Trpc7
Gene Detail

Symbol Name ID

Trpc7 transient receptor potential cation channel, subfamily C, member 7 MGI:1349470

Synonyms

TRP7, Trrp8

Feature Type

protein coding gene

Genetic Map

Chromosome 13

30.27 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:56773113-56895789 bp, - strand From VEGA annotation of GRCm38   122677 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc7

Human homologs

Human Homolog		TRPC7, transient receptor potential cation channel, subfamily C, member 7
NCBI Gene ID		57113
neXtProt AC		NX_Q9HCX4
Human Synonyms		TRP7
Human Chr (Location)		5q31.1; chr5:135548999-135701164 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit abnormal eye physiology.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	cis-Golgi network, integral to membrane, ...
Function	calcium channel activity, ion channel activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (31)    Tissues (13)    Images (4)
Theiler Stages: 17, 19, 20, 22, 25, 26, 28

Assay Type	Results
RNA in situ	2
RT-PCR	29

cDNA source data(6)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(6) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000024552 (Evidence)
Ensembl Gene Model	ENSMUSG00000021541 (Evidence)
Entrez Gene	26946 (Evidence)
UniGene	62409
DFCI	TC1591010
DoTS	DT.110977707, DT.55244871
NIA Mouse Gene Index	U034835
Consensus CDS Project	CCDS26566.1
International Mouse Knockout Project Status	Trpc7

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024552	VEGA Gene Model | MGI Sequence Detail	122677	C57BL/6J
transcript	OTTMUST00000060302	VEGA | MGI Sequence Detail	3483	Not Applicable
polypeptide	OTTMUSP00000029406	VEGA | MGI Sequence Detail	862	Not Applicable

All sequences(56) RefSeq(2) UniProt(10)

Polymorphisms

SNPs(1045 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR005821	Ion transport domain
InterPro	IPR013555	Transient receptor ion channel domain
InterPro	IPR004729	Transient receptor potential channel
InterPro	IPR002153	Transient receptor potential channel, canonical
InterPro	IPR005463	Transient receptor potential channel, canonical 7
Protein Ontology	PR:000001080	transient receptor potential cation channel TRPC7

References

(Earliest) J:57770 Okada T, et al., Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70
(Latest) J:176849 Perez-Leighton CE, et al., Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits. Eur J Neurosci. 2011 Mar;33(5):856-67
All references(39)