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Arl2bp Gene Detail
Summary
  • Symbol
    Arl2bp
  • Name
    ADP-ribosylation factor-like 2 binding protein
  • Synonyms
    1700010P10Rik, 1700027H16Rik, BART, Bart1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349429
    NCBI Gene: 107566
Location & Maps
more
  • Sequence Map
    Chr8:94666600-94674425 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7826 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.65 cM, cytoband C5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ARL2BP, ADP ribosylation factor like GTPase 2 binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARL2BP, ADP ribosylation factor like GTPase 2 binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BART, BART1, RP66
  • Links
    NCBI Gene ID: 23568
    neXtProt AC: NX_Q9Y2Y0

  • Chr Location
    16q13; chr16:57245126-57253635 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 11479
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ARL2BP
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ARL2BP associations

Human Disease Mouse Models
       Retinitis Pigmentosa with or without Situs Inversus   OMIM: 615434
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Gene trapped
    1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061690 VEGA Gene Model | MGI Sequence Detail 7826 C57BL/6J ±  kb
transcript OTTMUST00000150522 VEGA | MGI Sequence Detail 2063 Not Applicable  
polypeptide OTTMUSP00000078036 VEGA | MGI Sequence Detail 163 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    16 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004283 ADP-ribosylation factor-like protein 2-binding protein
  • InterPro Domains
    IPR023379 ADP-ribosylation factor-like 2-binding protein, domain
Molecular
Reagents
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  • All nucleic 133
    cDNA 133

    Microarray probesets 4
Other
Accession IDs
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MGI:1914333, MGI:1922740, MGI:1923421, MGI:2142575, MGI:2142633
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 2
  • Earliest
    J:57774 Sharer JD, et al., The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. J Biol Chem. 1999 Sep 24;274(39):27553-61
  • Latest
    J:206686 Davidson AE, et al., Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa. Am J Hum Genet. 2013 Aug 8;93(2):321-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory