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Uba7 Gene Detail
Summary
  • Symbol
    Uba7
  • Name
    ubiquitin-like modifier activating enzyme 7
  • Synonyms
    1300004C08Rik, Ube1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349462
    NCBI Gene: 74153
  • Gene Overview
    MyGene.info: UBA7
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107975567-107984056 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349462
protein coding gene Chr9:107975505-107984060 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035276
protein coding gene Chr9:109890440-109898996 (+)
A/J MGP_AJ_G0035255
protein coding gene Chr9:105879572-105888127 (+)
AKR/J MGP_AKRJ_G0035187
protein coding gene Chr9:108520482-108529038 (+)
BALB/cJ MGP_BALBcJ_G0035249
protein coding gene Chr9:105549953-105558508 (+)
C3H/HeJ MGP_C3HHeJ_G0034959
protein coding gene Chr9:108918027-108926582 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035769
protein coding gene Chr9:112863333-112871888 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032667
protein coding gene Chr9:103312859-103321476 (+)
CAST/EiJ MGP_CASTEiJ_G0034270
protein coding gene Chr9:108875434-108883988 (+)
CBA/J MGP_CBAJ_G0034927
protein coding gene Chr9:116862094-116870631 (+)
DBA/2J MGP_DBA2J_G0035088
protein coding gene Chr9:105335567-105344123 (+)
FVB/NJ MGP_FVBNJ_G0035036
protein coding gene Chr9:104100386-104108941 (+)
LP/J MGP_LPJ_G0035164
protein coding gene Chr9:110085950-110094506 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035075
protein coding gene Chr9:118454738-118463293 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035790
protein coding gene Chr9:108797896-108806452 (+)
PWK/PhJ MGP_PWKPhJ_G0033977
protein coding gene Chr9:105656267-105664858 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033812
protein coding gene Chr9:108859702-108870677 (+)
WSB/EiJ MGP_WSBEiJ_G0034391
protein coding gene Chr9:108678236-108686792 (+)



Homology
more
  • Human Ortholog
    UBA7, ubiquitin like modifier activating enzyme 7
  • Vertebrate Orthologs
    7
  • Human Ortholog
    UBA7, ubiquitin like modifier activating enzyme 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D8, UBA1B, UBE1L, UBE2
  • Links
    NCBI Gene ID: 7318
    neXtProt AC: NX_P41226
    UniProt: P41226

  • Chr Location
    3p21.31; chr3:49805205-49813958 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Homozygous null mice lacking ISG15 conjugation but not free ISG15 are healthy and fertile and exhibit normal antiviral responses against vesicular stomatitis virus and lymphocytic choriomeningitis virus infection. Bone-derived macrophages from mutant mice display normal responses to IFN treatment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 74153 NCBI Gene Model | MGI Sequence Detail 8490 C57BL/6J ±  kb
transcript NM_023738 RefSeq | MGI Sequence Detail 3162 C57BL/6  
polypeptide NP_076227 RefSeq | MGI Sequence Detail 977 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR000594 THIF-type NAD/FAD binding fold
    IPR035985 Ubiquitin-activating enzyme
    IPR019572 Ubiquitin-activating enzyme, catalytic cysteine domain
    IPR018075 Ubiquitin-activating enzyme E1
    IPR018965 Ubiquitin-activating enzyme E1, C-terminal
    IPR038252 Ubiquitin-activating enzyme E1, C-terminal domain superfamily
    IPR032418 Ubiquitin-activating enzyme E1, FCCH domain
    IPR032420 Ubiquitin-activating enzyme E1, four-helix bundle
    IPR000011 Ubiquitin/SUMO-activating enzyme E1
Molecular
Reagents
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  • All nucleic 56
    Genomic 1
    cDNA 55

    Microarray probesets 5
Other
Accession IDs
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MGI:1921403
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:57881 Persons DA, et al., Fv2 encodes a truncated form of the Stk receptor tyrosine kinase [see comments]. Nat Genet. 1999 Oct;23(2):159-65
  • Latest
    J:227853 Fan JB, et al., Type I IFN induces protein ISGylation to enhance cytokine expression and augments colonic inflammation. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14313-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory