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Ncor1 Gene Detail
Summary
  • Symbol
    Ncor1
  • Name
    nuclear receptor co-repressor 1
  • Synonyms
    5730405M06Rik, A230020K14Rik, mKIAA1047, N-CoR, Rxrip13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349717
    NCBI Gene: 20185
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:62316426-62458541 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 38.08 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    558 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349717
protein coding gene Chr11:62315663-62458703 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018453
protein coding gene Chr11:62336514-62499767 (-)
A/J MGP_AJ_G0018422
protein coding gene Chr11:60041258-60189503 (-)
AKR/J MGP_AKRJ_G0018392
protein coding gene Chr11:61895333-62044166 (-)
BALB/cJ MGP_BALBcJ_G0018393
protein coding gene Chr11:60327244-60471375 (-)
C3H/HeJ MGP_C3HHeJ_G0018206
protein coding gene Chr11:61866545-62025267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018845
protein coding gene Chr11:64302508-64460841 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016491
protein coding gene Chr11:57141351-57284365 (-)
CAST/EiJ MGP_CASTEiJ_G0017763
protein coding gene Chr11:62006016-62153356 (-)
CBA/J MGP_CBAJ_G0018180
protein coding gene Chr11:67085288-67263043 (-)
DBA/2J MGP_DBA2J_G0018289
protein coding gene Chr11:59594107-59739305 (-)
FVB/NJ MGP_FVBNJ_G0018280
protein coding gene Chr11:59272770-59415521 (-)
LP/J MGP_LPJ_G0018362
protein coding gene Chr11:62895063-63047646 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018304
protein coding gene Chr11:68078908-68239659 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018886
protein coding gene Chr11:62042585-62194711 (-)
PWK/PhJ MGP_PWKPhJ_G0017536
protein coding gene Chr11:60215123-60362412 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017326
protein coding gene Chr11:61884544-62037652 (-)
WSB/EiJ MGP_WSBEiJ_G0017815
protein coding gene Chr11:61644620-61795980 (-)



Homology
more
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hN-CoR, N-CoR, N-CoR1, PPP1R109, TRAC1
  • Links
    NCBI Gene ID: 9611
    neXtProt AC: NX_O75376
    UniProt: O75376

  • Chr Location
    17p12-p11.2; chr17:16030094-16216746 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38166
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NCOR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    64 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation in this gene exhibit embryonic lethality with erythrocytic, thymocytic and central nervous system development abnormalities. Mice homozygous for a hypomorphic allele exhibit increased thyroid hormone sensitivity under hypothyroid conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018501 Ensembl Gene Model | MGI Sequence Detail 142116 C57BL/6J ±  kb
    transcript ENSMUST00000101066 Ensembl | MGI Sequence Detail 8852 Not Applicable  
    polypeptide ENSMUSP00000098627 Ensembl | MGI Sequence Detail 2454 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 34
      Primer pair 2
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-24052, MGI:103184, MGI:2441784, MGI:2444535
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 15
      Gene Ontology 43
      Phenotypes 47
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:256926 Mendoza A, et al., NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8458-E8467

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory