Triobp
Gene Detail

Symbol Name ID

Triobp TRIO and F-actin binding protein MGI:1349410

Synonyms

EST478828, Mus EST 478828, Tara

Feature Type

protein coding gene

Genetic Map

Chromosome 15

37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:78947724-79005867 bp, + strand From VEGA annotation of GRCm38   58144 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5104  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Triobp

Human homologs

Human Homolog		TRIOBP, TRIO and F-actin binding protein
NCBI Gene ID		11078
neXtProt AC		NX_Q9H2D6
Human Synonyms		DFNB28, dJ37E16.4, TARA
Human Chr (Location)		22q13.1; chr22:38092995-38172563 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRIOBP

Alleles and phenotypes

All alleles(10) : Targeted(1) Gene trapped(9)
 

Mice homozygous for gene trapped alleles exhibit embryonic lethality. Mice homozygous for a targeted allele eliminating isoforms 4 and 5 exhibit profound deafness associated with stereocilia fragility and degeneration.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	positive regulation of substrate adhesion-dependent cell spreading
Component	actin cytoskeleton, cytoplasm, ...
Function	actin binding, actin filament binding, ...

External Resources: FuncBase

Expression

cDNA source data(98)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) cDNA(98)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023632 (Evidence)
Ensembl Gene Model	ENSMUSG00000033088 (Evidence)
Entrez Gene	110253 (Evidence)
UniGene	123714
DFCI	TC1574503, TC1584857, TC1596697, TC1619241, TC1644306, TC1686708, TC1703666
DoTS	DT.101134945, DT.101342603, DT.101352046, DT.110823529, DT.55100047, DT.91395251, DT.94264709, DT.99850178
NIA Mouse Gene Index	U016416
Consensus CDS Project	CCDS37136.1, CCDS37137.1, CCDS37138.1
International Mouse Knockout Project Status	Triobp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023632	VEGA Gene Model | MGI Sequence Detail	58144	C57BL/6J
transcript	OTTMUST00000057683	VEGA | MGI Sequence Detail	7023	Not Applicable
polypeptide	OTTMUSP00000027844	VEGA | MGI Sequence Detail	2014	Not Applicable

All sequences(97) RefSeq(8) UniProt(7)

Polymorphisms

SNPs(298 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000016669	TRIO and F-actin-binding protein

References

(Earliest) J:56036 Southard-Smith EM, et al., Comparative analyses of the Dominant megacolon-SOX10 genomic interval in mouse and human. Mamm Genome. 1999 Jul;10(7):744-9
(Latest) J:171349 Yano T, et al., Tara up-regulates E-cadherin transcription by binding to the Trio RhoGEF and inhibiting Rac signaling. J Cell Biol. 2011 Apr 18;193(2):319-32
All references(39)

Other accession IDs

MGI:1349446, MGI:2146002