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Serinc3 Gene Detail
Summary
  • Symbol
    Serinc3
  • Name
    serine incorporator 3
  • Synonyms
    AIGP1, DIFF33, Tde1, TMS-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349457
    NCBI Gene: 26943
  • Gene Overview
    MyGene.info: SERINC3
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163465192-163487051 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349457
 protein coding gene Chr2:163465192-163487071 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026827
 protein coding gene Chr2:168980976-169002617 (-)
A/J MGP_AJ_G0026793
 protein coding gene Chr2:162165906-162187524 (-)
AKR/J MGP_AKRJ_G0026764
 protein coding gene Chr2:166958714-166984029 (-)
BALB/cJ MGP_BALBcJ_G0026802
 protein coding gene Chr2:162490650-162518198 (-)
C3H/HeJ MGP_C3HHeJ_G0026544
 protein coding gene Chr2:167314602-167337487 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027250
 protein coding gene Chr2:173909120-173932928 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024620
 protein coding gene Chr2:155468923-155490274 (-)
CAST/EiJ MGP_CASTEiJ_G0026005
 protein coding gene Chr2:167706340-167735447 (-)
CBA/J MGP_CBAJ_G0026521
 protein coding gene Chr2:180189351-180215351 (-)
DBA/2J MGP_DBA2J_G0026659
 protein coding gene Chr2:161334669-161356760 (-)
FVB/NJ MGP_FVBNJ_G0026625
 protein coding gene Chr2:159706970-159728901 (-)
LP/J MGP_LPJ_G0026762
 protein coding gene Chr2:169104129-169126773 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026647
 protein coding gene Chr2:183843114-183870179 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027306
 protein coding gene Chr2:166853806-166877578 (-)
PWK/PhJ MGP_PWKPhJ_G0025739
 protein coding gene Chr2:160897394-160921690 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025542
 protein coding gene Chr2:165725013-165752950 (-)
WSB/EiJ MGP_WSBEiJ_G0026075
 protein coding gene Chr2:167705337-167728400 (-)



Homology
more
  • Human Ortholog
    SERINC3, serine incorporator 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERINC3, serine incorporator 3
  • Synonyms
    AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1
  • Links
    NCBI Gene ID: 10955
    neXtProt AC: NX_Q13530
    UniProt: Q13530

  • Chr Location
    20q13.12; chr20:44496221-44522116 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    12
  • cDNA Data
    28
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017707 Ensembl Gene Model | MGI Sequence Detail 21860 C57BL/6J ±  kb
    transcript ENSMUST00000017851 Ensembl | MGI Sequence Detail 3683 Not Applicable  
    polypeptide ENSMUSP00000017851 Ensembl | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2138812, MGI:2138813
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
    • Latest
      J:291232 Timilsina U, et al., SERINC5 Potently Restricts Retrovirus Infection In Vivo. mBio. 2020 Jul 14;11(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/12/2021
    MGI 6.17     		The Jackson Laboratory