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Triobp
Gene Detail
Symbol

Name
ID
Triobp
TRIO and F-actin binding protein
MGI:1349410
Synonyms
EST478828, Mus EST 478828, Tara
Feature Type
protein coding gene
Genetic Map
Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:78947724-79005867 bp, + strand
From VEGA annotation of GRCm38

  58144 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TRIOBP
Gene Tree: Triobp

Human
homologs
TRIOBP, TRIO and F-actin binding protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11078
neXtProt AC: NX_Q9H2D6

Human Synonyms: DFNB28, dJ37E16.4, HRIHFB2122, TAP68, TARA

Human Chr (Location): 22q13.1; chr22:37696988-37776556 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TRIOBP

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Radiation induced(1) Targeted(1)
Genomic Mutations involving Triobp (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration.
 
Phenotype Images(2)
Interactions
Triobp interacts with 193 markers (Mir10a, Mir10b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell cycle, cell division, ...
Component actin cytoskeleton, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(98)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase triobp    NEW 
Molecular
reagents
All nucleic(98) cDNA(98)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023632 (Evidence)
Ensembl Gene Model ENSMUSG00000033088 (Evidence)
Entrez Gene 110253 (Evidence)
UniGene 123714
DFCI TC1644306, TC1574503, TC1619241, TC1703666, TC1686708, TC1596697, TC1584857
DoTS DT.101134945, DT.101342603, DT.99850178, DT.55100047, DT.91395251, DT.94264709, DT.101352046, DT.110823529
NIA Mouse Gene Index U016416
Consensus CDS Project CCDS37136.1, CCDS37137.1, CCDS37138.1
International Mouse Phenotyping Consortium Status Triobp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023632 VEGA Gene Model | MGI Sequence Detail 58144 C57BL/6J ±  kb
transcript OTTMUST00000057683 VEGA | MGI Sequence Detail 7023 Not Applicable 
polypeptide OTTMUSP00000027844 VEGA | MGI Sequence Detail 2014 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(24) UniProt(5)
Polymorphisms
SNPs within 2kb(395 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000016669 TRIO and F-actin-binding protein
References
(Earliest) J:56036 Southard-Smith EM, et al., Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human. Mamm Genome. 1999 Jul;10(7):744-9
(Latest) J:200106 Duncan JS, et al., Continued expression of GATA3 is necessary for cochlear neurosensory development. PLoS One. 2013;8(4):e62046
All references(38)
Other
accession IDs
MGI:1349446, MGI:2146002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory