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Sec23a Gene Detail
Summary
  • Symbol
    Sec23a
  • Name
    SEC23 homolog A, COPII coat complex component
  • Synonyms
    Msec23, Sec23r
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349635
    NCBI Gene: 20334
  • Gene Overview
    MyGene.info: SEC23A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:58958383-59012017 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      53635 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 25.97 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SEC23A, Sec23 homolog A, coat complex II component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC23A, Sec23 homolog A, coat complex II component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CLSD, hSec23A
  • Links
    NCBI Gene ID: 10484
    neXtProt AC: NX_Q15436
    UniProt: Q15436

  • Chr Location
    14q21.1; chr14:39031919-39103528 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die during mid-embryogenesis exhibiting defects in neural tube closure and extraembryonic membrane formation as well as broad secretion defects of multiple collagen species in different tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026430 VEGA Gene Model | MGI Sequence Detail 53635 C57BL/6J ±  kb
    transcript OTTMUST00000065364 VEGA | MGI Sequence Detail 4109 Not Applicable  
    polypeptide OTTMUSP00000032571 VEGA | MGI Sequence Detail 765 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      610 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 6
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14354, MGI:98275
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:3745 Carding SR, et al., Activation of cytokine genes in T cells during primary and secondary murine influenza pneumonia. J Exp Med. 1993 Feb 1;177(2):475-82
    • Latest
      J:244983 Schultz NG, et al., The Genetic Basis of Baculum Size and Shape Variation in Mice. G3 (Bethesda). 2016 May 03;6(5):1141-51

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory