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Eif2s3x Gene Detail
Summary
  • Symbol
    Eif2s3x
  • Name
    eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
  • Synonyms
    Eif-2gx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349431
    NCBI Gene: 26905
  • Gene Overview
    MyGene.info: EIF2S3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:94188709-94212651 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 41.52 cM, cytoband C-D
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349431
protein coding gene ChrX:94188707-94212862 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035908
protein coding gene ChrX:90584524-90608732 (-)
A/J MGP_AJ_G0035894
protein coding gene ChrX:90685119-90711430 (-)
AKR/J MGP_AKRJ_G0035811
protein coding gene ChrX:93072772-93107157 (-)
BALB/cJ MGP_BALBcJ_G0035878
protein coding gene ChrX:89386883-89410945 (-)
C3H/HeJ MGP_C3HHeJ_G0035587
protein coding gene ChrX:90945146-90978416 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036407
protein coding gene ChrX:93348154-93375440 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033234
protein coding gene ChrX:88832928-88856925 (-)
CAST/EiJ MGP_CASTEiJ_G0034872
protein coding gene ChrX:75618534-75654265 (-)
CBA/J MGP_CBAJ_G0035561
protein coding gene ChrX:96040696-96067931 (-)
DBA/2J MGP_DBA2J_G0035717
protein coding gene ChrX:89914972-89939549 (-)
FVB/NJ MGP_FVBNJ_G0035656
protein coding gene ChrX:89302545-89334083 (-)
LP/J MGP_LPJ_G0035806
protein coding gene ChrX:91377126-91402370 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035690
protein coding gene ChrX:100328251-100366229 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036434
protein coding gene ChrX:90300854-90326403 (-)
PWK/PhJ MGP_PWKPhJ_G0034571
protein coding gene ChrX:73397064-73421812 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034401
protein coding gene ChrX:76470740-76496204 (-)
WSB/EiJ MGP_WSBEiJ_G0035013
protein coding gene ChrX:89096983-89122575 (-)



Homology
more
  • Human Ortholog
    EIF2S3, eukaryotic translation initiation factor 2 subunit gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2S3, eukaryotic translation initiation factor 2 subunit gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EIF2, EIF2G, eIF-2gA, EIF2gamma, MEHMO, MRXSBRK
  • Links
    NCBI Gene ID: 1968
    neXtProt AC: NX_P41091
    UniProt: P41091

  • Chr Location
    Xp22.11; chrX:24054948-24078810 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human EIF2S3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26905 NCBI Gene Model | MGI Sequence Detail 23943 C57BL/6J ±  kb
transcript NM_012010 RefSeq | MGI Sequence Detail 3587 C57BL/6  
polypeptide Q9Z0N1 UniProt | EBI | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000026090 eukaryotic translation initiation factor 2 subunit 3, X-linked
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR015256 Translation initiation factor 2, gamma subunit, C-terminal
    IPR009000 Translation protein, beta-barrel domain superfamily
Molecular
Reagents
less
  • All nucleic 341
    Genomic 1
    cDNA 337
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2147826, MGI:2147862, MGI:3035384
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:50115 Ehrmann IE, et al., Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct;7(11):1725-37
  • Latest
    J:206774 Wolstenholme JT, et al., Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013 Mar;12(2):166-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory