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Ing1 Gene Detail
Summary
  • Symbol
    Ing1
  • Name
    inhibitor of growth family, member 1
  • Synonyms
    2610028J21Rik, mING1h, p33Ing1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349481
    NCBI Gene: 26356
  • Gene Overview
    MyGene.info: ING1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:11555571-11563251 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7681 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ING1, inhibitor of growth family member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ING1, inhibitor of growth family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p24ING1c, p33, p33ING1, p33ING1b, p47, p47ING1a
  • Links
    NCBI Gene ID: 3621
    neXtProt AC: NX_Q9UK53
    UniProt: Q9UK53

  • Chr Location
    13q34; chr13:110712623-110721074 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ING1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display a slight decrease in body weight, moderately impaired maternal nurturing, increased sensitivity to gamma-irradiation, and increased incidence of B-cell derived lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060767 VEGA Gene Model | MGI Sequence Detail 7681 C57BL/6J ±  kb
    transcript OTTMUST00000148559 VEGA | MGI Sequence Detail 2814 Not Applicable  
    polypeptide OTTMUSP00000077207 VEGA | MGI Sequence Detail 279 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      82 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916494, MGI:2142397, MGI:2144914
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:39291 Helbing CC, et al., A novel candidate tumor suppressor, ING1, is involved in the regulation of apoptosis. Cancer Res. 1997 Apr 1;57(7):1255-8
    • Latest
      J:194911 Rajarajacholan UK, et al., The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway. PLoS Biol. 2013 Mar;11(3):e1001502

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory