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Chst4 Gene Detail
Summary
  • Symbol
    Chst4
  • Name
    carbohydrate (chondroitin 6/keratan) sulfotransferase 4
  • Synonyms
    GST-3, HEC-GlcNAc6ST, high endothelial cell GlcNAC-6-sulphotransferase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349479
    NCBI Gene: 26887
  • Gene Overview
    MyGene.info: CHST4
Location & Maps
more
  • Sequence Map
    Chr8:110029075-110039334 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10260 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 57.38 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CHST4, carbohydrate sulfotransferase 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CHST4, carbohydrate sulfotransferase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GlcNAc6ST2, GST3, HECGLCNAC6ST, LSST
  • Links
    NCBI Gene ID: 10164
    neXtProt AC: NX_Q8NCG5

  • Chr Location
    16q22.2; chr16:71526120-71538590 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene do not accumulate lymphocytes in peripheral lymph nodes to as great an extent as normal. The animals are phenotypically normal otherwise.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035930 Ensembl Gene Model | MGI Sequence Detail 10260 C57BL/6J ±  kb
transcript ENSMUST00000109222 Ensembl | MGI Sequence Detail 2000 Not Applicable  
polypeptide ENSMUSP00000104845 Ensembl | MGI Sequence Detail 388 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    78 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR016469 Carbohydrate sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000863 Sulfotransferase domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:57381 Hiraoka N, et al., A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34. Immunity. 1999 Jul;11(1):79-89
  • Latest
    J:204813 Patnode ML, et al., KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar;23(3):381-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory