About   Help   FAQ
Ncor1 Gene Detail
Summary
  • Symbol
    Ncor1
  • Name
    nuclear receptor co-repressor 1
  • Synonyms
    5730405M06Rik, A230020K14Rik, mKIAA1047, N-CoR, Rxrip13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349717
    NCBI Gene: 20185
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:62316426-62458541 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      142116 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 38.08 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hN-CoR, N-CoR, N-CoR1, PPP1R109, TRAC1
  • Links
    NCBI Gene ID: 9611
    neXtProt AC: NX_O75376
    UniProt: O75376

  • Chr Location
    17p12-p11.2; chr17:16030094-16216746 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38166
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NCOR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation in this gene exhibit embryonic lethality with erythrocytic, thymocytic and central nervous system development abnormalities. Mice homozygous for a hypomorphic allele exhibit increased thyroid hormone sensitivity under hypothyroid conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005855 VEGA Gene Model | MGI Sequence Detail 142116 C57BL/6J ±  kb
    transcript OTTMUST00000013021 VEGA | MGI Sequence Detail 9037 Not Applicable  
    polypeptide OTTMUSP00000006054 VEGA | MGI Sequence Detail 2454 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      558 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 34
      Primer pair 2
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24052, MGI:103184, MGI:2441784, MGI:2444535
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 14
      Gene Ontology 42
      Phenotypes 46
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:254331 Wang J, et al., NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun. 2017 Oct 16;8(1):959

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory