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Racgap1 Gene Detail
Summary
  • Symbol
    Racgap1
  • Name
    Rac GTPase-activating protein 1
  • Synonyms
    Band25, gtl11, GTPase, MgcRacGAP, mKIAA1478
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349423
    NCBI Gene: 26934
  • Gene Overview
    MyGene.info: RACGAP1
Location & Maps
more
  • Sequence Map
    Chr15:99620496-99651656 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31161 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
    Orthology source: HomoloGene
  • Synonyms
    CYK4, HsCYK-4, ID-GAP, MgcRacGAP
  • Links
    NCBI Gene ID: 29127
    neXtProt AC: NX_Q9H0H5

  • Chr Location
    12q13.12; chr12:49989162-50033136 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    24
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Racgap1
  • Incidental Mutations
Embryos homozygous for a gene-trapped allele exhibit pre-implantation lethality associated with the formation of multinucleated blastomeres and failure to complete cytokinesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035793 VEGA Gene Model | MGI Sequence Detail 31161 C57BL/6J ±  kb
transcript OTTMUST00000091617 VEGA | MGI Sequence Detail 3052 Not Applicable  
polypeptide OTTMUSP00000050478 VEGA | MGI Sequence Detail 628 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    169 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000013663 rac GTPase-activating protein 1
  • InterPro Domains
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
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  • All nucleic 158
    cDNA 158

    Microarray probesets 4
Other
Accession IDs
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MGI:2145962, MGI:2145986
References
more
  • Summaries
    All 42
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:46563 Toure A, et al., MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. J Biol Chem. 1998 Mar 13;273(11):6019-23
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory