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Chst4
Gene Detail
 Symbol
Name
ID
Chst4
carbohydrate (chondroitin 6/keratan) sulfotransferase 4
MGI:1349479
Synonyms GST-3, HEC-GlcNAc6ST, high endothelial cell GlcNAC-6-sulphotransferase
Feature Type protein coding gene
Genetic Map
Chromosome 8
57.38 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:110029075-110039334 bp, - strand
From NCBI annotation of GRCm38

  10260 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4216  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: carbohydrate sulfotransferase
Gene Tree: Chst4

Human
homologs
Human Homolog CHST4, carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
NCBI Gene ID 10164
neXtProt AC  NX_Q8NCG5
Human Synonyms  GlcNAc6ST2, GST3, HECGLCNAC6ST, LSST
Human Chr (Location)  16q22.2; chr16:71526120-71538590 (+)  GRCh38
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene do not accumulate lymphocytes in peripheral lymph nodes to as great an extent as normal. The animals are phenotypically normal otherwise.
 
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process carbohydrate metabolic process, inflammatory response, ...
Component Golgi apparatus, Golgi membrane, ...
Function 1-hydroxypyrene sulfotransferase activity, 1-phenanthrol sulfotransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (105)    Tissues (105)    Images (4)
Theiler Stages: 18, 22, 25, 28
Assay TypeResults
RNA in situ 95
Northern blot 8
RT-PCR 2
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035930 (Evidence)
Entrez Gene26887 (Evidence)
UniGene89207
DFCITC1587487, TC1614793, TC1756536
DoTSDT.527542, DT.91335844
NIA Mouse Gene IndexU030242
EC2.8.2.-
Consensus CDS ProjectCCDS22659.1
International Mouse Knockout Project StatusChst4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 26887 NCBI Gene Model | MGI Sequence Detail 10260 C57BL/6J ±  kb
transcript NM_011998 RefSeq | MGI Sequence Detail 2000 C57BL/6 
polypeptide Q9R1I1 UniProt | EBI | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016469 Carbohydrate sulfotransferase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000863 Sulfotransferase domain
Protein Ontology PR:000005477 carbohydrate sulfotransferase 4
Graphical View of Protein Domain Structure
References (Earliest) J:57381 Hiraoka N, et al., A novel, high endothelial venule-specific sulfotransferase expresses 6-sulfo sialyl Lewis(x), an L-selectin ligand displayed by CD34. Immunity. 1999 Jul;11(1):79-89
(Latest) J:204813 Patnode ML, et al., KSGal6ST generates galactose-6-O-sulfate in high endothelial venules but does not contribute to L-selectin-dependent lymphocyte homing. Glycobiology. 2013 Mar;23(3):381-94
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory