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Ing1
Gene Detail
Symbol

Name
ID
Ing1
inhibitor of growth family, member 1
MGI:1349481
Synonyms
2610028J21Rik, mING1h, p33Ing1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:11556066-11563250 bp, + strand
From NCBI annotation of GRCm38

  7185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: uncharacterized conserved protein
Gene Tree: Ing1

Human
homologs
Human Homolog ING1, inhibitor of growth family, member 1
NCBI Gene ID 3621
neXtProt AC  NX_Q9UK53
Human Synonyms  p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
Human Chr (Location)  13q34; chr13:110712623-110721074 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ING1
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(14) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display a slight decrease in body weight, moderately impaired maternal nurturing, increased sensitivity to gamma-irradiation, and increased incidence of B-cell derived lymphomas.
 
Interactions
Ing1 interacts with 172 markers (Mir15a, Mir15b, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell cycle, chromatin modification, ...
Component nucleus
Function metal ion binding, methylated histone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (61)    Tissues (57)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
RT-PCR 16
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000045969 (Evidence)
Entrez Gene26356 (Evidence)
DFCITC1575017
DoTSDT.101376699, DT.101703112, DT.535847, DT.91595280, DT.97338824
NIA Mouse Gene IndexU009076
Consensus CDS ProjectCCDS22097.1
International Mouse Knockout Project StatusIng1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26356 NCBI Gene Model | MGI Sequence Detail 7185 C57BL/6J ±  kb
transcript NM_011919 RefSeq | MGI Sequence Detail 2813 C57BL/6 
polypeptide Q9QXV3 UniProt | EBI | MGI Sequence Detail 279 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024610 Inhibitor of growth protein, N-terminal
InterPro IPR011011 Zinc finger, FYVE/PHD-type
InterPro IPR019787 Zinc finger, PHD-finger
InterPro IPR001965 Zinc finger, PHD-type
InterPro IPR019786 Zinc finger, PHD-type, conserved site
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
Protein Ontology PR:000009033 inhibitor of growth protein 1
Graphical View of Protein Domain Structure
References
(Earliest) J:39291 Helbing CC, et al., A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis. Cancer Res. 1997 Apr 1;57(7):1255-8
(Latest) J:194911 Rajarajacholan UK, et al., The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. PLoS Biol. 2013 Mar;11(3):e1001502
All references(50)
Other
accession IDs
MGI:1916494, MGI:2142397, MGI:2144914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory