Casp8ap2 MGI Mouse Gene Detail - MGI:1349399 - caspase 8 associated protein 2

Symbol

Casp8ap2
Name

caspase 8 associated protein 2
Synonyms

D4Ertd659e, FLASH, mKIAA1315

Feature Type

protein coding gene
IDs

MGI:1349399
NCBI Gene: 26885
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:32615462-32653271 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 14.27 cM
Mapping Data

4 experiments

SNPs within 2kb

778 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1349399	protein coding gene	Chr4:32615451-32653271 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028111	protein coding gene	Chr4:30077040-30122103 (+)
A/J	MGP_AJ_G0028069	protein coding gene	Chr4:29020709-29058396 (+)
AKR/J	MGP_AKRJ_G0028033	protein coding gene	Chr4:29771535-29809181 (+)
BALB/cJ	MGP_BALBcJ_G0028080	protein coding gene	Chr4:29270916-29311014 (+)
C3H/HeJ	MGP_C3HHeJ_G0027810	protein coding gene	Chr4:30056402-30095349 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028522	protein coding gene	Chr4:31261132-31300325 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025864	protein coding gene	Chr4:27078867-27117862 (+)
CAST/EiJ	MGP_CASTEiJ_G0027264	protein coding gene	Chr4:29829015-29869136 (+)
CBA/J	MGP_CBAJ_G0027782	protein coding gene	Chr4:32256655-32294720 (+)
DBA/2J	MGP_DBA2J_G0027926	protein coding gene	Chr4:29024457-29064179 (+)
FVB/NJ	MGP_FVBNJ_G0027891	protein coding gene	Chr4:28445757-28485348 (+)
LP/J	MGP_LPJ_G0028034	protein coding gene	Chr4:30172458-30210150 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027924	protein coding gene	Chr4:34868787-34908455 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028581	protein coding gene	Chr4:29760636-29802183 (+)
PWK/PhJ	MGP_PWKPhJ_G0026984	protein coding gene	Chr4:28988099-29027831 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026812	protein coding gene	Chr4:29651375-29691250 (+)
WSB/EiJ	MGP_WSBEiJ_G0027341	protein coding gene	Chr4:29785153-29823931 (+)

Human Ortholog

CASP8AP2, caspase 8 associated protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP8AP2, caspase 8 associated protein 2
Synonyms

CED-4, FLASH, RIP25
Links

HGNC:1510

NCBI Gene ID: 9994

UniProt: Q9UKL3
Chr Location

6q15; chr6:89829880-89874436 (+) GRCh38

MGI Vertebrate Homology

Casp8ap2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CASP8AP2
Gene Tree

Casp8ap2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Chemically and radiation induced

1
Gene trapped

22
Targeted

1
Genomic Mutations

1 involving Casp8ap2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

76 strains or lines available

Mice homozygous for disruption of this gene die before implantation.

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All GO Annotations

43
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

854
Tissues

13
cDNA Data

111
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase casp8ap2

ZFIN casp8ap2

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All Sequences

59
RefSeq

8
UniProt

5
CCDS

CCDS18016.1

Ensembl

ENSMUSG00000028282 (Evidence)
NCBI Gene

26885

			Length	Strain/Species	Flank
genomic	26885	NCBI Gene Model \| MGI Sequence Detail	37810	C57BL/6J	± kb
transcript	NM_011997	RefSeq \| MGI Sequence Detail	6813	ZRU/MplStud
polypeptide	Q9WUF3	UniProt \| EBI \| MGI Sequence Detail	1962	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005055 CASP8-associated protein 2

(term hierarchy)
InterPro Domains

IPR039674 CASP8-associated protein 2

IPR049257 Gon4l/CASP8AP2, myb-like domain

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All nucleic 112

cDNA 111

Primer pair 1

Microarray probesets 4

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MGI:1277118, MGI:3034772

Summaries

All 53

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 10
Earliest

J:55798 Imai Y, et al., The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis [see comments] [published erratum appears in Nature 1999 Jul 1;400(6739):89]. Nature. 1999 Apr 29;398(6730):777-85
Latest

J:294650 Hemker SL, et al., Deletion of hypoxia-responsive microRNA-210 results in a sex-specific decrease in nephron number. FASEB J. 2020 Apr;34(4):5782-5799

TSS for Casp8ap2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36707	Chr4:32615428-32615468 (+)	-14 bp
Tssr36708	Chr4:32615477-32615487 (+)	20 bp
Tssr36709	Chr4:32615489-32615505 (+)	35 bp
Tssr36710	Chr4:32623985-32623989 (+)	8,525 bp
Tssr36711	Chr4:32626872-32626891 (+)	11,420 bp
Tssr1131	Chr4:32652768-32652785 (+)	37,315 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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