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Ncor1 Gene Detail
Summary
  • Symbol
    Ncor1
  • Name
    nuclear receptor co-repressor 1
  • Synonyms
    5730405M06Rik, A230020K14Rik, mKIAA1047, N-CoR, Rxrip13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349717
    NCBI Gene: 20185
Location & Maps
more
  • Sequence Map
    Chr11:62316426-62458541 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      142116 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 38.08 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NCOR1, nuclear receptor corepressor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hN-CoR, N-CoR, N-CoR1, PPP1R109, TRAC1
  • Links
    NCBI Gene ID: 9611
    neXtProt AC: NX_O75376

  • Chr Location
    17p11.2; chr17:16030094-16216746 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38166
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NCOR1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    64 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    555
  • Chemically induced (other)
    1
  • Gene trapped
    547
  • Targeted
    7
  • Genomic Mutations
    1 involving Ncor1
  • Incidental Mutations
Mice homozygous for a targeted mutation in this gene exhibit embryonic lethality with erythrocytic, thymocytic and central nervous system development abnormalities. Mice homozygous for a hypomorphic allele exhibit increased thyroid hormone sensitivity under hypothyroid conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005855 VEGA Gene Model | MGI Sequence Detail 142116 C57BL/6J ±  kb
transcript OTTMUST00000013021 VEGA | MGI Sequence Detail 9037 Not Applicable  
polypeptide OTTMUSP00000006054 VEGA | MGI Sequence Detail 2454 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    558 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 37
    cDNA 34
    Primer pair 2
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-24052, MGI:103184, MGI:2441784, MGI:2444535
References
more
  • Summaries
    All 102
    Developmental Gene Expression 13
    Gene Ontology 35
    Phenotypes 39
  • Earliest
    J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
  • Latest
    J:229817 Hua G, et al., Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex. Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E635-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory