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Trpc7 Gene Detail
Summary
  • Symbol
    Trpc7
  • Name
    transient receptor potential cation channel, subfamily C, member 7
  • Synonyms
    TRP7, Trrp8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349470
    NCBI Gene: 26946
  • Gene Overview
    MyGene.info: TRPC7
Location & Maps
more
  • Sequence Map
    Chr13:56773113-56895789 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      122677 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 30.27 cM, cytoband B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TRPC7, transient receptor potential cation channel subfamily C member 7
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TRPC7, transient receptor potential cation channel subfamily C member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TRP7
  • Links
    NCBI Gene ID: 57113
    neXtProt AC: NX_Q9HCX4

  • Chr Location
    5q31.1; chr5:136212765-136365476 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Trpc7
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal eye physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024552 VEGA Gene Model | MGI Sequence Detail 122677 C57BL/6J ±  kb
transcript OTTMUST00000060302 VEGA | MGI Sequence Detail 3483 Not Applicable  
polypeptide OTTMUSP00000029406 VEGA | MGI Sequence Detail 862 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1455 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000001080 transient receptor potential cation channel TRPC7
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR005821 Ion transport domain
    IPR013555 Transient receptor ion channel domain
    IPR004729 Transient receptor potential channel
    IPR002153 Transient receptor potential channel, canonical
    IPR005463 Transient receptor potential channel, canonical 7
Molecular
Reagents
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  • All nucleic 9
    cDNA 6
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:57770 Okada T, et al., Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70
  • Latest
    J:218743 Lutas A, et al., Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory