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Dpysl2
Gene Detail
Symbol

Name
ID
Dpysl2
dihydropyrimidinase-like 2
MGI:1349763
Synonyms
Crmp2, DRP2, TOAD-64, Ulip2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
34.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:66802864-66868688 bp, - strand
From VEGA annotation of GRCm38

  65825 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: DPYSL2
Gene Tree: Dpysl2

Human
homologs
DPYSL2, dihydropyrimidinase-like 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1808
neXtProt AC: NX_Q16555

Human Synonyms: CRMP2, CRMP-2, DHPRP2, DRP2, DRP-2, N2A3, ULIP2, ULIP-2

Human Chr (Location): 8p22-p21; chr8:26514193-26658177 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.
 
Interactions
Dpysl2 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process axon guidance, brain development, ...
Component axon, cytoplasm, ...
Function hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (177)    Tissues (157)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 136
Northern blot 7
Western blot 5
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dpysl2 ; ZFIN dpysl2b    NEW 
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016382 (Evidence)
Ensembl Gene Model ENSMUSG00000022048 (Evidence)
Entrez Gene 12934 (Evidence)
DFCI TC1577619, TC1610140
DoTS DT.101164874, DT.87049033, DT.524473
NIA Mouse Gene Index U035708
Consensus CDS Project CCDS27224.1
International Mouse Phenotyping Consortium Status Dpysl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016382 VEGA Gene Model | MGI Sequence Detail 65825 C57BL/6J ±  kb
transcript OTTMUST00000039442 VEGA | MGI Sequence Detail 4520 Not Applicable 
polypeptide OTTMUSP00000017622 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase 1
InterPro IPR011778 Hydantoinase/dihydropyrimidinase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000006680 dihydropyrimidinase-related protein 2
References
(Earliest) J:47185 Kamata T, et al., Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance. Brain Res Mol Brain Res. 1998 Mar 1;54(2):219-36
(Latest) J:204538 Isono T, et al., Amyloid-beta(2)(5)(-)(3)(5) induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2. Neurosci Res. 2013 Nov;77(3):180-5
All references(47)
Other
accession IDs
MGI:1270853, MGI:2145700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory