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Dpysl2 Gene Detail
Summary
  • Symbol
    Dpysl2
  • Name
    dihydropyrimidinase-like 2
  • Synonyms
    Crmp2, DRP2, TOAD-64, Ulip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349763
    NCBI Gene: 12934
  • Alliance
    gene page
  • Transcription Start Sites
    39 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67040313-67106137 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    588 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349763
 protein coding gene Chr14:67040313-67148490 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021498
 protein coding gene Chr14:61503886-61572747 (-)
A/J MGP_AJ_G0021457
 protein coding gene Chr14:60019810-60087594 (-)
AKR/J MGP_AKRJ_G0021433
 protein coding gene Chr14:62091576-62159062 (-)
BALB/cJ MGP_BALBcJ_G0021463
 protein coding gene Chr14:60014678-60081866 (-)
C3H/HeJ MGP_C3HHeJ_G0021240
 protein coding gene Chr14:61815433-61885349 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021902
 protein coding gene Chr14:64313664-64385720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019442
 protein coding gene Chr14:57951902-58018089 (-)
CAST/EiJ MGP_CASTEiJ_G0020757
 protein coding gene Chr14:58268309-58344309 (-)
CBA/J MGP_CBAJ_G0021207
 protein coding gene Chr14:66290662-66357888 (-)
DBA/2J MGP_DBA2J_G0021330
 protein coding gene Chr14:59671207-59738051 (-)
FVB/NJ MGP_FVBNJ_G0021309
 protein coding gene Chr14:59081183-59148172 (-)
LP/J MGP_LPJ_G0021405
 protein coding gene Chr14:62543922-62610036 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021338
 protein coding gene Chr14:65304680-65372747 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021925
 protein coding gene Chr14:61314667-61381942 (-)
PWK/PhJ MGP_PWKPhJ_G0020501
 protein coding gene Chr14:56414692-56483387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020334
 protein coding gene Chr14:57278999-57389787 (-)
WSB/EiJ MGP_WSBEiJ_G0020810
 protein coding gene Chr14:61623359-61694804 (-)



Homology
more
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
  • Synonyms
    CRMP2, CRMP-2, DHPRP2, DRP2, DRP-2, N2A3, ULIP2, ULIP-2
  • Links
    NCBI Gene ID: 1808
    neXtProt AC: NX_Q16555
    UniProt: Q16555

  • Chr Location
    8p21.2; chr8:26514193-26658177 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    158
  • cDNA Data
    7
  • Literature Summary
    15
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022048 Ensembl Gene Model | MGI Sequence Detail 65825 C57BL/6J ±  kb
transcript ENSMUST00000022629 Ensembl | MGI Sequence Detail 4520 Not Applicable  
polypeptide ENSMUSP00000022629 Ensembl | MGI Sequence Detail 572 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1270853, MGI:2145700
References
more
  • Summaries
    All 85
    Developmental Gene Expression 15
    Gene Ontology 10
    Phenotypes 22
  • Earliest
    J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
  • Latest
    J:324984 Shen M, et al., FXR1 regulation of parvalbumin interneurons in the prefrontal cortex is critical for schizophrenia-like behaviors. Mol Psychiatry. 2021;26(11):6845-6867
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
08/09/2022
MGI 6.21 		The Jackson Laboratory