B3galnt1
Gene Detail

Symbol Name ID

B3galnt1 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 MGI:1349405

Synonyms

B3galt3, Brainiac 1, Globoside blood group, Mbrn 1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

32.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:69574186-69598861 bp, - strand From NCBI annotation of GRCm38   24676 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human B3galnt1 ± 2 cM)

Gene Tree: B3galnt1

Human ortholog

B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) NCBI Gene ID 8706
Human Synonyms: B3GALT3, beta3Gal-T3, galT3, Gb4Cer, GLCT3, GLOB, P, P1
Human Chr3:160801671-160823160 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human B3GALNT1 (1)

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)
 

A homozygous null mutation of this gene results in embryonic lethality. Mice homozygous for a second allele appear normal.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	oligosaccharide biosynthetic process, protein glycosylation
Component	Golgi apparatus, integral to membrane, ...
Function	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity, galactosyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (204)    Tissues (140)    Images (32)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	166
RT-PCR	38

cDNA source data(30)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) cDNA(30) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000043300 (Evidence)
Entrez Gene	26879 (Evidence)
UniGene	153710
DFCI	TC1580894
DoTS	DT.40180969
NIA Mouse Gene Index	U024144
EC	2.4.1.79
Consensus CDS Project	CCDS17406.1
International Mouse Knockout Project Status	B3galnt1

Sequences

Length	Strain/Species
genomic	26879	NCBI Gene Model | MGI Sequence Detail	24676	C57BL/6J
transcript	NM_020026	RefSeq | MGI Sequence Detail	1901	NOD
polypeptide	Q920V1	UniProt | EBI | MGI Sequence Detail	331	Not Applicable

All sequences(16) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(80 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002659	Glycosyl transferase, family 31
Protein Ontology	PR:000004581	UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

Graphical View of Protein Domain Structure

References

(Earliest) J:45045 Hennet T, et al., Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. J Biol Chem. 1998 Jan 2;273(1):58-65
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(34)