About   Help   FAQ
Spo11
Gene Detail
 Symbol
Name
ID
Spo11
SPO11 meiotic protein covalently bound to DSB homolog (S. cerevisiae)
MGI:1349669
Feature Type protein coding gene
Genetic Map
Chromosome 2
95.64 cM, cytoband H4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:172977700-172993576 bp, + strand
From VEGA annotation of GRCm38

  15877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Spo11

Human
homologs
Human Homolog SPO11, SPO11 meiotic protein covalently bound to DSB
NCBI Gene ID 23626
neXtProt AC  NX_Q9Y5K1
Human Synonyms  CT35, SPATA43, TOPVIA
Human Chr (Location)  20q13.31; chr20:57329775-57343993 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation are sterile. Mutant males exhibit loss of spermatocytes in early prophase, while mutant females exhibit oocyte loss soon after birth.
 
Interactions
Spo11 interacts with 62 markers (Mir19a, Mir25, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process DNA catabolic process, endonucleolytic, DNA metabolic process, ...
Component chromosome, chromosome, telomeric region, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (90)    Tissues (18)    Images (23)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 44
Northern blot 8
RT-PCR 38
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(2) cDNA(11) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016682 (Evidence)
Ensembl Gene ModelENSMUSG00000005883 (Evidence)
Entrez Gene26972 (Evidence)
UniGene23495
DFCITC1583981, TC1593222, TC1593827, TC1596763, TC1596836, TC1616207, TC1738126
DoTSDT.101164367, DT.50315251, DT.91372564, DT.94184028, DT.97408289
NIA Mouse Gene IndexU002906
Consensus CDS ProjectCCDS17137.1, CCDS50811.1, CCDS50812.1
International Mouse Knockout Project StatusSpo11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016682 VEGA Gene Model | MGI Sequence Detail 15877 C57BL/6J ±  kb
transcript OTTMUST00000040396 VEGA | MGI Sequence Detail 1709 Not Applicable 
polypeptide OTTMUSP00000018047 VEGA | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(20) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(220 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004084 Meiosis-specific protein Spo11
InterPro IPR013048 Meiotic recombination, Spo11
InterPro IPR002815 Spo11/DNA topoisomerase VI, subunit A
InterPro IPR013049 Spo11/DNA topoisomerase VI, subunit A, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000015553 meiotic recombination protein SPO11
References (Earliest) J:58262 Romanienko PJ, et al., Cloning, characterization, and localization of mouse and human SPO11. Genomics. 1999 Oct 15;61(2):156-69
(Latest) J:205585 Qiao H, et al., Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet. 2014 Feb;46(2):194-9
All references(83)
Other
accession IDs
MGI:2138956

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory