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Pabpc2 Gene Detail
Summary
  • Symbol
    Pabpc2
  • Name
    poly(A) binding protein, cytoplasmic 2
  • Synonyms
    Pabp2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349723
    NCBI Gene: 18459
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:39906550-39909135 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 21.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    30 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349723
 protein coding gene Chr18:39906550-39909135 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024369
 protein coding gene Chr18:38325017-38327602 (+)
A/J MGP_AJ_G0024336
 protein coding gene Chr18:36993838-36996423 (+)
AKR/J MGP_AKRJ_G0024305
 protein coding gene Chr18:37984293-37986878 (+)
BALB/cJ MGP_BALBcJ_G0024336
 protein coding gene Chr18:37037301-37039886 (+)
C3H/HeJ MGP_C3HHeJ_G0024102
 protein coding gene Chr18:38058188-38060773 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024778
 protein coding gene Chr18:39637176-39639761 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022217
 protein coding gene Chr18:36963654-36966237 (+)
CAST/EiJ MGP_CASTEiJ_G0023577
 protein coding gene Chr18:38030188-38032774 (+)
CBA/J MGP_CBAJ_G0024072
 protein coding gene Chr18:40837721-40840306 (+)
DBA/2J MGP_DBA2J_G0024202
 protein coding gene Chr18:36564309-36566894 (+)
FVB/NJ MGP_FVBNJ_G0024168
 protein coding gene Chr18:36289369-36291954 (+)
LP/J MGP_LPJ_G0024286
 protein coding gene Chr18:38360153-38362738 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024199
 protein coding gene Chr18:42029178-42031763 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024827
 protein coding gene Chr18:37870935-37873520 (+)
PWK/PhJ MGP_PWKPhJ_G0023321
 protein coding gene Chr18:36811751-36814337 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023126
 protein coding gene Chr18:38115161-38117744 (+)
WSB/EiJ MGP_WSBEiJ_G0023640
 protein coding gene Chr18:37762072-37764657 (+)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
Mice homozygous for a null allele exhibit normal behavior, body weight, and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    9
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    743
  • Tissues
    29
  • cDNA Data
    20
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18459 NCBI Gene Model | MGI Sequence Detail 2586 C57BL/6J ±  kb
transcript NM_011033 RefSeq | MGI Sequence Detail 2586 C57BL/6  
polypeptide NP_035163 RefSeq | MGI Sequence Detail 628 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR036053 PABC (PABP) domain
    IPR034364 PABP, RNA recognition motif 1
    IPR045305 PABP, RNA recognition motif 2
    IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4
    IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR003954 RNA recognition motif domain, eukaryote
Molecular
Reagents
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  • All nucleic 24
    Genomic 1
    cDNA 20
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-27037, MGI:104674
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 2
  • Earliest
    J:21823 Kleene KC, et al., Developmental expression of poly(A) binding protein mRNAs during spermatogenesis in the mouse. Mol Reprod Dev. 1994 Dec;39(4):355-64
  • Latest
    J:319556 Kashiwabara S, et al., Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis. J Reprod Dev. 2016 Jun 17;62(3):305-10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory