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Trpc7
Gene Detail
Symbol

Name
ID
Trpc7
transient receptor potential cation channel, subfamily C, member 7
MGI:1349470
Synonyms
TRP7, Trrp8
Feature Type
protein coding gene
Genetic Map
Chromosome 13
30.27 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:56773113-56895789 bp, - strand
From VEGA annotation of GRCm38

  122677 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22689  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: TRPC7
Protein SuperFamily: transient receptor potential cation channel, subfamily C
Gene Tree: Trpc7

Human
homologs
TRPC7, transient receptor potential cation channel, subfamily C, member 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 57113
neXtProt AC: NX_Q9HCX4

Human Synonyms: TRP7

Human Chr (Location): 5q31.1; chr5:136212765-136365476 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal eye physiology.
 
Interactions
Trpc7 interacts with 294 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component cis-Golgi network, cytosol, ...
Function calcium channel activity, inositol 1,4,5 trisphosphate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (80)    Tissues (65)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 51
RT-PCR 29
cDNA source data(6)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN trpc7a, trpc7b    NEW 
Molecular
reagents
All nucleic(9) cDNA(6) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000024552 (Evidence)
Ensembl Gene Model ENSMUSG00000021541 (Evidence)
Entrez Gene 26946 (Evidence)
UniGene 62409
DFCI TC1591010
DoTS DT.55244871, DT.110977707
NIA Mouse Gene Index U034835
Consensus CDS Project CCDS26566.1
International Mouse Phenotyping Consortium Status Trpc7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024552 VEGA Gene Model | MGI Sequence Detail 122677 C57BL/6J ±  kb
transcript OTTMUST00000060302 VEGA | MGI Sequence Detail 3483 Not Applicable 
polypeptide OTTMUSP00000029406 VEGA | MGI Sequence Detail 862 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(14) UniProt(10)
Polymorphisms
SNPs within 2kb(1462 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1466)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR005821 Ion transport domain
InterPro IPR013555 Transient receptor ion channel domain
InterPro IPR004729 Transient receptor potential channel
InterPro IPR002153 Transient receptor potential channel, canonical
InterPro IPR005463 Transient receptor potential channel, canonical 7
Protein Ontology PR:000001080 transient receptor potential cation channel TRPC7
References
(Earliest) J:57770 Okada T, et al., Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem. 1999 Sep 24;274(39):27359-70
(Latest) J:218743 Lutas A, et al., Metabolism regulates the spontaneous firing of substantia nigra pars reticulata neurons via KATP and nonselective cation channels. J Neurosci. 2014 Dec 3;34(49):16336-47
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory