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Racgap1
Gene Detail
 Symbol
Name
ID
Racgap1
Rac GTPase-activating protein 1
MGI:1349423
Synonyms Band25, gtl11, GTPase, MgcRacGAP, mKIAA1478
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:99620496-99651656 bp, - strand
From VEGA annotation of GRCm38

  31161 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8077  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Racgap1

Human
homologs
Human Homolog RACGAP1, Rac GTPase activating protein 1
NCBI Gene ID 29127
neXtProt AC  NX_Q9H0H5
Human Synonyms  CYK4, HsCYK-4, ID-GAP, MgcRacGAP
Human Chr (Location)  12q13.12; chr12:49989162-50031749 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(24) Radiation induced(1) Targeted(2)
Genomic Mutations involving Racgap1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a gene-trapped allele exhibit pre-implantation lethality associated with the formation of multinucleated blastomeres and failure to complete cytokinesis.
 
Interactions
Racgap1 interacts with 131 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process actomyosin contractile ring assembly, cell cycle, ...
Component centralspindlin complex, cleavage furrow, ...
Function alpha-tubulin binding, beta-tubulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (70)    Tissues (22)    Images (20)
Theiler Stages: 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 70
cDNA source data(157)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(158) cDNA(158)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035793 (Evidence)
Ensembl Gene ModelENSMUSG00000023015 (Evidence)
Entrez Gene26934 (Evidence)
UniGene273804
DFCITC1573455
DoTSDT.101404556, DT.101738401, DT.110757801, DT.110785548, DT.492848, DT.97386701
Consensus CDS ProjectCCDS27825.1
International Mouse Knockout Project StatusRacgap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035793 VEGA Gene Model | MGI Sequence Detail 31161 C57BL/6J ±  kb
transcript OTTMUST00000091617 VEGA | MGI Sequence Detail 3052 Not Applicable 
polypeptide OTTMUSP00000050478 VEGA | MGI Sequence Detail 628 Not Applicable 

For the selected sequences
All sequences(162) RefSeq(10) UniProt(6)
Polymorphisms SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000013663 rac GTPase-activating protein 1
References (Earliest) J:46563 Toure A, et al., MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. J Biol Chem. 1998 Mar 13;273(11):6019-23
(Latest) J:206583 Lores P, et al., Deletion of MgcRacGAP in the male germ cells impairs spermatogenesis and causes male sterility in the mouse. Dev Biol. 2014 Feb 15;386(2):419-27
All references(43)
Other
accession IDs
MGI:2145962, MGI:2145986

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory