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Pabpc1
Gene Detail
Symbol

Name
ID
Pabpc1
poly(A) binding protein, cytoplasmic 1
MGI:1349722
Synonyms
Pabp1, Pabpl1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
14.51 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:36595661-36608973 bp, - strand
From VEGA annotation of GRCm38

  13313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37638  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PABPC1
Gene Tree: Pabpc1

Human
homologs
PABPC1, poly(A) binding protein, cytoplasmic 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 26986
neXtProt AC: NX_P11940

Human Synonyms: PAB1, PABP, PABP1, PABPC2, PABPL1

Human Chr (Location): 8q22.2-q23; chr8:100702916-100722998 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(27) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Pabpc1 interacts with 144 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process gene silencing by RNA, mRNA processing, ...
Component catalytic step 2 spliceosome, cytoplasm, ...
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (69)    Tissues (44)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
Northern blot 11
RT-PCR 36
cDNA source data(1107)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PABPC1 ; Xenbase pabpc1    NEW 
Molecular
reagents
All nucleic(1112) cDNA(1107) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000019779 (Evidence)
Ensembl Gene Model ENSMUSG00000022283 (Evidence)
Entrez Gene 18458 (Evidence)
UniGene 371570
DFCI TC1573656, TC1587736
DoTS DT.97334926, DT.97334929, DT.94282327, DT.87073831, DT.87073830, DT.101126790
NIA Mouse Gene Index U036097, U125240, U087549
Consensus CDS Project CCDS27431.1
International Mouse Phenotyping Consortium Status Pabpc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019779 VEGA Gene Model | MGI Sequence Detail 13313 C57BL/6J ±  kb
transcript OTTMUST00000047296 VEGA | MGI Sequence Detail 2817 Not Applicable 
polypeptide OTTMUSP00000021349 VEGA | MGI Sequence Detail 636 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4
InterPro IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000012204 polyadenylate-binding protein 1
References
(Earliest) J:10879 Rhyner TA, et al., Isolation of cDNAs from a mouse astroglial cell line by a subtracted cDNA library. J Neurosci Res. 1990 Oct;27(2):144-52
(Latest) J:216392 Kraushar ML, et al., Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3815-24
All references(56)
Other
accession IDs
MGD-MRK-13120, MGD-MRK-27031, MGI:104668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory