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Clec4a2 Gene Detail
Summary
  • Symbol
    Clec4a2
  • Name
    C-type lectin domain family 4, member a2
  • Synonyms
    Clecsf6, DCIR, Dcir1, dendritic cell immunoreceptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349412
    NCBI Gene: 26888
  • Gene Overview
    MyGene.info: CLEC4A
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:123122690-123143999 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 58.18 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    266 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349412
protein coding gene Chr6:123106428-123143999 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031240
protein coding gene Chr6:126248285-126293614 (+)
A/J MGP_AJ_G0031209
protein coding gene Chr6:121433922-121466762 (+)
AKR/J MGP_AKRJ_G0031139
protein coding gene Chr6:124800311-124840014 (+)
BALB/cJ MGP_BALBcJ_G0031219
protein coding gene Chr6:121160473-121190229 (+)
C3H/HeJ MGP_C3HHeJ_G0030938
protein coding gene Chr6:124757535-124791528 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031678
protein coding gene Chr6:129573887-129609412 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028833
protein coding gene Chr6:118027577-118045381 (+)
CAST/EiJ MGP_CASTEiJ_G0030327
protein coding gene Chr6:125026259-125063512 (+)
CBA/J MGP_CBAJ_G0030901
protein coding gene Chr6:134631708-134688586 (+)
DBA/2J MGP_DBA2J_G0031057
protein coding gene Chr6:120380123-120417440 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031138
protein coding gene Chr6:126428535-126459776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031045
protein coding gene Chr6:138577229-138618609 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031707
protein coding gene Chr6:124693204-124729314 (+)
PWK/PhJ MGP_PWKPhJ_G0030041
protein coding gene Chr6:119211693-119237364 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029868
protein coding gene Chr6:122817408-122855180 (+)
WSB/EiJ MGP_WSBEiJ_G0030409
protein coding gene Chr6:124994888-125032477 (+)



Homology
more
  • Human Ortholog
    CLEC4A, C-type lectin domain family 4 member A
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CLEC4A, C-type lectin domain family 4 member A
    Orthology source: HomoloGene
  • Synonyms
    CD367, CLECSF6, DCIR, DDB27, HDCGC13P, LLIR
  • Links
    NCBI Gene ID: 50856
    neXtProt AC: NX_Q9UMR7
    UniProt: Q9UMR7

  • Chr Location
    12p13.31; chr12:8102932-8138607 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased IgG2a, IgG2b and IgG3 levels, increased B cell proliferation, enlarged lymph nodes and degeneration of seminiferous tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 26888 NCBI Gene Model | MGI Sequence Detail 21310 C57BL/6J ±  kb
transcript NM_001170333 RefSeq | MGI Sequence Detail 2553 C57BL/6  
polypeptide Q9QZ15 UniProt | EBI | MGI Sequence Detail 238 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR033989 CD209-like, C-type lectin-like domain
    IPR018378 C-type lectin, conserved site
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 5
References
more
  • Summaries
    All 30
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:56741 Bates EE, et al., APCs express DCIR, a novel C-type lectin surface receptor containing an immunoreceptor tyrosine-based inhibitory motif. J Immunol. 1999 Aug 15;163(4):1973-83
  • Latest
    J:264938 Troegeler A, et al., C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells. Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):E540-E549

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory