Haao MGI Mouse Gene Detail - MGI:1349444 - 3-hydroxyanthranilate 3,4-dioxygenase

Haao Gene Detail

Symbol

Haao
Name

3-hydroxyanthranilate 3,4-dioxygenase
Synonyms

0610007K21Rik, 0610012J07Rik, 3HAO, 3-HAO, 3-HAOxase

Feature Type

protein coding gene
IDs

MGI:1349444
NCBI Gene: 107766
Alliance

gene page

Sequence Map

Chr17:83831356-83846790 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

15435 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 54.85 cM, cytoband E4
Mapping Data

2 experiments

Human Ortholog

HAAO, 3-hydroxyanthranilate 3,4-dioxygenase

Vertebrate Orthologs

9

Human Ortholog

HAAO, 3-hydroxyanthranilate 3,4-dioxygenase
Orthology source: HomoloGene, HGNC
Synonyms

3-HAO, HAO, VCRL1
Links

HGNC:4796

NCBI Gene ID: 23498

neXtProt AC: NX_P46952

UniProt: P46952
Chr Location

2p21; chr2:42766198-42794359 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8148
1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HAAO
Protein SuperFamily

3-hydroxyanthranilate 3,4-dioxygenase, animal type
Gene Tree

Haao

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced LPS-induced depressive behaviors and altered kynurenine metabolism.

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All GO Annotations

23
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

94
Tissues

94
cDNA Data

96
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase haao

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Haao interacts with 41 markers (Mir18b, Mir93, Mir135a-1, ...) View All

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All Sequences

23
RefSeq

11
UniProt

1
CCDS

CCDS37709.1
UniGene

30100

Ensembl

ENSMUSG00000000673 (Evidence)
NCBI Gene

107766

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000673	Ensembl Gene Model \| MGI Sequence Detail	15435	C57BL/6J	± kb
transcript	ENSMUST00000000687	Ensembl \| MGI Sequence Detail	1222	Not Applicable
polypeptide	ENSMUSP00000000687	Ensembl \| MGI Sequence Detail	286	Not Applicable

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SNPs within 2kb

251 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000008427 3-hydroxyanthranilate 3,4-dioxygenase

(term hierarchy)
EC

1.13.11.6
InterPro Domains

IPR016700 3-hydroxyanthranilate 3, 4-dioxygenase, metazoan

IPR010329 3-hydroxyanthranilic acid dioxygenase

IPR011051 RmlC-like cupin domain superfamily

IPR014710 RmlC-like jelly roll fold

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All nucleic 97

Genomic 1

cDNA 96

Microarray probesets 3

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MGI:1913307, MGI:1918919

Summaries

All 35

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 5
Earliest

J:131587 Nakano K, et al., Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice. Brain Res. 1992 Feb 14;572(1-2):1-4
Latest

J:240498 Parrott JM, et al., Neurotoxic kynurenine metabolism is increased in the dorsal hippocampus and drives distinct depressive behaviors during inflammation. Transl Psychiatry. 2016 Oct 18;6(10):e918

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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