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Cops5 Gene Detail
Summary
  • Symbol
    Cops5
  • Name
    COP9 signalosome subunit 5
  • Synonyms
    COP9 complex S5, CSN5, Jab1, JUN activation binding protein, Sgn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349415
    NCBI Gene: 26754
Location & Maps
more
  • Sequence Map
    Chr1:10024601-10038168 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13568 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    COPS5, COP9 signalosome subunit 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COPS5, COP9 signalosome subunit 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSN5, JAB1, MOV-34, SGN5
  • Links
    NCBI Gene ID: 10987
    neXtProt AC: NX_Q92905

  • Chr Location
    8q13.1; chr8:67043079-67062327 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    14
  • Targeted
    6
  • Incidental Mutations
    APF , CvDC
Homozygous null mice die soon after implantation and exhibit growth-retardation, decrease in cell proliferation, and an increase in cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029459 VEGA Gene Model | MGI Sequence Detail 13568 C57BL/6J ±  kb
transcript OTTMUST00000072996 VEGA | MGI Sequence Detail 1698 Not Applicable  
polypeptide OTTMUSP00000037726 VEGA | MGI Sequence Detail 334 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    108 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005742 COP9 signalosome complex subunit 5
  • EC
  • InterPro Domains
    IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
Molecular
Reagents
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  • All nucleic 163
    cDNA 162
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGI:2138191
References
more
  • Summaries
    All 51
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
  • Latest
    J:208363 Porrello E, et al., Jab1 regulates Schwann cell proliferation and axonal sorting through p27. J Exp Med. 2014 Jan 13;211(1):29-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory