Spo11 MGI Mouse Gene Detail - MGI:1349669 - SPO11 meiotic protein covalently bound to DSB

Symbol

Spo11
Name

SPO11 meiotic protein covalently bound to DSB
Synonyms

Spo11a, Spo11b

Feature Type

protein coding gene
IDs

MGI:1349669
NCBI Gene: 26972
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:172977700-172993576 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 95.64 cM, cytoband H4
Mapping Data

5 experiments

SNPs within 2kb

221 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349669	protein coding gene	Chr2:172977227-172993576 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026950	protein coding gene	Chr2:179216876-179234530 (+)
A/J	MGP_AJ_G0026917	protein coding gene	Chr2:171684655-171700532 (+)
AKR/J	MGP_AKRJ_G0026888	protein coding gene	Chr2:176858847-176877746 (+)
BALB/cJ	MGP_BALBcJ_G0026926	protein coding gene	Chr2:172084539-172100744 (+)
C3H/HeJ	MGP_C3HHeJ_G0026668	protein coding gene	Chr2:177242280-177258148 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027373	protein coding gene	Chr2:184371378-184388638 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024743	protein coding gene	Chr2:164926283-164941557 (+)
CAST/EiJ	MGP_CASTEiJ_G0026126	protein coding gene	Chr2:177939382-177956687 (+)
CBA/J	MGP_CBAJ_G0026645	protein coding gene	Chr2:191278053-191293962 (+)
DBA/2J	MGP_DBA2J_G0026783	protein coding gene	Chr2:170781698-170797595 (+)
FVB/NJ	MGP_FVBNJ_G0026749	protein coding gene	Chr2:169399045-169415048 (+)
LP/J	MGP_LPJ_G0026884	protein coding gene	Chr2:179154985-179172263 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026768	protein coding gene	Chr2:194222234-194238066 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027430	protein coding gene	Chr2:176872998-176888697 (+)
PWK/PhJ	MGP_PWKPhJ_G0025863	protein coding gene	Chr2:170573470-170589495 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025663	protein coding gene	Chr2:175864870-175882914 (+)
WSB/EiJ	MGP_WSBEiJ_G0026199	protein coding gene	Chr2:177830068-177845738 (+)

Human Ortholog

SPO11, SPO11 initiator of meiotic double stranded breaks

Vertebrate Orthologs

9

Human Ortholog

SPO11, SPO11 initiator of meiotic double stranded breaks
Orthology source: HomoloGene, HGNC
Synonyms

CT35, SPATA43, TOPVIA
Links

HGNC:11250

NCBI Gene ID: 23626

neXtProt AC: NX_Q9Y5K1

UniProt: Q9Y5K1
Chr Location

20q13.31; chr20:57329757-57343993 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 6059
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: SPO11
Gene Tree

Spo11

less

Phenotype Summary

37 phenotypes from 8 alleles in 11 genetic backgrounds
15 phenotypes from multigenic genotypes
4 images
74 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Targeted

12
Incidental Mutations

APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation are sterile. Mutant males exhibit loss of spermatocytes in early prophase, while mutant females exhibit oocyte loss soon after birth.

less

All GO Annotations

31
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

102
Tissues

21
cDNA Data

12
Literature Summary

25

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spo11

ZFIN spo11

less

Spo11 interacts with 62 markers (Mir19a, Mir25, Mir27a, ...) View All

less

All Sequences

69
RefSeq

20
UniProt

2
CCDS

CCDS17137.1, CCDS50811.1, CCDS50812.1
UniGene

23495

Ensembl

ENSMUSG00000005883 (Evidence)
NCBI Gene

26972

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005883	Ensembl Gene Model \| MGI Sequence Detail	15877	C57BL/6J	± kb
transcript	ENSMUST00000050442	Ensembl \| MGI Sequence Detail	1709	Not Applicable
polypeptide	ENSMUSP00000059056	Ensembl \| MGI Sequence Detail	396	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000015553 meiotic recombination protein SPO11

(term hierarchy)
EC

5.6.2.2
InterPro Domains

IPR004084 Meiosis-specific protein Spo11

IPR013048 Meiotic recombination, Spo11

IPR002815 Spo11/DNA topoisomerase VI subunit A

IPR013049 Spo11/DNA topoisomerase VI, subunit A, N-terminal

IPR036078 Spo11/DNA topoisomerase VI subunit A superfamily

IPR034136 Topoisomerase 6 subunit A/Spo11, TOPRIM domain

IPR036388 Winged helix-like DNA-binding domain superfamily

less

All nucleic 21

Genomic 2

cDNA 12

Primer pair 6

Other 1

Microarray probesets 3

less

MGI:2138956

Summaries

All 119

Developmental Gene Expression 25

Gene Ontology 14

Phenotypes 74
Earliest

J:58262 Romanienko PJ, et al., Cloning, characterization, and localization of mouse and human SPO11. Genomics. 1999 Oct 15;61(2):156-69
Latest

J:273173 Zhang J, et al., A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. Nat Commun. 2019 Feb 13;10(1):722

TSS for Spo11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21978	Chr2:172977553-172977558 (+)	-144 bp
Tssr21979	Chr2:172977625-172977632 (+)	-71 bp
Tssr21980	Chr2:172977653-172977676 (+)	-35 bp
Tssr21981	Chr2:172977682-172977695 (+)	-11 bp
Tssr21982	Chr2:172977700-172977711 (+)	6 bp
Tssr21983	Chr2:172977731-172977751 (+)	41 bp
Tssr21984	Chr2:172977758-172977789 (+)	74 bp
Tssr21985	Chr2:172977852-172977863 (+)	158 bp
Tssr21986	Chr2:172977875-172977901 (+)	188 bp
Tssr21987	Chr2:172977908-172977922 (+)	215 bp
Tssr21988	Chr2:172979827-172979879 (+)	2,153 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14