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Corin
Gene Detail
 Symbol
Name
ID
Corin
corin
MGI:1349451
Synonyms Lrp4
Feature Type protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:72300025-72504473 bp, - strand
From VEGA annotation of GRCm38

  204449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: atrial natriuteric peptide-converting enzyme
Gene Tree: Corin

Human
homologs
Human Homolog CORIN, corin, serine peptidase
NCBI Gene ID 10699
neXtProt AC  NX_Q9Y5Q5
Human Synonyms  ATC2, CRN, Lrp4, PEE5, TMPRSS10
Human Chr (Location)  4p13-p12; chr4:47593998-47838106 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CORIN
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy.
 
Interactions
Corin interacts with 279 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process female pregnancy, neuron differentiation, ...
Component cell surface, cytoplasmic membrane-bounded vesicle, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (45)    Tissues (17)    Images (26)
Theiler Stages: 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 26
RT-PCR 10
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000039797 (Evidence)
Ensembl Gene ModelENSMUSG00000005220 (Evidence)
Entrez Gene53419 (Evidence)
DFCITC1585838, TC1616333, TC1681800
DoTSDT.60104108, DT.91347691, DT.91435558, DT.94184895
NIA Mouse Gene IndexU026287
EC3.4.21.-
Consensus CDS ProjectCCDS19330.1, CCDS51513.1
International Mouse Knockout Project StatusCorin
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039797 VEGA Gene Model | MGI Sequence Detail 204449 C57BL/6J ±  kb
transcript OTTMUST00000103451 VEGA | MGI Sequence Detail 4862 Not Applicable 
polypeptide OTTMUSP00000057804 VEGA | MGI Sequence Detail 1113 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(1058 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR001254 Peptidase S1
InterPro IPR017052 Peptidase S1A, corin
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000005758 atrial natriuretic peptide-converting enzyme
References (Earliest) J:55430 Tomita Y, et al., A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart. J Biochem. 1998 Oct;124(4):784-9
(Latest) J:202344 Lesko MH, et al., Sox2 modulates the function of two distinct cell lineages in mouse skin. Dev Biol. 2013 Oct 1;382(1):15-26
All references(59)
Other
accession IDs
MGI:2141119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory