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Corin Gene Detail
Summary
  • Symbol
    Corin
  • Name
    corin
  • Synonyms
    Lrp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349451
    NCBI Gene: 53419
  • Gene Overview
    MyGene.info: CORIN
Location & Maps
more
  • Sequence Map
    Chr5:72300025-72504473 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      204449 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CORIN, corin, serine peptidase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CORIN, corin, serine peptidase
    Orthology source: HomoloGene
  • Synonyms
    ATC2, CRN, Lrp4, PEE5, TMPRSS10
  • Links
    NCBI Gene ID: 10699
    neXtProt AC: NX_Q9Y5Q5

  • Chr Location
    4p12; chr4:47593998-47838106 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CORIN associations

Human Disease Mouse Models
       Preeclampsia/Eclampsia 5; PEE5   OMIM: 614595
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    4 involving Corin
  • Incidental Mutations
Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039797 VEGA Gene Model | MGI Sequence Detail 204449 C57BL/6J ±  kb
transcript OTTMUST00000103451 VEGA | MGI Sequence Detail 4862 Not Applicable  
polypeptide OTTMUSP00000057804 VEGA | MGI Sequence Detail 1113 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1056 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005758 atrial natriuretic peptide-converting enzyme
  • EC
  • InterPro Domains
    IPR017052 Atrial natriuretic peptide-converting enzyme corin
    IPR020067 Frizzled domain
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR033116 Serine proteases, trypsin family, serine active site
    IPR001190 SRCR domain
    IPR017448 SRCR-like domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141119
References
more
  • Summaries
    All 60
    Developmental Gene Expression 21
    Gene Ontology 9
    Phenotypes 30
  • Earliest
    J:55430 Tomita Y, et al., A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart. J Biochem. 1998 Oct;124(4):784-9
  • Latest
    J:228881 Gazea M, et al., Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016 Jan 1;409(1):55-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory