Dpysl2 MGI Mouse Gene Detail - MGI:1349763 - dihydropyrimidinase-like 2

Dpysl2 Gene Detail

Symbol

Dpysl2
Name

dihydropyrimidinase-like 2
Synonyms

Crmp2, DRP2, TOAD-64, Ulip2

Feature Type

protein coding gene
IDs

MGI:1349763
NCBI Gene: 12934
Gene Overview

MyGene.info: DPYSL2

Sequence Map

Chr14:66802864-66868688 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

65825 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.60 cM
Mapping Data

3 experiments

Human Ortholog

DPYSL2, dihydropyrimidinase like 2

Vertebrate Orthologs

9

Human Ortholog

DPYSL2, dihydropyrimidinase like 2
Orthology source: HomoloGene, HGNC
Synonyms

CRMP2, CRMP-2, DHPRP2, DRP2, DRP-2, N2A3, ULIP2, ULIP-2
Links

HGNC:3014

NCBI Gene ID: 1808

neXtProt AC: NX_Q16555

UniProt: Q16555
Chr Location

8p21.2; chr8:26514193-26658177 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 74392
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DPYSL2
Gene Tree

Dpysl2

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Targeted

5
Genomic Mutations

1 involving Dpysl2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.

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All GO Annotations

39
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

177
Tissues

157
cDNA Data

5
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN dpysl2b

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Dpysl2 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

17
RefSeq

4
UniProt

1
CCDS

CCDS27224.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016382	VEGA Gene Model \| MGI Sequence Detail	65825	C57BL/6J	± kb
transcript	OTTMUST00000039442	VEGA \| MGI Sequence Detail	4520	Not Applicable
polypeptide	OTTMUSP00000017622	VEGA \| MGI Sequence Detail	572	Not Applicable

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SNPs within 2kb

606 from dbSNP Build 142

RFLP

1

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UniProt

1 Sequence
Protein Ontology

PR:000006680 dihydropyrimidinase-related protein 2

(term hierarchy)
PDB

5UQC
InterPro Domains

IPR006680 Amidohydrolase-related

IPR030615 Dihydropyrimidinase-related protein 2

IPR011778 Hydantoinase/dihydropyrimidinase

IPR032466 Metal-dependent hydrolase

IPR011059 Metal-dependent hydrolase, composite domain

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 4

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MGI:1270853, MGI:2145700

Summaries

All 51

Developmental Gene Expression 9

Gene Ontology 9

Phenotypes 11
Earliest

J:47185 Kamata T, et al., Isolation and characterization of a bovine neural specific protein (CRMP-2) cDNA homologous to unc-33, a C. elegans gene implicated in axonal outgrowth and guidance. Brain Res Mol Brain Res. 1998 Mar 1;54(2):219-36
Latest

J:239909 Zhang H, et al., Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice. Nat Commun. 2016 Jun 01;7

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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