Chst4
Gene Detail

Symbol Name ID

Chst4 carbohydrate (chondroitin 6/keratan) sulfotransferase 4 MGI:1349479

Synonyms

GST-3, HEC-GlcNAc6ST, high endothelial cell GlcNAC-6-sulphotransferase

Feature Type

protein coding gene

Genetic Map

Chromosome 8

57.38 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:110029075-110039334 bp, - strand From NCBI annotation of GRCm38   10260 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4216  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst4

Human homologs

Human Homolog		CHST4, carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
NCBI Gene ID		10164
neXtProt AC		NX_Q8NCG5
Human Synonyms		GlcNAc6ST2, GST3, HECGLCNAC6ST, LSST
Human Chr (Location)		16q22.2; chr16:71560023-71572493 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruptions in this gene do not accumulate lymphocytes in peripheral lymph nodes to as great an extent as normal. The animals are phenotypically normal otherwise.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	carbohydrate metabolic process, inflammatory response, ...
Component	Golgi apparatus, Golgi membrane, ...
Function	N-acetylglucosamine 6-O-sulfotransferase activity, sulfotransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (105)    Tissues (105)    Images (4)
Theiler Stages: 18, 22, 25, 28

Assay Type	Results
RNA in situ	95
Northern blot	8
RT-PCR	2

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000035930 (Evidence)
Entrez Gene	26887 (Evidence)
UniGene	89207
DFCI	TC1587487, TC1614793, TC1756536
DoTS	DT.527542, DT.91335844
NIA Mouse Gene Index	U030242
EC	2.8.2.-
Consensus CDS Project	CCDS22659.1
International Mouse Knockout Project Status	Chst4

Sequences

Length	Strain/Species
genomic	26887	NCBI Gene Model | MGI Sequence Detail	10260	C57BL/6J
transcript	NM_011998	RefSeq | MGI Sequence Detail	2000	C57BL/6
polypeptide	Q9R1I1	UniProt | EBI | MGI Sequence Detail	388	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016469	Carbohydrate sulfotransferase
InterPro	IPR000863	Sulfotransferase domain
Protein Ontology	PR:000005477	carbohydrate sulfotransferase 4

Graphical View of Protein Domain Structure

References

(Earliest) J:57381 Hiraoka N, et al., A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34. Immunity. 1999 Jul;11(1):79-89
(Latest) J:177302 Ohmichi Y, et al., Essential role of peripheral node addressin in lymphocyte homing to nasal-associated lymphoid tissues and allergic immune responses. J Exp Med. 2011 May 9;208(5):1015-25
All references(37)