Ing1
Gene Detail

Symbol Name ID

Ing1 inhibitor of growth family, member 1 MGI:1349481

Synonyms

2610028J21Rik, mING1h, p33Ing1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:11556066-11563250 bp, + strand From NCBI annotation of GRCm38   7185 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40119  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: uncharacterized conserved protein
Gene Tree: Ing1

Human homologs

Human Homolog		ING1, inhibitor of growth family, member 1
NCBI Gene ID		3621
neXtProt AC		NX_Q9UK53
Human Synonyms		p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
Human Chr (Location)		13q34; chr13:111364970-111373421 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ING1

Alleles and phenotypes

All alleles(17) : Targeted(3) Gene trapped(14)
 

Homozygous null mice display a slight decrease in body weight, moderately impaired maternal nurturing, increased sensitivity to gamma-irradiation, and increased incidence of B-cell derived lymphomas.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cell cycle, positive regulation of transcription, DNA-dependent, ...
Component	nucleus
Function	metal ion binding, methylated histone residue binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (74)    Tissues (66)    Images (4)
Theiler Stages: 1, 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	44
RT-PCR	30

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000045969 (Evidence)
Entrez Gene	26356 (Evidence)
DFCI	TC1575017
DoTS	DT.101376699, DT.101703112, DT.535847, DT.91595280, DT.97338824
NIA Mouse Gene Index	U009076
Consensus CDS Project	CCDS22097.1
International Mouse Knockout Project Status	Ing1

Sequences

Length	Strain/Species
genomic	26356	NCBI Gene Model | MGI Sequence Detail	7185	C57BL/6J
transcript	NM_011919	RefSeq | MGI Sequence Detail	2813	C57BL/6
polypeptide	Q9QXV3	UniProt | EBI | MGI Sequence Detail	279	Not Applicable

All sequences(40) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024610	Inhibitor of growth protein, N-terminal
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019787	Zinc finger, PHD-finger
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000009033	inhibitor of growth protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:39291 Helbing CC, et al., A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis. Cancer Res. 1997 Apr 1;57(7):1255-8
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(48)

Other accession IDs

MGI:1916494, MGI:2142397, MGI:2144914