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Cops5
Gene Detail
Symbol

Name
ID
Cops5
COP9 (constitutive photomorphogenic) homolog, subunit 5 (Arabidopsis thaliana)
MGI:1349415
Synonyms
COP9 complex S5, CSN5, Jab1, JUN activation binding protein, Sgn5
Feature Type
protein coding gene
Genetic Map
Chromosome 1
2.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:10024601-10038168 bp, - strand
From VEGA annotation of GRCm38

  13568 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COPS5
Protein SuperFamily: hypothetical protein, Caenorhabditis elegans B0547.1 type
Gene Tree: Cops5

Human
homologs
COPS5, COP9 signalosome subunit 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10987
neXtProt AC: NX_Q92905

Human Synonyms: CSN5, JAB1, MOV-34, SGN5

Human Chr (Location): 8q13.1; chr8:67043079-67062327 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(14) Targeted(6)
Incidental mutations (data from APF , CvDC )
 
Homozygous null mice die soon after implantation and exhibit growth-retardation, decrease in cell proliferation, and an increase in cell apoptosis.
 
Interactions
Cops5 interacts with 99 markers (Mir16-1, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cullin deneddylation, exosomal secretion, ...
Component cell junction, COP9 signalosome, ...
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (222)    Tissues (120)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 197
Northern blot 12
Western blot 11
RT-PCR 2
cDNA source data(161)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cops5    NEW 
Molecular
reagents
All nucleic(163) cDNA(162) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029459 (Evidence)
Ensembl Gene Model ENSMUSG00000025917 (Evidence)
Entrez Gene 26754 (Evidence)
UniGene 402384
DFCI TC1629030, TC1667739, TC1572379
DoTS DT.101272233, DT.101386983, DT.494513, DT.110924521
NIA Mouse Gene Index U021118
EC 3.4.-.-
Consensus CDS Project CCDS14818.1
International Mouse Phenotyping Consortium Status Cops5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029459 VEGA Gene Model | MGI Sequence Detail 13568 C57BL/6J ±  kb
transcript OTTMUST00000072996 VEGA | MGI Sequence Detail 1698 Not Applicable 
polypeptide OTTMUSP00000037726 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(5) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000555 JAB1/Mov34/MPN/PAD-1
Protein Ontology PR:000005742 COP9 signalosome complex subunit 5
References
(Earliest) J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
(Latest) J:208363 Porrello E, et al., Jab1 regulates Schwann cell proliferation and axonal sorting through p27. J Exp Med. 2014 Jan 13;211(1):29-43
All references(54)
Other
accession IDs
MGI:2138191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory