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Corin
Gene Detail
Symbol

Name
ID
Corin
corin
MGI:1349451
Synonyms
Lrp4
Feature Type
protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:72300025-72504473 bp, - strand
From VEGA annotation of GRCm38

  204449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4804  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CORIN
Protein SuperFamily: atrial natriuteric peptide-converting enzyme
Gene Tree: Corin

Human
homologs
CORIN, corin, serine peptidase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10699
neXtProt AC: NX_Q9Y5Q5

Human Synonyms: ATC2, CRN, Lrp4, PEE5, TMPRSS10

Human Chr (Location): 4p12; chr4:47593998-47838106 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CORIN

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Radiation induced(1) Targeted(6)
Genomic Mutations involving Corin (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy.
 
Phenotype Images(4)
Interactions
Corin interacts with 279 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process female pregnancy, neuron differentiation, ...
Component cell surface, cytoplasmic membrane-bounded vesicle, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (45)    Tissues (20)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 26
RT-PCR 10
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase corin    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000039797 (Evidence)
Ensembl Gene Model ENSMUSG00000005220 (Evidence)
Entrez Gene 53419 (Evidence)
DFCI TC1585838, TC1616333, TC1681800
DoTS DT.60104108, DT.91347691, DT.91435558, DT.94184895
NIA Mouse Gene Index U026287
EC 3.4.21.-
Consensus CDS Project CCDS19330.1, CCDS51513.1
International Mouse Phenotyping Consortium Status Corin
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039797 VEGA Gene Model | MGI Sequence Detail 204449 C57BL/6J ±  kb
transcript OTTMUST00000103451 VEGA | MGI Sequence Detail 4862 Not Applicable 
polypeptide OTTMUSP00000057804 VEGA | MGI Sequence Detail 1113 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(1058 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017052 Atrial natriuretic peptide-converting enzyme corin
InterPro IPR020067 Frizzled domain
InterPro IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
InterPro IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
InterPro IPR001190 SRCR domain
InterPro IPR017448 SRCR-like domain
Protein Ontology PR:000005758 atrial natriuretic peptide-converting enzyme
References
(Earliest) J:55430 Tomita Y, et al., A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart. J Biochem. 1998 Oct;124(4):784-9
(Latest) J:220736 Bye CR, et al., Transcriptome analysis reveals transmembrane targets on transplantable midbrain dopamine progenitors. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1946-55
All references(60)
Other
accession IDs
MGI:2141119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory