About   Help   FAQ
Eif2s3x Gene Detail
Summary
  • Symbol
    Eif2s3x
  • Name
    eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked
  • Synonyms
    Eif-2gx
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349431
    NCBI Gene: 26905
  • Gene Overview
    MyGene.info: EIF2S3
Location & Maps
more
  • Sequence Map
    ChrX:94188707-94212862 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24156 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 41.52 cM, cytoband C-D
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    EIF2S3, eukaryotic translation initiation factor 2 subunit gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF2S3, eukaryotic translation initiation factor 2 subunit gamma
    Orthology source: HomoloGene
  • Synonyms
    EIF2, EIF2G, eIF-2gA, EIF2gamma
  • Links
    NCBI Gene ID: 1968
    neXtProt AC: NX_P41091

  • Chr Location
    Xp22.2-p22.1; chrX:24054948-24078810 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    5
  • Targeted
    3
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018084 VEGA Gene Model | MGI Sequence Detail 24156 C57BL/6J ±  kb
transcript OTTMUST00000043652 VEGA | MGI Sequence Detail 3647 Not Applicable  
polypeptide OTTMUSP00000019612 VEGA | MGI Sequence Detail 472 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    54 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000026090 eukaryotic translation initiation factor 2 subunit 3, X-linked
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004161 Translation elongation factor EFTu/EF1A, domain 2
    IPR015256 Translation initiation factor 2, gamma subunit, C-terminal
    IPR009000 Translation protein, beta-barrel domain
Molecular
Reagents
less
  • All nucleic 340
    Genomic 1
    cDNA 336
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2147826, MGI:2147862, MGI:3035384
References
more
  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:50115 Ehrmann IE, et al., Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct;7(11):1725-37
  • Latest
    J:206774 Wolstenholme JT, et al., Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013 Mar;12(2):166-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/24/2016
MGI 6.04
The Jackson Laboratory