Spo11
Gene Detail

Symbol

Name
ID

Spo11
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
MGI:1349669

Feature Type

protein coding gene

Genetic Map

Chromosome 2
95.64 cM, cytoband H4
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:172977700-172993576 bp, + strand From VEGA annotation of GRCm38   15877 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:6059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Spo11

Human
homologs

Human Homolog		SPO11, SPO11 meiotic protein covalently bound to DSB
NCBI Gene ID		23626
neXtProt AC		NX_Q9Y5K1
Human Synonyms		CT35, SPATA43, TOPVIA
Human Chr (Location)		20q13.31; chr20:57329775-57343993 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from APF )
 

Homozygotes for a targeted null mutation are sterile. Mutant males exhibit loss of spermatocytes in early prophase, while mutant females exhibit oocyte loss soon after birth.

 

Interactions

Spo11 interacts with 62 markers (Mir19a, Mir25, Mir27a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	DNA catabolic process, endonucleolytic, DNA metabolic process, ...
Component	chromosome, chromosome, telomeric region, ...
Function	ATP binding, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (17 records)

Data Summary: Results (90)    Tissues (19)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	44
Northern blot	8
RT-PCR	38

cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(18) Genomic(2) cDNA(11) Primer pair(4) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000016682 (Evidence)
Ensembl Gene Model	ENSMUSG00000005883 (Evidence)
Entrez Gene	26972 (Evidence)
UniGene	23495
DFCI	TC1593827, TC1596763, TC1583981, TC1593222, TC1738126, TC1616207, TC1596836
DoTS	DT.94184028, DT.101164367, DT.97408289, DT.91372564, DT.50315251
NIA Mouse Gene Index	U002906
Consensus CDS Project	CCDS17137.1, CCDS50811.1, CCDS50812.1
International Mouse Knockout Project Status	Spo11

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016682	VEGA Gene Model | MGI Sequence Detail	15877	C57BL/6J
transcript	OTTMUST00000040396	VEGA | MGI Sequence Detail	1709	Not Applicable
polypeptide	OTTMUSP00000018047	VEGA | MGI Sequence Detail	396	Not Applicable

All sequences(73) RefSeq(20) UniProt(2)

Polymorphisms

RFLP(2) : SNPs within 2kb(220 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004084	Meiosis-specific protein Spo11
InterPro	IPR013048	Meiotic recombination, Spo11
InterPro	IPR002815	Spo11/DNA topoisomerase VI, subunit A
InterPro	IPR013049	Spo11/DNA topoisomerase VI, subunit A, N-terminal
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
Protein Ontology	PR:000015553	meiotic recombination protein SPO11

References

(Earliest) J:58262 Romanienko PJ, et al., Cloning, characterization, and localization of mouse and human SPO11. Genomics. 1999 Oct 15;61(2):156-69
(Latest) J:215795 Broering TJ, et al., BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis. J Cell Biol. 2014 Jun 9;205(5):663-75
All references(89)

Other
accession IDs

MGI:2138956