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Scamp1 Gene Detail
Summary
  • Symbol
    Scamp1
  • Name
    secretory carrier membrane protein 1
  • Synonyms
    4930505M11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349480
    NCBI Gene: 107767
  • Gene Overview
    MyGene.info: SCAMP1
Location & Maps
more
  • Sequence Map
    Chr13:94201310-94285857 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      84548 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 49.22 cM, cytoband D1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SCAMP1, secretory carrier membrane protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SCAMP1, secretory carrier membrane protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCAMP, SCAMP37
  • Links
    NCBI Gene ID: 9522
    neXtProt AC: NX_O15126

  • Chr Location
    5q14.1; chr5:78360503-78480739 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    3
  • Genomic Mutations
    1 involving Scamp1
  • Incidental Mutations
Mice homozygous for a targeted null mutation do not exhibit any overt abnormalities, but final cell capacitance of mast cells completing exocytosis was smaller than controls and an increased proportion of reversible fusion events was noted.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033839 VEGA Gene Model | MGI Sequence Detail 84548 C57BL/6J ±  kb
transcript OTTMUST00000085257 VEGA | MGI Sequence Detail 4259 Not Applicable  
polypeptide OTTMUSP00000046039 VEGA | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    400 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014483 secretory carrier-associated membrane protein 1
  • InterPro Domains
    IPR007273 SCAMP
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
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MGI:1922292, MGI:2145229, MGI:2145416
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:58332 Fernandez-Chacon R, et al., Analysis of SCAMP1 function in secretory vesicle exocytosis by means of gene targeting in mice. J Biol Chem. 1999 Nov 12;274(46):32551-4
  • Latest
    J:140969 Felkl M, et al., Interaction assays in yeast and cultured cells confirm known and identify novel partners of the synaptic vesicle protein synaptophysin. Neuroscience. 2008 Oct 2;156(2):344-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory