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Dpysl2 Gene Detail
Summary
  • Symbol
    Dpysl2
  • Name
    dihydropyrimidinase-like 2
  • Synonyms
    Crmp2, DRP2, TOAD-64, Ulip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349763
    NCBI Gene: 12934
  • Gene Overview
    MyGene.info: DPYSL2
Location & Maps
more
  • Sequence Map
    Chr14:66802864-66868688 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      65825 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRMP2, CRMP-2, DHPRP2, DRP2, DRP-2, N2A3, ULIP2, ULIP-2
  • Links
    NCBI Gene ID: 1808
    neXtProt AC: NX_Q16555
    UniProt: Q16555

  • Chr Location
    8p21.2; chr8:26514193-26658177 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    177
  • Tissues
    157
  • cDNA Data
    5
  • Literature Summary
    9
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016382 VEGA Gene Model | MGI Sequence Detail 65825 C57BL/6J ±  kb
transcript OTTMUST00000039442 VEGA | MGI Sequence Detail 4520 Not Applicable  
polypeptide OTTMUSP00000017622 VEGA | MGI Sequence Detail 572 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    606 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    cDNA 6
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1270853, MGI:2145700
References
more
  • Summaries
    All 51
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:47185 Kamata T, et al., Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance. Brain Res Mol Brain Res. 1998 Mar 1;54(2):219-36
  • Latest
    J:239909 Zhang H, et al., Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat Commun. 2016 Jun 01;7
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/19/2017
MGI 6.10 		The Jackson Laboratory