Haao MGI Mouse Gene Detail - MGI:1349444 - 3-hydroxyanthranilate 3,4-dioxygenase

Symbol

Haao
Name

3-hydroxyanthranilate 3,4-dioxygenase
Synonyms

0610007K21Rik, 0610012J07Rik, 3HAO, 3-HAO, 3-HAOxase

Feature Type

protein coding gene
IDs

MGI:1349444
NCBI Gene: 107766
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr17:83831348-83847958 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 54.85 cM, cytoband E4
Mapping Data

2 experiments

SNPs within 2kb

251 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349444	protein coding gene	Chr17:83831156-83847963 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024076	protein coding gene	Chr17:86942261-86960418 (-)
A/J	MGP_AJ_G0024035	protein coding gene	Chr17:84208374-84225034 (-)
AKR/J	MGP_AKRJ_G0024004	protein coding gene	Chr17:85562439-85579810 (-)
BALB/cJ	MGP_BALBcJ_G0024036	protein coding gene	Chr17:84064947-84080089 (-)
C3H/HeJ	MGP_C3HHeJ_G0023801	protein coding gene	Chr17:86416683-86433174 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024481	protein coding gene	Chr17:90059031-90075594 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021920	protein coding gene	Chr17:79419810-79435439 (-)
CAST/EiJ	MGP_CASTEiJ_G0023280	protein coding gene	Chr17:87156668-87174797 (-)
CBA/J	MGP_CBAJ_G0023775	protein coding gene	Chr17:93766814-93785617 (-)
DBA/2J	MGP_DBA2J_G0023903	protein coding gene	Chr17:82696907-82712201 (-)
FVB/NJ	MGP_FVBNJ_G0023869	protein coding gene	Chr17:82174021-82189936 (-)
LP/J	MGP_LPJ_G0023987	protein coding gene	Chr17:87693456-87713031 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023897	protein coding gene	Chr17:93904606-93919969 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024526	protein coding gene	Chr17:86063118-86079427 (-)
PWK/PhJ	MGP_PWKPhJ_G0023025	protein coding gene	Chr17:82249002-82266408 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022836	protein coding gene	Chr17:82839497-82854862 (-)
WSB/EiJ	MGP_WSBEiJ_G0023347	protein coding gene	Chr17:86910142-86928438 (-)

Human Ortholog

HAAO, 3-hydroxyanthranilate 3,4-dioxygenase

Vertebrate Orthologs

9

Human Ortholog

HAAO, 3-hydroxyanthranilate 3,4-dioxygenase
Orthology source: HomoloGene, HGNC
Synonyms

3-HAO, h3HAO, HAO, VCRL1
Links

HGNC:4796

NCBI Gene ID: 23498

neXtProt AC: NX_P46952

UniProt: P46952
Chr Location

2p21; chr2:42766198-42794359 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8148
1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HAAO
Protein SuperFamily

3-hydroxyanthranilate 3,4-dioxygenase, animal type
Gene Tree

Haao

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced LPS-induced depressive behaviors and altered kynurenine metabolism.

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All GO Annotations

26
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

94
Tissues

94
cDNA Data

96
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase haao

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Haao interacts with 41 markers (Mir18b, Mir93, Mir135a-1, ...) View All

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All Sequences

49
RefSeq

11
UniProt

1
CCDS

CCDS37709.1
UniGene

30100

Ensembl

ENSMUSG00000000673 (Evidence)
NCBI Gene

107766

			Length	Strain/Species	Flank
genomic	107766	NCBI Gene Model \| MGI Sequence Detail	16611	C57BL/6J	± kb
transcript	NM_025325	RefSeq \| MGI Sequence Detail	1252	FVB/N
polypeptide	Q78JT3	UniProt \| EBI \| MGI Sequence Detail	286	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008427 3-hydroxyanthranilate 3,4-dioxygenase

(term hierarchy)
EC

1.13.11.6
InterPro Domains

IPR016700 3-hydroxyanthranilate 3, 4-dioxygenase, metazoan

IPR010329 3-hydroxyanthranilic acid dioxygenase

IPR011051 RmlC-like cupin domain superfamily

IPR014710 RmlC-like jelly roll fold

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All nucleic 98

Genomic 2

cDNA 96

Microarray probesets 3

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MGI:1913307, MGI:1918919

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 8

Phenotypes 6
Earliest

J:131587 Nakano K, et al., Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Brain Res. 1992 Feb 14;572(1-2):1-4
Latest

J:240498 Parrott JM, et al., Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. Transl Psychiatry. 2016 Oct 18;6(10):e918

TSS for Haao:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr149617	Chr17:83847887-83847923 (-)	53 bp
Tssr149616	Chr17:83846889-83846905 (-)	1,061 bp
Tssr149615	Chr17:83846870-83846879 (-)	1,083 bp
Tssr149614	Chr17:83846769-83846810 (-)	1,168 bp
Tssr149613	Chr17:83846762-83846765 (-)	1,194 bp
Tssr149612	Chr17:83846746-83846757 (-)	1,206 bp
Tssr149611	Chr17:83846729-83846742 (-)	1,222 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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