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Cul1
Gene Detail
Symbol

Name
ID
Cul1
cullin 1
MGI:1349658
Feature Type
protein coding gene
Genetic Map
Chromosome 6
22.90 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:47453398-47526139 bp, + strand
From VEGA annotation of GRCm38

  72742 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2663  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cullin
Gene Tree: Cul1

Human
homologs
Human Homolog CUL1, cullin 1
NCBI Gene ID 8454
neXtProt AC  NX_Q13616
Human Chr (Location)  7q36.1; chr7:148698654-148801110 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(65) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations accumulate cyclin E1 and exhibit arrested development and lethality around embryonic day 6.5.
 
Interactions
Cul1 interacts with 200 markers (Mir1b, Mir7-1, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (63)    Tissues (28)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 63
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022333 (Evidence)
Ensembl Gene ModelENSMUSG00000029686 (Evidence)
Entrez Gene26965 (Evidence)
DFCITC1573247, TC1711066, TC1595070
DoTSDT.40152952, DT.110486259, DT.535670, DT.94411079, DT.91382330
NIA Mouse Gene IndexU006809
Consensus CDS ProjectCCDS20095.1
International Mouse Knockout Project StatusCul1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022333 VEGA Gene Model | MGI Sequence Detail 72742 C57BL/6J ±  kb
transcript OTTMUST00000053240 VEGA | MGI Sequence Detail 3161 Not Applicable 
polypeptide OTTMUSP00000025305 VEGA | MGI Sequence Detail 776 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(8) UniProt(11)
Polymorphisms
SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016157 Cullin, conserved site
InterPro IPR016158 Cullin homology
InterPro IPR001373 Cullin, N-terminal
InterPro IPR019559 Cullin protein, neddylation domain
InterPro IPR016159 Cullin repeat-like-containing domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000000092 fungal/metazoan cullin-1
References
(Earliest) J:57767 Dealy MJ, et al., Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. Nat Genet. 1999 Oct;23(2):245-8
(Latest) J:205916 Yumimoto K, et al., Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. J Biol Chem. 2013 Nov 8;288(45):32766-76
All references(47)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory