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Pabpc1
Gene Detail
 Symbol
Name
ID
Pabpc1
poly(A) binding protein, cytoplasmic 1
MGI:1349722
Synonyms Pabp1, Pabpl1
Feature Type protein coding gene
Genetic Map
Chromosome 15
14.51 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:36595661-36608973 bp, - strand
From VEGA annotation of GRCm38

  13313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37638  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Pabpc1

Human
homologs
Human Homolog PABPC1, poly(A) binding protein, cytoplasmic 1
NCBI Gene ID 26986
neXtProt AC  NX_P11940
Human Synonyms  PAB1, PABP, PABP1, PABPC2, PABPL1
Human Chr (Location)  8q22.2-q23; chr8:100702916-100722482 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(27) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pabpc1 interacts with 144 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process gene silencing by RNA, mRNA processing, ...
Component catalytic step 2 spliceosome, cytoplasm, ...
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (69)    Tissues (43)    Images (5)
Theiler Stages: 1, 2, 3, 5, 11, 13, 21, 27, 28
Assay TypeResults
RNA in situ 22
Northern blot 11
RT-PCR 36
cDNA source data(1107)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(1112) cDNA(1107) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019779 (Evidence)
Ensembl Gene ModelENSMUSG00000022283 (Evidence)
Entrez Gene18458 (Evidence)
UniGene371570
DFCITC1573656, TC1587736
DoTSDT.101126790, DT.87073830, DT.87073831, DT.94282327, DT.97334926, DT.97334929
NIA Mouse Gene IndexU036097, U087549, U125240
Consensus CDS ProjectCCDS27431.1
International Mouse Knockout Project StatusPabpc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019779 VEGA Gene Model | MGI Sequence Detail 13313 C57BL/6J ±  kb
transcript OTTMUST00000047296 VEGA | MGI Sequence Detail 2817 Not Applicable 
polypeptide OTTMUSP00000021349 VEGA | MGI Sequence Detail 636 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR006515 Polyadenylate binding protein, human types 1, 2, 3, 4
InterPro IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000012204 polyadenylate-binding protein 1
References (Earliest) J:10879 Rhyner TA, et al., Isolation of cDNAs from a mouse astroglial cell line by a subtracted cDNA library. J Neurosci Res. 1990 Oct;27(2):144-52
(Latest) J:194412 Takahashi M, et al., Stress granules inhibit apoptosis by reducing reactive oxygen species production. Mol Cell Biol. 2013 Feb;33(4):815-29
All references(55)
Other
accession IDs
MGD-MRK-13120, MGD-MRK-27031, MGI:104668

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory