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Racgap1 Gene Detail
Summary
  • Symbol
    Racgap1
  • Name
    Rac GTPase-activating protein 1
  • Synonyms
    Band25, gtl11, GTPase, MgcRacGAP, mKIAA1478
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349423
    NCBI Gene: 26934
  • Gene Overview
    MyGene.info: RACGAP1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99620496-99651656 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.13 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349423
protein coding gene Chr15:99620496-99651656 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022337
protein coding gene Chr15:101480843-101517711 (-)
A/J MGP_AJ_G0022295
protein coding gene Chr15:97433945-97465935 (-)
AKR/J MGP_AKRJ_G0022271
protein coding gene Chr15:100433332-100466589 (-)
BALB/cJ MGP_BALBcJ_G0022301
protein coding gene Chr15:97618772-97650337 (-)
C3H/HeJ MGP_C3HHeJ_G0022069
protein coding gene Chr15:100499374-100530868 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022746
protein coding gene Chr15:105264962-105301664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020272
protein coding gene Chr15:93329070-93359589 (-)
CAST/EiJ MGP_CASTEiJ_G0021593
protein coding gene Chr15:101366142-101402803 (-)
CBA/J MGP_CBAJ_G0022038
protein coding gene Chr15:108835985-108891636 (-)
DBA/2J MGP_DBA2J_G0022165
protein coding gene Chr15:96870625-96902146 (-)
FVB/NJ MGP_FVBNJ_G0022145
protein coding gene Chr15:95860457-95891490 (-)
LP/J MGP_LPJ_G0022236
protein coding gene Chr15:101627972-101662587 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022165
protein coding gene Chr15:112743812-112779556 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022761
protein coding gene Chr15:100543705-100576525 (-)
PWK/PhJ MGP_PWKPhJ_G0021332
protein coding gene Chr15:97012377-97044843 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021167
protein coding gene Chr15:100391720-100425923 (-)
WSB/EiJ MGP_WSBEiJ_G0021644
protein coding gene Chr15:101063472-101096628 (-)



Homology
more
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    RACGAP1, Rac GTPase activating protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CYK4, HsCYK-4, ID-GAP, MgcRacGAP
  • Links
    NCBI Gene ID: 29127
    neXtProt AC: NX_Q9H0H5
    UniProt: Q9H0H5

  • Chr Location
    12q13.12; chr12:49989162-50033136 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene-trapped allele exhibit pre-implantation lethality associated with the formation of multinucleated blastomeres and failure to complete cytokinesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26934 NCBI Gene Model | MGI Sequence Detail 31161 C57BL/6J ±  kb
    transcript NM_012025 RefSeq | MGI Sequence Detail 3071 C57BL/6  
    polypeptide Q9WVM1 UniProt | EBI | MGI Sequence Detail 628 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013663 rac GTPase-activating protein 1
    • InterPro Domains
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000198 Rho GTPase-activating protein domain
      IPR008936 Rho GTPase activation protein
    Molecular
    Reagents
    less
    • All nucleic 161
      cDNA 159
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145962, MGI:2145986
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 4
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory