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Spo11 Gene Detail
Summary
  • Symbol
    Spo11
  • Name
    SPO11 meiotic protein covalently bound to DSB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349669
    NCBI Gene: 26972
Location & Maps
more
  • Sequence Map
    Chr2:172977700-172993576 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15877 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SPO11, SPO11, initiator of meiotic double stranded breaks
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPO11, SPO11, initiator of meiotic double stranded breaks
    Orthology source: HomoloGene
  • Synonyms
    CT35, SPATA43, TOPVIA
  • Links
    NCBI Gene ID: 23626
    neXtProt AC: NX_Q9Y5K1

  • Chr Location
    20q13.31; chr20:57329759-57343993 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 8 alleles in 11 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Targeted
    12
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation are sterile. Mutant males exhibit loss of spermatocytes in early prophase, while mutant females exhibit oocyte loss soon after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016682 VEGA Gene Model | MGI Sequence Detail 15877 C57BL/6J ±  kb
transcript OTTMUST00000040396 VEGA | MGI Sequence Detail 1709 Not Applicable  
polypeptide OTTMUSP00000018047 VEGA | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    221 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015553 meiotic recombination protein SPO11
  • InterPro Domains
    IPR004084 Meiosis-specific protein Spo11
    IPR013048 Meiotic recombination, Spo11
    IPR002815 Spo11/DNA topoisomerase VI subunit A
    IPR013049 Spo11/DNA topoisomerase VI, subunit A, N-terminal
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 18
    Genomic 2
    cDNA 11
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138956
References
more
  • Summaries
    All 90
    Developmental Gene Expression 17
    Gene Ontology 12
    Phenotypes 53
  • Earliest
    J:58262 Romanienko PJ, et al., Cloning, characterization, and localization of mouse and human SPO11. Genomics. 1999 Oct 15;61(2):156-69
  • Latest
    J:229524 Robert T, et al., The TopoVIB-Like protein family is required for meiotic DNA double-strand break formation. Science. 2016 Feb 26;351(6276):943-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory