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Dpysl2 Gene Detail
Summary
  • Symbol
    Dpysl2
  • Name
    dihydropyrimidinase-like 2
  • Synonyms
    Crmp2, DRP2, TOAD-64, Ulip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349763
    NCBI Gene: 12934
  • Alliance
    gene page
  • Transcription Start Sites
    46 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67040313-67148410 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3273 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349763
 protein coding gene Chr14:67040313-67148490 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021498
 protein coding gene Chr14:61503886-61572747 (-)
A/J MGP_AJ_G0021457
 protein coding gene Chr14:60019810-60087594 (-)
AKR/J MGP_AKRJ_G0021433
 protein coding gene Chr14:62091576-62159062 (-)
BALB/cJ MGP_BALBcJ_G0021463
 protein coding gene Chr14:60014678-60081866 (-)
C3H/HeJ MGP_C3HHeJ_G0021240
 protein coding gene Chr14:61815433-61885349 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021902
 protein coding gene Chr14:64313664-64385720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019442
 protein coding gene Chr14:57951902-58018089 (-)
CAST/EiJ MGP_CASTEiJ_G0020757
 protein coding gene Chr14:58268309-58344309 (-)
CBA/J MGP_CBAJ_G0021207
 protein coding gene Chr14:66290662-66357888 (-)
DBA/2J MGP_DBA2J_G0021330
 protein coding gene Chr14:59671207-59738051 (-)
FVB/NJ MGP_FVBNJ_G0021309
 protein coding gene Chr14:59081183-59148172 (-)
LP/J MGP_LPJ_G0021405
 protein coding gene Chr14:62543922-62610036 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021338
 protein coding gene Chr14:65304680-65372747 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021925
 protein coding gene Chr14:61314667-61381942 (-)
PWK/PhJ MGP_PWKPhJ_G0020501
 protein coding gene Chr14:56414692-56483387 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020334
 protein coding gene Chr14:57278999-57389787 (-)
WSB/EiJ MGP_WSBEiJ_G0020810
 protein coding gene Chr14:61623359-61694804 (-)



Homology
more
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPYSL2, dihydropyrimidinase like 2
  • Synonyms
    CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2
  • Links
    NCBI Gene ID: 1808
    UniProt: Q16555

  • Chr Location
    8p21.2; chr8:26514031-26658178 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    168
  • cDNA Data
    7
  • Literature Summary
    18
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022048 Ensembl Gene Model | MGI Sequence Detail 108098 C57BL/6J ±  kb
transcript ENSMUST00000249932 Ensembl | MGI Sequence Detail 4681 Not Applicable  
polypeptide ENSMUSP00000160026 Ensembl | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006680 dihydropyrimidinase-related protein 2
    (term hierarchy)
  • PDB
    5UQC
  • InterPro Domains
    IPR006680 Amidohydrolase-related
    IPR011778 Hydantoinase/dihydropyrimidinase
    IPR032466 Metal-dependent hydrolase
    IPR011059 Metal-dependent hydrolase, composite domain superfamily
    IPR050378 Metallo-dependent Hydrolases Superfamily
  • GlyGen
    O08553 14 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (6 sites)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1270853, MGI:2145700
References
more
  • Summaries
    All 104
    Developmental Gene Expression 18
    Gene Ontology 15
    Phenotypes 32
  • Earliest
    J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
  • Latest
    J:363113 Borrelli C, et al., In vivo interaction screening reveals liver-derived constraints to metastasis. Nature. 2024 Aug;632(8024):411-418
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory