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Serinc3 Gene Detail
Summary
  • Symbol
    Serinc3
  • Name
    serine incorporator 3
  • Synonyms
    AIGP1, DIFF33, Tde1, TMS-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349457
    NCBI Gene: 26943
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:163466577-163487767 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1040 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349457
 protein coding gene Chr2:163465192-163487767 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026827
 protein coding gene Chr2:168980976-169002617 (-)
A/J MGP_AJ_G0026793
 protein coding gene Chr2:162165906-162187524 (-)
AKR/J MGP_AKRJ_G0026764
 protein coding gene Chr2:166958714-166984029 (-)
BALB/cJ MGP_BALBcJ_G0026802
 protein coding gene Chr2:162490650-162518198 (-)
C3H/HeJ MGP_C3HHeJ_G0026544
 protein coding gene Chr2:167314602-167337487 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027250
 protein coding gene Chr2:173909120-173932928 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024620
 protein coding gene Chr2:155468923-155490274 (-)
CAST/EiJ MGP_CASTEiJ_G0026005
 protein coding gene Chr2:167706340-167735447 (-)
CBA/J MGP_CBAJ_G0026521
 protein coding gene Chr2:180189351-180215351 (-)
DBA/2J MGP_DBA2J_G0026659
 protein coding gene Chr2:161334669-161356760 (-)
FVB/NJ MGP_FVBNJ_G0026625
 protein coding gene Chr2:159706970-159728901 (-)
LP/J MGP_LPJ_G0026762
 protein coding gene Chr2:169104129-169126773 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026647
 protein coding gene Chr2:183843114-183870179 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027306
 protein coding gene Chr2:166853806-166877578 (-)
PWK/PhJ MGP_PWKPhJ_G0025739
 protein coding gene Chr2:160897394-160921690 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025542
 protein coding gene Chr2:165725013-165752950 (-)
WSB/EiJ MGP_WSBEiJ_G0026075
 protein coding gene Chr2:167705337-167728400 (-)



Homology
more
  • Human Ortholog
    SERINC3, serine incorporator 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERINC3, serine incorporator 3
  • Synonyms
    AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1
  • Links
    NCBI Gene ID: 10955
    UniProt: Q13530

  • Chr Location
    20q13.12; chr20:44496221-44522085 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    12
  • cDNA Data
    28
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26943 NCBI Gene Model | MGI Sequence Detail 21191 C57BL/6J ±  kb
    transcript NM_001412448 RefSeq | MGI Sequence Detail 2533 C57BL/6  
    polypeptide Q9QZI9 UniProt | EBI | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2138812, MGI:2138813
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/18/2025
    MGI 6.24     		The Jackson Laboratory