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Cul1 Gene Detail
Summary
  • Symbol
    Cul1
  • Name
    cullin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349658
    NCBI Gene: 26965
  • Gene Overview
    MyGene.info: CUL1
Location & Maps
more
  • Sequence Map
    Chr6:47453398-47526139 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      72742 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 22.90 cM, cytoband B3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CUL1, cullin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CUL1, cullin 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 8454
    neXtProt AC: NX_Q13616

  • Chr Location
    7q36.1; chr7:148698178-148801110 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2663
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CUL1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    68
  • Gene trapped
    65
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for targeted null mutations accumulate cyclin E1 and exhibit arrested development and lethality around embryonic day 6.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022333 VEGA Gene Model | MGI Sequence Detail 72742 C57BL/6J ±  kb
transcript OTTMUST00000053240 VEGA | MGI Sequence Detail 3161 Not Applicable  
polypeptide OTTMUSP00000025305 VEGA | MGI Sequence Detail 776 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    211 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
References
more
  • Summaries
    All 43
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:57767 Dealy MJ, et al., Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat Genet. 1999 Oct;23(2):245-8
  • Latest
    J:226978 Tateossian H, et al., Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech. 2015 Dec 1;8(12):1531-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory