Serinc3 MGI Mouse Gene Detail - MGI:1349457

Symbol

Serinc3
Name

serine incorporator 3
Synonyms

AIGP1, DIFF33, Tde1, TMS-1

Feature Type

protein coding gene
IDs

MGI:1349457
NCBI Gene: 26943
Gene Overview

MyGene.info: SERINC3
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr2:163623272-163645131 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 84.38 cM
Mapping Data

2 experiments

SNPs within 2kb

208 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349457	protein coding gene	Chr2:163623272-163645149 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026827	protein coding gene	Chr2:168980976-169002617 (-)
A/J	MGP_AJ_G0026793	protein coding gene	Chr2:162165906-162187524 (-)
AKR/J	MGP_AKRJ_G0026764	protein coding gene	Chr2:166958714-166984029 (-)
BALB/cJ	MGP_BALBcJ_G0026802	protein coding gene	Chr2:162490650-162518198 (-)
C3H/HeJ	MGP_C3HHeJ_G0026544	protein coding gene	Chr2:167314602-167337487 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0027250	protein coding gene	Chr2:173909120-173932928 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024620	protein coding gene	Chr2:155468923-155490274 (-)
CAST/EiJ	MGP_CASTEiJ_G0026005	protein coding gene	Chr2:167706340-167735447 (-)
CBA/J	MGP_CBAJ_G0026521	protein coding gene	Chr2:180189351-180215351 (-)
DBA/2J	MGP_DBA2J_G0026659	protein coding gene	Chr2:161334669-161356760 (-)
FVB/NJ	MGP_FVBNJ_G0026625	protein coding gene	Chr2:159706970-159728901 (-)
LP/J	MGP_LPJ_G0026762	protein coding gene	Chr2:169104129-169126773 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026647	protein coding gene	Chr2:183843114-183870179 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027306	protein coding gene	Chr2:166853806-166877578 (-)
PWK/PhJ	MGP_PWKPhJ_G0025739	protein coding gene	Chr2:160897394-160921690 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025542	protein coding gene	Chr2:165725013-165752950 (-)
WSB/EiJ	MGP_WSBEiJ_G0026075	protein coding gene	Chr2:167705337-167728400 (-)

Human Ortholog

SERINC3, serine incorporator 3

Vertebrate Orthologs

10

Human Ortholog

SERINC3, serine incorporator 3
Orthology source: HomoloGene, HGNC
Synonyms

AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1
Links

HGNC:11699

NCBI Gene ID: 10955

neXtProt AC: NX_Q13530

UniProt: Q13530
Chr Location

20q13.12; chr20:44496221-44522116 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 38230
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SERINC3
Gene Tree

Serinc3

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Gene trapped

15
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

12
cDNA Data

28
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase serinc3

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Serinc3 interacts with 286 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

65
RefSeq

6
UniProt

2
CCDS

CCDS17013.1

Ensembl

ENSMUSG00000017707 (Evidence)
NCBI Gene

26943

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017707	Ensembl Gene Model \| MGI Sequence Detail	21860	C57BL/6J	± kb
transcript	ENSMUST00000017851	Ensembl \| MGI Sequence Detail	3683	Not Applicable
polypeptide	ENSMUSP00000017851	Ensembl \| MGI Sequence Detail	472	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014673 serine incorporator 3

(term hierarchy)
InterPro Domains

IPR029557 Serine incorporator 1/3

IPR005016 Serine incorporator/TMS membrane protein

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All nucleic 28

cDNA 28

Microarray probesets 8

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MGI:2138812, MGI:2138813

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
Latest

J:291232 Timilsina U, et al., SERINC5 Potently Restricts Retrovirus Infection In Vivo. mBio. 2020 Jul 14;11(4)

TSS for Serinc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27326	Chr2:163645147-163645152 (-)	-19 bp
Tssr27325	Chr2:163645125-163645136 (-)	0 bp
Tssr27324	Chr2:163645107-163645112 (-)	21 bp
Tssr27323	Chr2:163645081-163645096 (-)	42 bp
Tssr27322	Chr2:163645051-163645056 (-)	77 bp
Tssr27321	Chr2:163644690-163644770 (-)	401 bp
Tssr27319	Chr2:163639197-163639342 (-)	5,861 bp
Tssr27318	Chr2:163636836-163636879 (-)	8,273 bp
Tssr27306	Chr2:163625470-163625534 (-)	19,629 bp
Tssr27305	Chr2:163625413-163625458 (-)	19,695 bp
Tssr27304	Chr2:163625112-163625126 (-)	20,012 bp
Tssr27303	Chr2:163624972-163625017 (-)	20,136 bp
Tssr27302	Chr2:163624864-163624971 (-)	20,213 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16