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Spo11 Gene Detail
Summary
  • Symbol
    Spo11
  • Name
    SPO11 meiotic protein covalently bound to DSB
  • Synonyms
    Spo11a, Spo11b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349669
    NCBI Gene: 26972
Location & Maps
more
  • Sequence Map
    Chr2:172977700-172993576 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      15877 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 95.64 cM, cytoband H4
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SPO11, SPO11, initiator of meiotic double stranded breaks
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SPO11, SPO11, initiator of meiotic double stranded breaks
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT35, SPATA43, TOPVIA
  • Links
    NCBI Gene ID: 23626
    neXtProt AC: NX_Q9Y5K1
    UniProt: Q9Y5K1

  • Chr Location
    20q13.31; chr20:57329757-57343993 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 8 alleles in 11 genetic backgrounds
    15 phenotypes from multigenic genotypes
    4 images
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation are sterile. Mutant males exhibit loss of spermatocytes in early prophase, while mutant females exhibit oocyte loss soon after birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    32
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    102
  • Tissues
    21
  • cDNA Data
    11
  • Literature Summary
    21
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016682 VEGA Gene Model | MGI Sequence Detail 15877 C57BL/6J ±  kb
transcript OTTMUST00000040396 VEGA | MGI Sequence Detail 1709 Not Applicable  
polypeptide OTTMUSP00000018047 VEGA | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    221 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    Genomic 2
    cDNA 11
    Primer pair 6
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2138956
References
more
  • Summaries
    All 99
    Developmental Gene Expression 21
    Gene Ontology 14
    Phenotypes 59
  • Earliest
    J:58262 Romanienko PJ, et al., Cloning, characterization, and localization of mouse and human SPO11. Genomics. 1999 Oct 15;61(2):156-69
  • Latest
    J:240753 Alavattam KG, et al., Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications. Cell Rep. 2016 Oct 18;17(4):1141-1157
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/12/2017
MGI 6.10 		The Jackson Laboratory