About   Help   FAQ
Dpysl2
Gene Detail
 Symbol
Name
ID
Dpysl2
dihydropyrimidinase-like 2
MGI:1349763
Synonyms Crmp2, DRP2, TOAD-64, Ulip2
Feature Type protein coding gene
Genetic Map
Chromosome 14
34.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:66802864-66868688 bp, - strand
From VEGA annotation of GRCm38

  65825 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74392  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Dpysl2

Human
homologs
Human Homolog DPYSL2, dihydropyrimidinase-like 2
NCBI Gene ID 1808
neXtProt AC  NX_Q16555
Human Synonyms  CRMP2, CRMP-2, DHPRP2, DRP2, DRP-2, N2A3, ULIP2, ULIP-2
Human Chr (Location)  8p22-p21; chr8:26514193-26658177 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.
 
Interactions
Dpysl2 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process cell differentiation, cytoskeleton organization, ...
Component axon, cytoplasm, ...
Function hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (177)    Tissues (156)    Images (26)
Theiler Stages: 10, 18, 19, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 136
Northern blot 7
Western blot 5
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016382 (Evidence)
Ensembl Gene ModelENSMUSG00000022048 (Evidence)
Entrez Gene12934 (Evidence)
DFCITC1577619, TC1610140
DoTSDT.101164874, DT.524473, DT.87049033
NIA Mouse Gene IndexU035708
Consensus CDS ProjectCCDS27224.1
International Mouse Knockout Project StatusDpysl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016382 VEGA Gene Model | MGI Sequence Detail 65825 C57BL/6J ±  kb
transcript OTTMUST00000039442 VEGA | MGI Sequence Detail 4520 Not Applicable 
polypeptide OTTMUSP00000017622 VEGA | MGI Sequence Detail 572 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(362 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase 1
InterPro IPR011778 Hydantoinase/dihydropyrimidinase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000006680 dihydropyrimidinase-related protein 2
References (Earliest) J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
(Latest) J:204538 Isono T, et al., Amyloid-beta(2)(5)(-)(3)(5) induces impairment of cognitive function and long-term potentiation through phosphorylation of collapsin response mediator protein 2. Neurosci Res. 2013 Nov;77(3):180-5
All references(48)
Other
accession IDs
MGI:1270853, MGI:2145700

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory