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Cops4
Gene Detail
Symbol

Name
ID
Cops4
COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana)
MGI:1349414
Synonyms
COP9 complex S4, D5Ertd774e
Feature Type
protein coding gene
Genetic Map
Chromosome 5
48.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:100518309-100547803 bp, + strand
From VEGA annotation of GRCm38

  29495 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: COPS4
Gene Tree: Cops4

Human
homologs
COPS4, COP9 signalosome subunit 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 51138
neXtProt AC: NX_Q9BT78

Human Synonyms: CSN4

Human Chr (Location): 4q21.22; chr4:83035086-83075818 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(14) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cops4 interacts with 125 markers (Mir18, Mir18b, Mir20a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cullin deneddylation, protein deneddylation
Component cell junction, COP9 signalosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (22)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(193)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cops4    NEW 
Molecular
reagents
All nucleic(194) cDNA(193) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026140 (Evidence)
Ensembl Gene Model ENSMUSG00000035297 (Evidence)
Entrez Gene 26891 (Evidence)
UniGene 957
DFCI TC1582350, TC1600252, TC1601499, TC1623033, TC1657003
DoTS DT.101226970, DT.101379801, DT.110654081, DT.495127, DT.91381025
NIA Mouse Gene Index U005861
PDB 1UFM
Consensus CDS Project CCDS19463.1
International Mouse Phenotyping Consortium Status Cops4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026140 VEGA Gene Model | MGI Sequence Detail 29495 C57BL/6J ±  kb
transcript OTTMUST00000064556 VEGA | MGI Sequence Detail 1755 Not Applicable 
polypeptide OTTMUSP00000032088 VEGA | MGI Sequence Detail 406 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(8) UniProt(7)
Polymorphisms
SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000717 Proteasome component (PCI) domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000005741 COP9 signalosome complex subunit 4
References
(Earliest) J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(40)
Other
accession IDs
MGI:1289319, MGI:2141171

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory