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Cops3 Gene Detail
Summary
  • Symbol
    Cops3
  • Name
    COP9 signalosome subunit 3
  • Synonyms
    COP9 complex S3, Csn3, Sgn3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349409
    NCBI Gene: 26572
Location & Maps
more
  • Sequence Map
    Chr11:59817795-59839838 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22044 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.80 cM, cytoband B2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    COPS3, COP9 signalosome subunit 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    COPS3, COP9 signalosome subunit 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CSN3, SGN3
  • Links
    NCBI Gene ID: 8533
    neXtProt AC: NX_Q9UNS2

  • Chr Location
    17p11.2; chr17:17246624-17281303 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2710
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: COPS3
  • Gene Tree
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    7
  • Genomic Mutations
    4 involving Cops3
  • Incidental Mutations
Mice homozygous for disruptions in this gene display embryonic lethality with defects in developmental patterning and failure of the inner cell mass to proliferate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008091 VEGA Gene Model | MGI Sequence Detail 22044 C57BL/6J ±  kb
transcript OTTMUST00000018389 VEGA | MGI Sequence Detail 1646 Not Applicable  
polypeptide OTTMUSP00000008453 VEGA | MGI Sequence Detail 423 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    126 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005740 COP9 signalosome complex subunit 3
  • InterPro Domains
    IPR000717 Proteasome component (PCI) domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 177
    cDNA 177

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Diseases 3
    Gene Ontology 4
    Phenotypes 20
  • Earliest
    J:50270 Wei N, et al., The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Curr Biol. 1998 Jul 30-Aug 13;8(16):919-22
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory