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Triobp
Gene Detail
Symbol

Name
ID
Triobp
TRIO and F-actin binding protein
MGI:1349410
Synonyms
EST478828, Mus EST 478828, Tara
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:78947724-79005867 bp, + strand
From VEGA annotation of GRCm38

  58144 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Triobp

Human
homologs
Human Homolog TRIOBP, TRIO and F-actin binding protein
NCBI Gene ID 11078
neXtProt AC  NX_Q9H2D6
Human Synonyms  DFNB28, dJ37E16.4, TAP68, TARA
Human Chr (Location)  22q13.1; chr22:37696988-37776556 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRIOBP
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Radiation induced(1) Targeted(1)
Genomic Mutations involving Triobp (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration.
 
Interactions
Triobp interacts with 194 markers (Mir10a, Mir10b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, cell division, ...
Component actin cytoskeleton, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(98)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(98) cDNA(98)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023632 (Evidence)
Ensembl Gene ModelENSMUSG00000033088 (Evidence)
Entrez Gene110253 (Evidence)
UniGene123714
DFCITC1574503, TC1584857, TC1596697, TC1619241, TC1644306, TC1686708, TC1703666
DoTSDT.101134945, DT.101342603, DT.101352046, DT.110823529, DT.55100047, DT.91395251, DT.94264709, DT.99850178
NIA Mouse Gene IndexU016416
Consensus CDS ProjectCCDS37136.1, CCDS37137.1, CCDS37138.1
International Mouse Knockout Project StatusTriobp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023632 VEGA Gene Model | MGI Sequence Detail 58144 C57BL/6J ±  kb
transcript OTTMUST00000057683 VEGA | MGI Sequence Detail 7023 Not Applicable 
polypeptide OTTMUSP00000027844 VEGA | MGI Sequence Detail 2014 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(24) UniProt(5)
Polymorphisms
SNPs within 2kb(395 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000016669 TRIO and F-actin-binding protein
References
(Earliest) J:56036 Southard-Smith EM, et al., Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human. Mamm Genome. 1999 Jul;10(7):744-9
(Latest) J:200106 Duncan JS, et al., Continued expression of GATA3 is necessary for cochlear neurosensory development. PLoS One. 2013;8(4):e62046
All references(39)
Other
accession IDs
MGI:1349446, MGI:2146002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory