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Sec23a Gene Detail
Summary
  • Symbol
    Sec23a
  • Name
    SEC23 homolog A, COPII coat complex component
  • Synonyms
    Msec23, Sec23r
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349635
    NCBI Gene: 20334
  • Gene Overview
    MyGene.info: SEC23A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:58958383-59012017 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 25.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    610 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349635
protein coding gene Chr12:58958383-59012027 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019765
protein coding gene Chr12:58150136-58205859 (-)
A/J MGP_AJ_G0019724
protein coding gene Chr12:56038039-56093253 (-)
AKR/J MGP_AKRJ_G0019699
protein coding gene Chr12:57816477-57875204 (-)
BALB/cJ MGP_BALBcJ_G0019704
protein coding gene Chr12:56420436-56474491 (-)
C3H/HeJ MGP_C3HHeJ_G0019509
protein coding gene Chr12:57918058-57973753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020156
protein coding gene Chr12:59855881-59911423 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017776
protein coding gene Chr12:54413888-54466062 (-)
CAST/EiJ MGP_CASTEiJ_G0019061
protein coding gene Chr12:52807719-52862483 (-)
CBA/J MGP_CBAJ_G0019478
protein coding gene Chr12:62055527-62121762 (-)
DBA/2J MGP_DBA2J_G0019594
protein coding gene Chr12:55954659-56007937 (-)
FVB/NJ MGP_FVBNJ_G0019582
protein coding gene Chr12:55220197-55278052 (-)
LP/J MGP_LPJ_G0019666
protein coding gene Chr12:58189599-58246638 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019620
protein coding gene Chr12:63668946-63727509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020190
protein coding gene Chr12:57263668-57318966 (-)
PWK/PhJ MGP_PWKPhJ_G0018828
protein coding gene Chr12:50317824-50373571 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018621
protein coding gene Chr12:51666863-51719804 (-)
WSB/EiJ MGP_WSBEiJ_G0019112
protein coding gene Chr12:57828630-57885540 (-)



Homology
more
  • Human Ortholog
    SEC23A, Sec23 homolog A, coat complex II component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC23A, Sec23 homolog A, coat complex II component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLSD, hSec23A
  • Links
    NCBI Gene ID: 10484
    neXtProt AC: NX_Q15436
    UniProt: Q15436

  • Chr Location
    14q21.1; chr14:39031919-39103528 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SEC23A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die during mid-embryogenesis exhibiting defects in neural tube closure and extraembryonic membrane formation as well as broad secretion defects of multiple collagen species in different tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020986 Ensembl Gene Model | MGI Sequence Detail 53635 C57BL/6J ±  kb
    transcript ENSMUST00000021375 Ensembl | MGI Sequence Detail 4109 Not Applicable  
    polypeptide ENSMUSP00000021375 Ensembl | MGI Sequence Detail 765 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 8
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14354, MGI:98275
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 10
    • Earliest
      J:3745 Carding SR, et al., Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. J Exp Med. 1993 Feb 1;177(2):475-82
    • Latest
      J:244983 Schultz NG, et al., The Genetic Basis of Baculum Size and Shape Variation in Mice. G3 (Bethesda). 2016 May 03;6(5):1141-51

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory