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Arl2bp Gene Detail
Summary
  • Symbol
    Arl2bp
  • Name
    ADP-ribosylation factor-like 2 binding protein
  • Synonyms
    1700010P10Rik, 1700027H16Rik, BART, Bart1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349429
    NCBI Gene: 107566
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94666600-94674425 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 46.65 cM, cytoband C5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349429
protein coding gene Chr8:94666600-94674457 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033965
protein coding gene Chr8:96097185-96106634 (+)
A/J MGP_AJ_G0033948
protein coding gene Chr8:92348987-92357406 (+)
AKR/J MGP_AKRJ_G0033874
protein coding gene Chr8:94868646-94877994 (+)
BALB/cJ MGP_BALBcJ_G0033940
protein coding gene Chr8:92439712-92447245 (+)
C3H/HeJ MGP_C3HHeJ_G0033650
protein coding gene Chr8:95585992-95595079 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034461
protein coding gene Chr8:99598787-99607375 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031402
protein coding gene Chr8:86156293-86164485 (+)
CAST/EiJ MGP_CASTEiJ_G0032982
protein coding gene Chr8:95170815-95178462 (+)
CBA/J MGP_CBAJ_G0033626
protein coding gene Chr8:102896559-102904212 (+)
DBA/2J MGP_DBA2J_G0033780
protein coding gene Chr8:91817057-91825061 (+)
FVB/NJ MGP_FVBNJ_G0033727
protein coding gene Chr8:90784441-90792065 (+)
LP/J MGP_LPJ_G0033872
protein coding gene Chr8:96247061-96256852 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033769
protein coding gene Chr8:105188457-105196114 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034479
protein coding gene Chr8:95038771-95047243 (+)
PWK/PhJ MGP_PWKPhJ_G0032684
protein coding gene Chr8:91197298-91205020 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032521
protein coding gene Chr8:93871942-93880343 (+)
WSB/EiJ MGP_WSBEiJ_G0033094
protein coding gene Chr8:95570255-95579854 (+)



Homology
more
  • Human Ortholog
    ARL2BP, ADP ribosylation factor like GTPase 2 binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARL2BP, ADP ribosylation factor like GTPase 2 binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BART, BART1, RP66
  • Links
    NCBI Gene ID: 23568
    neXtProt AC: NX_Q9Y2Y0
    UniProt: Q9Y2Y0

  • Chr Location
    16q13; chr16:57245126-57253635 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 11479
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ARL2BP
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Arl2bp mouse models; 1 with human ARL2BP associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit photoreceptor degeneration, progressive reduction in visual responses, outer segment disorganization with shortened axonemes and impaired ciliary doublet microtubule structure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031776 Ensembl Gene Model | MGI Sequence Detail 7826 C57BL/6J ±  kb
    transcript ENSMUST00000034228 Ensembl | MGI Sequence Detail 2063 Not Applicable  
    polypeptide ENSMUSP00000034228 Ensembl | MGI Sequence Detail 163 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      cDNA 134

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914333, MGI:1922740, MGI:1923421, MGI:2142575, MGI:2142633
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:57774 Sharer JD, et al., The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. J Biol Chem. 1999 Sep 24;274(39):27553-61
    • Latest
      J:279003 Moye AR, et al., Mutations in ARL2BP, a protein required for ciliary microtubule structure, cause syndromic male infertility in humans and mice. PLoS Genet. 2019 Aug;15(8):e1008315

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/26/2020
    MGI 6.15
    The Jackson Laboratory