYSL4
Gene Tree: Dpysl4

Human
homologs
DPYSL4, dihydropyrimidinase-like 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10570
neXtProt AC: NX_O14531

Human Synonyms: CRMP3, DRP-4, ULIP4

Human Chr (Location): 10q26; chr10:132184987-132205776 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit abnormal neurite outgrowth and lamination in the hippocampus, altered dendrite arborization and spine morphology in hippocampal pyramidal cells, and impaired LTP induction in the CA1 region.
 
Interactions
Dpysl4 interacts with 187 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process neuron death, neuron projection guidance
Component cytoplasm
Function hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (155)    Tissues (153)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 155
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dpysl4 ; ZFIN dpysl4    NEW 
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000027347 (Evidence)
Ensembl Gene Model ENSMUSG00000025478 (Evidence)
Entrez Gene 26757 (Evidence)
UniGene 250414
DFCI TC1580164, TC1606644
DoTS DT.522663, DT.101268288, DT.101331710, DT.101704007
NIA Mouse Gene Index U008901
Consensus CDS Project CCDS21951.1
International Mouse Phenotyping Consortium Status Dpysl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027347 VEGA Gene Model | MGI Sequence Detail 16704 C57BL/6J ±  kb
transcript OTTMUST00000067633 VEGA | MGI Sequence Detail 2727 Not Applicable 
polypeptide OTTMUSP00000034053 VEGA | MGI Sequence Detail 593 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase 1
InterPro IPR011778 Hydantoinase/dihydropyrimidinase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000006682 dihydropyrimidinase-related protein 4
References
(Earliest) J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
(Latest) J:210402 Quach TT, et al., Mapping CRMP3 domains involved in dendrite morphogenesis and voltage-gated calcium channel regulation. J Cell Sci. 2013 Sep 15;126(Pt 18):4262-73
All references(41)
Other
accession IDs
MGI:2141872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory