Uba7 MGI Mouse Gene Detail - MGI:1349462 - ubiquitin-like modifier activating enzyme 7

Symbol

Uba7
Name

ubiquitin-like modifier activating enzyme 7
Synonyms

1300004C08Rik, Ube1l

Feature Type

protein coding gene
IDs

MGI:1349462
NCBI Gene: 74153
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:107852766-107861255 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.07 cM
Mapping Data

2 experiments

SNPs within 2kb

47 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349462	protein coding gene	Chr9:107852704-107861259 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035276	protein coding gene	Chr9:109890440-109898996 (+)
A/J	MGP_AJ_G0035255	protein coding gene	Chr9:105879572-105888127 (+)
AKR/J	MGP_AKRJ_G0035187	protein coding gene	Chr9:108520482-108529038 (+)
BALB/cJ	MGP_BALBcJ_G0035249	protein coding gene	Chr9:105549953-105558508 (+)
C3H/HeJ	MGP_C3HHeJ_G0034959	protein coding gene	Chr9:108918027-108926582 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035769	protein coding gene	Chr9:112863333-112871888 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032667	protein coding gene	Chr9:103312859-103321476 (+)
CAST/EiJ	MGP_CASTEiJ_G0034270	protein coding gene	Chr9:108875434-108883988 (+)
CBA/J	MGP_CBAJ_G0034927	protein coding gene	Chr9:116862094-116870631 (+)
DBA/2J	MGP_DBA2J_G0035088	protein coding gene	Chr9:105335567-105344123 (+)
FVB/NJ	MGP_FVBNJ_G0035036	protein coding gene	Chr9:104100386-104108941 (+)
LP/J	MGP_LPJ_G0035164	protein coding gene	Chr9:110085950-110094506 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035075	protein coding gene	Chr9:118454738-118463293 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035790	protein coding gene	Chr9:108797896-108806452 (+)
PWK/PhJ	MGP_PWKPhJ_G0033977	protein coding gene	Chr9:105656267-105664858 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033812	protein coding gene	Chr9:108859702-108870677 (+)
WSB/EiJ	MGP_WSBEiJ_G0034391	protein coding gene	Chr9:108678236-108686792 (+)

Human Ortholog

UBA7, ubiquitin like modifier activating enzyme 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBA7, ubiquitin like modifier activating enzyme 7
Synonyms

D8, UBA1B, UBE1L, UBE2, UBE7
Links

HGNC:12471

NCBI Gene ID: 7318

neXtProt AC: NX_P41226

UniProt: P41226
Chr Location

3p21.31; chr3:49805209-49813953 (-) GRCh38

MGI Vertebrate Homology

Uba7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBA7
Gene Tree

Uba7

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
16 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Homozygous null mice lacking ISG15 conjugation but not free ISG15 are healthy and fertile and exhibit normal antiviral responses against vesicular stomatitis virus and lymphocytic choriomeningitis virus infection. Bone-derived macrophages from mutant mice display normal responses to IFN treatment.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

735
Tissues

2
cDNA Data

55
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

2
UniProt

7
CCDS

CCDS40764.1

Ensembl

ENSMUSG00000032596 (Evidence)
NCBI Gene

74153

			Length	Strain/Species	Flank
genomic	74153	NCBI Gene Model \| MGI Sequence Detail	8490	C57BL/6J	± kb
transcript	NM_023738	RefSeq \| MGI Sequence Detail	3162	C57BL/6
polypeptide	Q9DBK7	UniProt \| EBI \| MGI Sequence Detail	977	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016956 ubiquitin-like modifier-activating enzyme 7

(term hierarchy)
EC

6.2.1.-
InterPro Domains

IPR045886 ThiF/MoeB/HesA family

IPR000594 THIF-type NAD/FAD binding fold

IPR035985 Ubiquitin-activating enzyme

IPR018075 Ubiquitin-activating enzyme E1

IPR018965 Ubiquitin-activating enzyme E1, C-terminal

IPR038252 Ubiquitin-activating enzyme E1, C-terminal domain superfamily

IPR032418 Ubiquitin-activating enzyme E1, FCCH domain

IPR042302 Ubiquitin-activating enzyme E1, FCCH domain superfamily

IPR032420 Ubiquitin-activating enzyme E1, four-helix bundle

IPR042449 Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1

IPR042063 Ubiquitin-activating enzyme E1, SCCH domain

IPR019572 Ubiquitin-activating enzyme, SCCH domain

IPR000011 Ubiquitin/SUMO-activating enzyme E1-like

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All nucleic 56

Genomic 1

cDNA 55

Microarray probesets 5

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MGI:1921403

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 16
Earliest

J:57881 Persons DA, et al., Fv2 encodes a truncated form of the Stk receptor tyrosine kinase [see comments]. Nat Genet. 1999 Oct;23(2):159-65
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Uba7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87039	Chr9:107852695-107852709 (+)	-64 bp
Tssr87040	Chr9:107852728-107852800 (+)	-2 bp
Tssr87041	Chr9:107852809-107852820 (+)	49 bp
Tssr87042	Chr9:107852821-107852830 (+)	60 bp
Tssr87043	Chr9:107852842-107852847 (+)	79 bp
Tssr87044	Chr9:107852851-107852859 (+)	89 bp
Tssr87045	Chr9:107854102-107854113 (+)	1,342 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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