Dpysl2 MGI Mouse Gene Detail - MGI:1349763 - dihydropyrimidinase-like 2

Symbol

Dpysl2
Name

dihydropyrimidinase-like 2
Synonyms

Crmp2, DRP2, TOAD-64, Ulip2

Feature Type

protein coding gene
IDs

MGI:1349763
NCBI Gene: 12934
Gene Overview

MyGene.info: DPYSL2
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr14:66802864-66868688 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.60 cM
Mapping Data

3 experiments

SNPs within 2kb

606 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349763	protein coding gene	Chr14:66802864-66911041 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021498	protein coding gene	Chr14:61503886-61572747 (-)
A/J	MGP_AJ_G0021457	protein coding gene	Chr14:60019810-60087594 (-)
AKR/J	MGP_AKRJ_G0021433	protein coding gene	Chr14:62091576-62159062 (-)
BALB/cJ	MGP_BALBcJ_G0021463	protein coding gene	Chr14:60014678-60081866 (-)
C3H/HeJ	MGP_C3HHeJ_G0021240	protein coding gene	Chr14:61815433-61885349 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021902	protein coding gene	Chr14:64313664-64385720 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019442	protein coding gene	Chr14:57951902-58018089 (-)
CAST/EiJ	MGP_CASTEiJ_G0020757	protein coding gene	Chr14:58268309-58344309 (-)
CBA/J	MGP_CBAJ_G0021207	protein coding gene	Chr14:66290662-66357888 (-)
DBA/2J	MGP_DBA2J_G0021330	protein coding gene	Chr14:59671207-59738051 (-)
FVB/NJ	MGP_FVBNJ_G0021309	protein coding gene	Chr14:59081183-59148172 (-)
LP/J	MGP_LPJ_G0021405	protein coding gene	Chr14:62543922-62610036 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021338	protein coding gene	Chr14:65304680-65372747 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021925	protein coding gene	Chr14:61314667-61381942 (-)
PWK/PhJ	MGP_PWKPhJ_G0020501	protein coding gene	Chr14:56414692-56483387 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020334	protein coding gene	Chr14:57278999-57389787 (-)
WSB/EiJ	MGP_WSBEiJ_G0020810	protein coding gene	Chr14:61623359-61694804 (-)

Human Ortholog

DPYSL2, dihydropyrimidinase like 2

Vertebrate Orthologs

9

Human Ortholog

DPYSL2, dihydropyrimidinase like 2
Orthology source: HomoloGene, HGNC
Synonyms

CRMP2, CRMP-2, DHPRP2, DRP2, DRP-2, N2A3, ULIP2, ULIP-2
Links

HGNC:3014

NCBI Gene ID: 1808

neXtProt AC: NX_Q16555

UniProt: Q16555
Chr Location

8p21.2; chr8:26514193-26658177 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 74392
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DPYSL2
Gene Tree

Dpysl2

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Phenotype Summary

2 phenotypes from 1 allele in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Targeted

9
Genomic Mutations

1 involving Dpysl2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available

Mice homozygous for a knock-in allele exhibit abnormal dendritic patterning.

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All GO Annotations

41
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

158
cDNA Data

7
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dpysl2

ZFIN dpysl2b

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Dpysl2 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

34
RefSeq

6
UniProt

1
CCDS

CCDS27224.1

Ensembl

ENSMUSG00000022048 (Evidence)
NCBI Gene

12934

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022048	Ensembl Gene Model \| MGI Sequence Detail	65825	C57BL/6J	± kb
transcript	ENSMUST00000022629	Ensembl \| MGI Sequence Detail	4520	Not Applicable
polypeptide	ENSMUSP00000022629	Ensembl \| MGI Sequence Detail	572	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006680 dihydropyrimidinase-related protein 2

(term hierarchy)
PDB

5UQC
InterPro Domains

IPR006680 Amidohydrolase-related

IPR030615 Dihydropyrimidinase-related protein 2

IPR011778 Hydantoinase/dihydropyrimidinase

IPR032466 Metal-dependent hydrolase

IPR011059 Metal-dependent hydrolase, composite domain superfamily

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 4

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MGI:1270853, MGI:2145700

Summaries

All 78

Developmental Gene Expression 14

Gene Ontology 10

Phenotypes 18
Earliest

J:37992 Hamajima N, et al., A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution. Gene. 1996 Nov 21;180(1-2):157-63
Latest

J:299918 Ikezu S, et al., Tau-tubulin kinase 1 and amyloid-beta peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta Neuropathol Commun. 2020 Feb 4;8(1):12

TSS for Dpysl2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129358	Chr14:66869077-66869103 (-)	-402 bp
Tssr129357	Chr14:66869018-66869067 (-)	-355 bp
Tssr129356	Chr14:66868919-66868948 (-)	-246 bp
Tssr129355	Chr14:66868572-66868684 (-)	60 bp
Tssr129354	Chr14:66868421-66868432 (-)	261 bp
Tssr129353	Chr14:66868114-66868148 (-)	557 bp
Tssr129324	Chr14:66804502-66804520 (-)	64,177 bp
Tssr129323	Chr14:66804011-66804025 (-)	64,670 bp
Tssr129322	Chr14:66803538-66803560 (-)	65,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/06/2021 MGI 6.16