Dpysl2
Gene Detail

Symbol

Name
ID

Dpysl2
dihydropyrimidinase-like 2
MGI:1349763

Synonyms

Crmp2, DRP2, TOAD-64, Ulip2

Feature Type

protein coding gene

Genetic Map

Chromosome 14
34.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:66802864-66868688 bp, - strand From VEGA annotation of GRCm38   65825 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:74392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Dpysl2

Human
homologs

Human Homolog		DPYSL2, dihydropyrimidinase-like 2
NCBI Gene ID		1808
neXtProt AC		NX_Q16555
Human Synonyms		CRMP2, CRMP-2, DHPRP2, DRP2, DRP-2, N2A3, ULIP2, ULIP-2
Human Chr (Location)		8p22-p21; chr8:26514193-26658177 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.

 

Interactions

Dpysl2 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (32 annotations)

Process	cell differentiation, cytoskeleton organization, ...
Component	axon, cytoplasm, ...
Function	hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (177)    Tissues (157)    Images (26)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	29
RNA in situ	136
Northern blot	7
Western blot	5

cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000016382 (Evidence)
Ensembl Gene Model	ENSMUSG00000022048 (Evidence)
Entrez Gene	12934 (Evidence)
DFCI	TC1577619, TC1610140
DoTS	DT.87049033, DT.524473, DT.101164874
NIA Mouse Gene Index	U035708
Consensus CDS Project	CCDS27224.1
International Mouse Knockout Project Status	Dpysl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016382	VEGA Gene Model | MGI Sequence Detail	65825	C57BL/6J
transcript	OTTMUST00000039442	VEGA | MGI Sequence Detail	4520	Not Applicable
polypeptide	OTTMUSP00000017622	VEGA | MGI Sequence Detail	572	Not Applicable

All sequences(23) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(362 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR006680	Amidohydrolase 1
InterPro	IPR011778	Hydantoinase/dihydropyrimidinase
InterPro	IPR011059	Metal-dependent hydrolase, composite domain
Protein Ontology	PR:000006680	dihydropyrimidinase-related protein 2

References

(Earliest) J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
(Latest) J:204538 Isono T, et al., Amyloid-beta(2)(5)(-)(3)(5) induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2. Neurosci Res. 2013 Nov;77(3):180-5
All references(50)

Other
accession IDs

MGI:1270853, MGI:2145700