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Exo1 Gene Detail
Summary
  • Symbol
    Exo1
  • Name
    exonuclease 1
  • Synonyms
    5730442G03Rik, Msa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349427
    NCBI Gene: 26909
  • Gene Overview
    MyGene.info: EXO1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:175880760-175911396 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 81.90 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349427
protein coding gene Chr1:175880581-175913489 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016841
protein coding gene Chr1:181979415-182011009 (+)
A/J MGP_AJ_G0016820
protein coding gene Chr1:174651294-174683272 (+)
AKR/J MGP_AKRJ_G0016786
protein coding gene Chr1:179883878-179917160 (+)
BALB/cJ MGP_BALBcJ_G0016778
protein coding gene Chr1:175183611-175216606 (+)
C3H/HeJ MGP_C3HHeJ_G0016603
protein coding gene Chr1:180477767-180509202 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017243
protein coding gene Chr1:187986173-188021371 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014948
protein coding gene Chr1:165960999-165991630 (+)
CAST/EiJ MGP_CASTEiJ_G0016184
protein coding gene Chr1:179849458-179881420 (+)
CBA/J MGP_CBAJ_G0016577
protein coding gene Chr1:194824235-194858478 (+)
DBA/2J MGP_DBA2J_G0016682
protein coding gene Chr1:173504250-173537950 (+)
FVB/NJ MGP_FVBNJ_G0016679
protein coding gene Chr1:171626689-171657902 (+)
LP/J MGP_LPJ_G0016758
protein coding gene Chr1:183171117-183203872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016711
protein coding gene Chr1:202083782-202118348 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017278
protein coding gene Chr1:179636276-179668643 (+)
PWK/PhJ MGP_PWKPhJ_G0015971
protein coding gene Chr1:172594723-172628107 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015748
protein coding gene Chr1:178672138-178706097 (+)
WSB/EiJ MGP_WSBEiJ_G0016246
protein coding gene Chr1:179842010-179873115 (+)



Homology
more
  • Human Ortholog
    EXO1, exonuclease 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXO1, exonuclease 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEX1, hExoI
  • Links
    NCBI Gene ID: 9156
    neXtProt AC: NX_Q9UQ84
    UniProt: Q9UQ84

  • Chr Location
    1q43; chr1:241847967-241889939 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31352
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EXO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced life span, lymphoma development, and male/female sterilty due to defective meiosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26909 NCBI Gene Model | MGI Sequence Detail 30637 C57BL/6J ±  kb
    transcript NM_012012 RefSeq | MGI Sequence Detail 5506 Not Specified  
    polypeptide Q9QZ11 UniProt | EBI | MGI Sequence Detail 837 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 66
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917804
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 23
    • Earliest
      J:58084 Lee BI, et al., Expression specificity of the mouse exonuclease 1 (mExo1) gene. Nucleic Acids Res. 1999 Oct 15;27(20):4114-20
    • Latest
      J:238694 Gong Y, et al., PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017 Jan 01;31(1):46-58

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory