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Pla2g2e Gene Detail
Summary
  • Symbol
    Pla2g2e
  • Name
    phospholipase A2, group IIE
  • Synonyms
    mGIIEsPLA2s
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349660
    NCBI Gene: 26970
Location & Maps
more
  • Sequence Map
    Chr4:138877942-138882817 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4876 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PLA2G2E, phospholipase A2 group IIE
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PLA2G2E, phospholipase A2 group IIE
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GIIE sPLA2, sPLA2-IIE
  • Links
    NCBI Gene ID: 30814
    neXtProt AC: NX_Q9NZK7

  • Chr Location
    1p36.13; chr1:19920307-19923617 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    7
  • Genomic Mutations
    3 involving Pla2g2e
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit normal IgE antigen-dependent passive cutaneous anaphylaxis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010067 VEGA Gene Model | MGI Sequence Detail 4876 C57BL/6J ±  kb
transcript OTTMUST00000023404 VEGA | MGI Sequence Detail 854 Not Applicable  
polypeptide OTTMUSP00000010699 VEGA | MGI Sequence Detail 142 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    103 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 6
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 34
    Developmental Gene Expression 6
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
  • Latest
    J:232433 Murase R, et al., Group X Secreted Phospholipase A2 Releases omega3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016 Mar 25;291(13):6895-911

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory