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Exo1 Gene Detail
Summary
  • Symbol
    Exo1
  • Name
    exonuclease 1
  • Synonyms
    5730442G03Rik, Msa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349427
    NCBI Gene: 26909
  • Gene Overview
    MyGene.info: EXO1
Location & Maps
more
  • Sequence Map
    Chr1:175880581-175913489 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      32909 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 81.90 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    EXO1, exonuclease 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EXO1, exonuclease 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEX1, hExoI
  • Links
    NCBI Gene ID: 9156
    neXtProt AC: NX_Q9UQ84

  • Chr Location
    1q43; chr1:241847967-241909165 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31352
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: EXO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    2
  • Gene trapped
    19
  • Targeted
    4
  • Genomic Mutations
    2 involving Exo1
  • Incidental Mutations
Homozygous mutation of this gene results in reduced life span, lymphoma development, and male/female sterilty due to defective meiosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050253 VEGA Gene Model | MGI Sequence Detail 32909 C57BL/6J ±  kb
transcript OTTMUST00000127652 VEGA | MGI Sequence Detail 7796 Not Applicable  
polypeptide OTTMUSP00000068832 VEGA | MGI Sequence Detail 837 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    259 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 66
    cDNA 65
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1917804
References
more
  • Summaries
    All 53
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:58084 Lee BI, et al., Expression specificity of the mouse exonuclease 1 (mExo1) gene. Nucleic Acids Res. 1999 Oct 15;27(20):4114-20
  • Latest
    J:233050 Rein K, et al., EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele. Nucleic Acids Res. 2015 Sep 3;43(15):7371-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory